Detailed information NTG0317068

Bioinformatically predicted

Overview

• Name: hexB
• Type: Machinery gene
• Locus tag: E1950_RS06205
• Genome accession: NZ_CP039162
• Coordinates: 1228067..1230076 (+)
• Length: 669 a.a.
• NCBI ID: WP_000516269.1
• Uniprot ID: B1VK93
• Organism: Staphylococcus aureus strain Lr12
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1223067..1235076

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E1950_RS06190 (E1950_06310)	-	1224250..1224615 (+)	366	WP_000282386.1	RicAFT regulatory complex protein RicA family protein	-
E1950_RS06195 (E1950_06315)	thiW	1224642..1225133 (+)	492	WP_000842277.1	energy coupling factor transporter S component ThiW	-
E1950_RS06200 (E1950_06320)	hexA	1225436..1228054 (+)	2619	WP_000073352.1	DNA mismatch repair protein MutS	Machinery gene
E1950_RS06205 (E1950_06325)	hexB	1228067..1230076 (+)	2010	WP_000516269.1	DNA mismatch repair endonuclease MutL	Machinery gene
E1950_RS06210 (E1950_06330)	-	1230082..1230624 (+)	543	WP_001077635.1	glycerol-3-phosphate responsive antiterminator	-
E1950_RS06215 (E1950_06335)	-	1231099..1231917 (+)	819	WP_001103743.1	MIP/aquaporin family protein	-
E1950_RS06220 (E1950_06340)	glpK	1232046..1233542 (+)	1497	WP_000417372.1	glycerol kinase GlpK	-

Sequence

Protein

• Length: 669 a.a.
• Molecular weight: 76871.06 Da
• Isoelectric Point: 5.0107

>NTDB_id=317068 E1950_RS06205 WP_000516269.1 1228067..1230076(+) (hexB) [Staphylococcus aureus strain Lr12]
MGKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNGSGIEAEDLGLVFHRHATSK
LDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGNEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYI
KSLYTELGKITDIVNRMAMSHPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPE
HSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHPTKLEVRLSKEEQLYQLIVSK
IQEAFKDRILIPKNNLDYVPKKNKVLYSFEQQKIEFEQRQNTENNQEKTFSSEESNSKSFMAENQNDEIVIKEDSYNPFV
TKTSESLITDDESSGYNNTREKDEDYFKKQQEILQEMDQTFDSNEDASVQNYENKASDDYYDVNDIKGTKSKDPKRRIPY
MEIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFSKDEQLVIDQYKNELQQVGIM
LEHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKVDIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREA
EDPFTCPHGRPIIINFSKYELEKLFKRVM

Nucleotide

• Length: 2010 bp

>NTDB_id=317068 E1950_RS06205 WP_000516269.1 1228067..1230076(+) (hexB) [Staphylococcus aureus strain Lr12]
ATGGGGAAAATTAAAGAACTCCAAACCTCATTAGCAAATAAAATCGCAGCAGGTGAAGTAGTTGAAAGACCGAGTTCTGT
TGTGAAAGAACTGTTGGAAAATGCTATAGATGCAGGCGCTACAGAAATAAGCATTGAAGTAGAGGAATCTGGCGTCCAAT
CTATTCGCGTAGTCGATAATGGAAGCGGAATTGAAGCGGAAGACTTAGGATTAGTATTTCATAGACATGCGACTAGTAAA
TTAGATCAAGATGAAGATTTATTTCATATTAGGACATTAGGATTCCGTGGTGAAGCACTAGCCAGTATTTCATCAGTTGC
TAAAGTAACATTGAAGACTTGCACGGATAATGCTAATGGAAATGAAATATATGTAGAAAATGGTGAAATATTAAATCATA
AGCCTGCAAAAGCGAAAAAAGGAACAGATATACTTGTAGAATCATTATTTTATAATACACCAGCACGTTTAAAATATATT
AAAAGTTTATACACTGAACTAGGTAAAATAACAGATATTGTCAATAGAATGGCTATGAGCCATCCGGACATTCGAATAGC
ACTCATTTCAGATGGCAAAACAATGTTAAGTACAAATGGTTCAGGACGAACTAATGAAGTGATGGCAGAGATTTATGGGA
TGAAAGTTGCACGAGATTTAGTACATATATCTGGAGATACAAGTGATTATCACATTGAAGGTTTTGTTGCAAAGCCTGAA
CATTCTAGAAGTAATAAGCACTATATTTCTATTTTTATTAATGGACGATACATTAAAAACTTTATGCTAAATAAAGCGAT
TTTAGAAGGCTATCATACACTCTTAACAATAGGTAGGTTCCCGATTTGTTATATTAATATTGAAATGGATCCAATCTTAG
TAGACGTAAATGTTCATCCAACAAAACTAGAAGTGCGTTTATCAAAAGAAGAGCAACTATATCAATTGATAGTGAGCAAA
ATACAAGAAGCATTTAAAGACCGTATATTAATTCCTAAAAATAACTTGGATTATGTGCCAAAAAAAAATAAAGTATTATA
TTCATTCGAACAACAAAAAATCGAATTTGAACAAAGACAAAACACAGAGAATAACCAAGAGAAGACGTTTTCATCTGAAG
AAAGTAACAGTAAGTCATTTATGGCAGAAAATCAAAACGATGAGATAGTTATAAAAGAAGATTCATATAATCCATTCGTA
ACGAAAACATCTGAAAGTTTAATAACTGATGATGAATCTTCTGGTTATAATAATACACGTGAAAAAGATGAAGACTACTT
CAAAAAACAACAAGAAATTTTACAAGAAATGGATCAAACATTTGATTCAAATGAGGATGCATCTGTGCAAAATTATGAGA
ATAAAGCGTCTGATGATTATTATGATGTAAACGATATTAAAGGAACAAAAAGTAAAGACCCTAAACGAAGAATTCCATAT
ATGGAAATTGTTGGCCAAGTACATGGGACGTATATTATTGCTCAAAATGAATTTGGCATGTACATGATTGACCAGCATGC
AGCTCAAGAAAGAATAAAATATGAATATTTTCGAGATAAAATAGGTGAAGTTACCAATGAAGTACAAGATTTATTAATCC
CGTTAACATTTCATTTTTCAAAGGATGAACAATTAGTTATTGATCAATATAAAAATGAGCTTCAACAAGTAGGTATCATG
TTAGAACATTTTGGTGGTCATGATTATATTGTAAGTAGCTATCCAGTTTGGTTCCCTAAAGATGAAGTAGAAGAAATCAT
TAAAGATATGATTGAGCTAATTTTGGAAGAGAAAAAAGTAGATATTAAAAAATTACGTGAAGATGTAGCAATCATGATGT
CATGTAAAAAATCTATTAAAGCGAATCATTATTTACAAAAACATGAAATGTCTGATTTAATTGATCAATTAAGAGAAGCG
GAAGATCCATTTACATGTCCACATGGTCGTCCAATAATCATTAATTTTTCAAAATACGAATTAGAAAAATTATTTAAGCG
TGTGATGTAG

Domains

Predicted by InterProScan.

• MutL C terminal dimerisation domain (MutL_C) (483-625)

• DNA mismatch repair protein, C-terminal domain (DNA_mis_repair) (209-325)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3) (25-118)

3D structure

• AlphaFold DB: B1VK93

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexB	Streptococcus pneumoniae R6	40.828	100	0.413