Detailed information NTG0318276

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: D8S76_RS06500
• Genome accession: NZ_CP032699
• Coordinates: 1269365..1270402 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain TSPY155
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1264365..1275402

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D8S76_RS06480 (D8S76_06480)	-	1265115..1265741 (+)	627	WP_023079342.1	A24 family peptidase	-
D8S76_RS06485 (D8S76_06485)	rlmN	1265823..1266902 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
D8S76_RS06490 (D8S76_06490)	-	1266906..1267526 (-)	621	WP_161737269.1	YutD family protein	-
D8S76_RS06495 (D8S76_06495)	-	1267974..1268951 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
D8S76_RS06500 (D8S76_06500)	sepM	1269365..1270402 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
D8S76_RS06505 (D8S76_06505)	coaD	1270389..1270880 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
D8S76_RS06510 (D8S76_06510)	rsmD	1270870..1271409 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
D8S76_RS06515 (D8S76_06515)	asnA	1271532..1272524 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
D8S76_RS06520 (D8S76_06520)	arcC	1272837..1273787 (-)	951	WP_010922501.1	carbamate kinase	-
D8S76_RS06525 (D8S76_06525)	-	1273807..1275138 (-)	1332	WP_115224608.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=318276 D8S76_RS06500 WP_010922499.1 1269365..1270402(-) (sepM) [Streptococcus pyogenes strain TSPY155]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=318276 D8S76_RS06500 WP_010922499.1 1269365..1270402(-) (sepM) [Streptococcus pyogenes strain TSPY155]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693