Detailed information NTG0316929

Bioinformatically predicted

Overview

• Name: irvR
• Type: Regulator
• Locus tag: E5491_RS11325
• Genome accession: NZ_CP039156
• Coordinates: 2158798..2159505 (+)
• Length: 235 a.a.
• NCBI ID: WP_000094093.1
• Uniprot ID: A0A1D4DWM6
• Organism: Staphylococcus aureus strain WCUH29
• Function: regulate expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2153798..2164505

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E5491_RS11270 (E5491_11325)	-	2154693..2154956 (-)	264	WP_001205732.1	hypothetical protein	-
E5491_RS11275 (E5491_11330)	-	2154965..2155225 (-)	261	WP_000291506.1	DUF1108 family protein	-
E5491_RS11280 (E5491_11335)	-	2155230..2155533 (-)	304	Protein_2126	DUF2482 family protein	-
E5491_RS11285 (E5491_11340)	-	2155627..2155788 (-)	162	WP_031766022.1	DUF1270 domain-containing protein	-
E5491_RS11290 (E5491_11345)	-	2155785..2156105 (-)	321	WP_001120197.1	DUF771 domain-containing protein	-
E5491_RS11295 (E5491_11350)	-	2156160..2156540 (+)	381	WP_000762521.1	DUF2513 domain-containing protein	-
E5491_RS11300 (E5491_11355)	-	2156527..2156724 (-)	198	WP_001148862.1	hypothetical protein	-
E5491_RS11305 (E5491_11360)	-	2156740..2157495 (-)	756	WP_001148343.1	phage antirepressor KilAC domain-containing protein	-
E5491_RS11310 (E5491_11365)	-	2157552..2158091 (+)	540	WP_000351243.1	hypothetical protein	-
E5491_RS11315 (E5491_11370)	-	2158115..2158375 (-)	261	WP_000435341.1	transcriptional regulator	-
E5491_RS11320 (E5491_11375)	-	2158388..2158627 (-)	240	WP_000548576.1	helix-turn-helix transcriptional regulator	-
E5491_RS11325 (E5491_11380)	irvR	2158798..2159505 (+)	708	WP_000094093.1	XRE family transcriptional regulator	Regulator
E5491_RS15260	-	2159517..2159663 (+)	147	WP_001049401.1	hypothetical protein	-
E5491_RS11330 (E5491_11385)	-	2159660..2159845 (+)	186	WP_000100503.1	hypothetical protein	-
E5491_RS11335 (E5491_11390)	-	2160045..2160212 (+)	168	WP_031806878.1	hypothetical protein	-
E5491_RS11340 (E5491_11395)	-	2160510..2161583 (+)	1074	WP_031929590.1	Abi family protein	-
E5491_RS11345 (E5491_11400)	-	2161644..2162681 (+)	1038	WP_000857188.1	site-specific integrase	-
E5491_RS11350 (E5491_11405)	sph	2162732..2163562 (+)	831	Protein_2141	sphingomyelin phosphodiesterase	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 26769.35 Da
• Isoelectric Point: 5.4082

>NTDB_id=316929 E5491_RS11325 WP_000094093.1 2158798..2159505(+) (irvR) [Staphylococcus aureus strain WCUH29]
MSSFSSNLERLMNKRDMSDSELAELVDVNRTTVTRWRKGIRSPKLDKLPEIANVFGVKPLDLIHDMDDSKIIEEIHNVSS
QLTPPRQSNVLKYATNQLEEQNNDSDNLVDFNSYIQEKSEVDIYGCASAGIGERLYNEPISKEFVRGYVPAHDIALKVNG
DSMEPLFKNGQIIFIEKSHTIKDGQIGVFIINGDAYVKKVYVEDNRLTLVSLNKKYKDLHFYDNESVRLVGKVIL

Nucleotide

• Length: 708 bp

>NTDB_id=316929 E5491_RS11325 WP_000094093.1 2158798..2159505(+) (irvR) [Staphylococcus aureus strain WCUH29]
ATGAGTTCATTTTCTTCGAATCTAGAACGTCTGATGAACAAAAGAGATATGAGTGATAGTGAATTAGCAGAATTAGTAGA
TGTAAATAGAACAACAGTCACAAGATGGAGAAAGGGAATTAGAAGTCCAAAACTAGATAAATTACCTGAAATAGCTAATG
TTTTTGGAGTTAAACCCTTAGATTTAATACATGATATGGATGATTCGAAAATTATTGAAGAAATTCATAACGTGTCATCT
CAACTCACGCCTCCAAGACAAAGCAATGTACTAAAATATGCGACTAATCAATTAGAAGAGCAAAATAATGACAGTGATAA
TCTGGTAGATTTCAATTCTTACATTCAAGAAAAATCCGAAGTGGATATATATGGTTGTGCGTCTGCTGGTATTGGTGAAA
GATTATATAACGAGCCTATTTCAAAAGAATTCGTAAGAGGTTATGTCCCCGCACATGATATAGCTTTAAAAGTAAATGGA
GACTCAATGGAGCCGTTATTTAAAAATGGACAAATTATATTCATTGAAAAATCTCACACTATCAAAGATGGACAAATAGG
CGTCTTTATTATAAATGGAGATGCTTACGTAAAGAAGGTTTATGTAGAAGATAACAGATTAACGTTGGTTTCTTTAAATA
AAAAGTATAAAGATTTACATTTTTATGATAATGAAAGTGTGAGGTTAGTTGGAAAAGTTATTTTATAG

Domains

Predicted by InterProScan.

• Peptidase S24-like (Peptidase_S24) (123-234)

• Helix-turn-helix (HTH_3) (8-61)

3D structure

• AlphaFold DB: A0A1D4DWM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
irvR	Streptococcus mutans UA159	30.769	100	0.374