Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   D6869_RS04630 Genome accession   NZ_CP032526
Coordinates   875100..875792 (+) Length   230 a.a.
NCBI ID   WP_011834861.1    Uniprot ID   Q9K570
Organism   Lactococcus cremoris strain 4B0     
Function   repress the expression of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 870100..880792
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D6869_RS04600 (D6869_04660) arsC 870757..871161 (+) 405 WP_011676637.1 arsenate reductase (thioredoxin) -
  D6869_RS04605 (D6869_04665) - 871273..872109 (+) 837 WP_011834858.1 metallophosphoesterase -
  D6869_RS04610 (D6869_04670) - 872202..873113 (+) 912 WP_011676635.1 CHAP domain-containing protein -
  D6869_RS04615 (D6869_04675) - 873350..873712 (+) 363 WP_011834859.1 TIGR02328 family protein -
  D6869_RS04620 (D6869_04680) - 874036..874281 (+) 246 WP_011676633.1 type B 50S ribosomal protein L31 -
  D6869_RS04625 (D6869_04685) - 874414..874944 (+) 531 WP_011834860.1 DUF177 domain-containing protein -
  D6869_RS04630 (D6869_04690) covR 875100..875792 (+) 693 WP_011834861.1 response regulator transcription factor Regulator
  D6869_RS04635 (D6869_04695) covS 875797..877269 (+) 1473 WP_041931273.1 HAMP domain-containing histidine kinase Regulator
  D6869_RS04640 (D6869_04700) - 877455..878696 (+) 1242 WP_014734987.1 ammonium transporter -
  D6869_RS04645 (D6869_04705) - 878778..879119 (+) 342 WP_011676628.1 P-II family nitrogen regulator -
  D6869_RS04650 (D6869_04710) murD 879288..880637 (+) 1350 WP_011834864.1 UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase -

Sequence

Protein


Download         Length: 230 a.a.        Molecular weight: 26654.33 Da        Isoelectric Point: 5.1273

>NTDB_id=316712 D6869_RS04630 WP_011834861.1 875100..875792(+) (covR) [Lactococcus cremoris strain 4B0]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGIEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide


Download         Length: 693 bp        

>NTDB_id=316712 D6869_RS04630 WP_011834861.1 875100..875792(+) (covR) [Lactococcus cremoris strain 4B0]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGATTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(6-115)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-226)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9K570

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Lactococcus lactis subsp. lactis strain DGCC12653

99.13

100

0.991
  covR Streptococcus salivarius strain HSISS4

67.982

99.13

0.674
  vicR Streptococcus mutans UA159

45.455

100

0.457
  micA Streptococcus pneumoniae Cp1015

43.043

100

0.43
  ciaR Streptococcus mutans UA159

37.168

98.261

0.365

Multiple sequence alignment