Detailed information NTG0318981

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: D5S13_RS10425
• Genome accession: NZ_CP032821
• Coordinates: 2107162..2108205 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JDFM SA01
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2102162..2113205

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D5S13_RS10395	-	2102576..2102687 (+)	112	Protein_2035	hypothetical protein	-
D5S13_RS10400 (D5S13_01984)	-	2102716..2103081 (+)	366	WP_411567597.1	hypothetical protein	-
D5S13_RS10405 (D5S13_01985)	-	2103512..2104498 (-)	987	WP_000999713.1	FUSC family protein	-
D5S13_RS10410 (D5S13_01986)	map	2105088..2105846 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
D5S13_RS10415 (D5S13_01987)	-	2106063..2106449 (+)	387	WP_001110179.1	hypothetical protein	-
D5S13_RS10420 (D5S13_01988)	liaF	2106464..2107165 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
D5S13_RS10425 (D5S13_01989)	vraS	2107162..2108205 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
D5S13_RS10430 (D5S13_01990)	vraR	2108195..2108824 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
D5S13_RS10435 (D5S13_01991)	-	2108936..2110153 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
D5S13_RS10440 (D5S13_01992)	-	2110431..2110706 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
D5S13_RS10445 (D5S13_01993)	-	2110713..2111177 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
D5S13_RS10450 (D5S13_01994)	-	2111324..2111524 (+)	201	WP_000180460.1	DUF1128 family protein	-
D5S13_RS10455 (D5S13_01995)	-	2111527..2112783 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=318981 D5S13_RS10425 WP_001017131.1 2107162..2108205(+) (vraS) [Staphylococcus aureus strain JDFM SA01]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=318981 D5S13_RS10425 WP_001017131.1 2107162..2108205(+) (vraS) [Staphylococcus aureus strain JDFM SA01]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1