Detailed information NTG0316708

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: D6869_RS03205
• Genome accession: NZ_CP032526
• Coordinates: 603685..606135 (+)
• Length: 816 a.a.
• NCBI ID: WP_011834628.1
• Uniprot ID: -
• Organism: Lactococcus cremoris strain 4B0
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	582290..614555	603685..606135	within	0
IScluster/Tn	600414..603009	603685..606135	flank	676

Gene organization within MGE regions

Location: 582290..614555

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D6869_RS03075 (D6869_03105)	-	582290..582958 (+)	669	WP_011834609.1	hypothetical protein	-
D6869_RS03080 (D6869_03110)	-	583123..584025 (+)	903	WP_011675768.1	SPFH domain-containing protein	-
D6869_RS03090 (D6869_03120)	-	584274..585290 (-)	1017	WP_011834610.1	site-specific integrase	-
D6869_RS03095 (D6869_03125)	-	585511..586002 (-)	492	WP_011834611.1	hypothetical protein	-
D6869_RS03100 (D6869_03130)	-	586058..586263 (-)	206	Protein_588	hypothetical protein	-
D6869_RS03105 (D6869_03135)	-	586278..586487 (-)	210	WP_011834612.1	hypothetical protein	-
D6869_RS03110 (D6869_03140)	-	586555..586806 (-)	252	WP_011834613.1	hypothetical protein	-
D6869_RS03115	-	586772..587062 (-)	291	WP_162467000.1	hypothetical protein	-
D6869_RS03120	-	587043..587219 (-)	177	WP_014734944.1	hypothetical protein	-
D6869_RS03125 (D6869_03150)	-	587513..589120 (+)	1608	WP_011834615.1	glycosyltransferase family 39 protein	-
D6869_RS03130 (D6869_03155)	-	589044..589976 (+)	933	WP_161769936.1	glycosyltransferase family 2 protein	-
D6869_RS03135 (D6869_03160)	-	590243..590734 (-)	492	WP_011834617.1	hypothetical protein	-
D6869_RS03140 (D6869_03165)	-	590747..591121 (-)	375	WP_011834618.1	PH domain-containing protein	-
D6869_RS03145 (D6869_03170)	-	591466..591813 (-)	348	WP_011834619.1	XRE family transcriptional regulator	-
D6869_RS03155 (D6869_03180)	rnz	592579..593502 (+)	924	WP_011834620.1	ribonuclease Z	-
D6869_RS03160 (D6869_03185)	-	593495..594196 (+)	702	WP_014734945.1	SDR family NAD(P)-dependent oxidoreductase	-
D6869_RS03165 (D6869_03190)	recJ	594369..596597 (+)	2229	WP_014734946.1	single-stranded-DNA-specific exonuclease RecJ	-
D6869_RS03170 (D6869_03195)	-	596721..597233 (+)	513	WP_011834623.1	adenine phosphoribosyltransferase	-
D6869_RS03175 (D6869_03200)	rpoE	597449..598015 (+)	567	WP_011834624.1	DNA-directed RNA polymerase subunit delta	-
D6869_RS03180 (D6869_03205)	mltG	598151..599791 (+)	1641	WP_041931175.1	endolytic transglycosylase MltG	-
D6869_RS03185 (D6869_03210)	greA	599852..600322 (+)	471	WP_011834626.1	transcription elongation factor GreA	-
D6869_RS03190 (D6869_03220)	-	600414..601790 (+)	1377	Protein_605	IS3-like element ISLla3 family transposase	-
D6869_RS03195 (D6869_03225)	-	601862..603009 (+)	1148	WP_101928132.1	IS3 family transposase	-
D6869_RS03200 (D6869_03230)	-	603240..603695 (+)	456	WP_011834627.1	CtsR family transcriptional regulator	-
D6869_RS03205 (D6869_03235)	clpC	603685..606135 (+)	2451	WP_011834628.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
D6869_RS03210 (D6869_03240)	raiA	606270..606827 (+)	558	WP_011834629.1	ribosome-associated translation inhibitor RaiA	-
D6869_RS03215 (D6869_03245)	eno	607015..608316 (+)	1302	WP_010905473.1	surface-displayed alpha-enolase	-
D6869_RS03220 (D6869_03250)	-	608405..609340 (+)	936	WP_011834630.1	tyrosine-type recombinase/integrase	-
D6869_RS03225 (D6869_03255)	-	609467..610099 (+)	633	WP_011834631.1	hypothetical protein	-
D6869_RS03230 (D6869_03260)	-	610096..611253 (-)	1158	Protein_613	IS3-like element IS-LL6 family transposase	-
D6869_RS03240 (D6869_03270)	-	612670..613350 (+)	681	WP_011834633.1	putative phage abortive infection protein	-
D6869_RS03245 (D6869_03275)	-	613685..613780 (+)	96	WP_010905490.1	hypothetical protein	-
D6869_RS03250 (D6869_03280)	-	613884..614555 (-)	672	WP_011834634.1	ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 816 a.a.
• Molecular weight: 90362.78 Da
• Isoelectric Point: 6.6284

>NTDB_id=316708 D6869_RS03205 WP_011834628.1 603685..606135(+) (clpC) [Lactococcus cremoris strain 4B0]
MKFENVKYTPTLDRIFEKAAEYAHQYQYGTIESAHLLAAMATTSGSIAYSILAGMNVDSSDLLIDLEDLSSHVKVKRSEL
RFSPRAEEVVTVASFLAVHNNAEAVGTEHLLYALLQVEDGFGLQLLKLQKINIVSLRKEIEKRTGLKVPENKKAVTPMSK
RKMAKGVAENSSTPTLDSVSSDLTEAARSGKLDPMIGREAEVDRLIHILSRRTKNNPVLVGEPGVGKSAIIEGLAQRIVN
GQVPIGLMNSRIMALNMATVVAGTKFRGEFEDRLTAIVEEVSADPDVIIFIDELHTIIGAGGGMDSVNDAANILKPALAR
GDFQMVGATTYHEYQKYIEKDEALERRLARINVDEPSPDEAIAILQGLREKFEDYHQVKFTDQAIKSAVTLSVRYMTSRK
LPDKAIDLLDEAAAAVKISVKNQETKRLELEKDLVKAQEELAEAVIKLDVKASRIKEKAVEKISDKIYKFSIKEEKRQEV
TDQAVIAVASTLTGVPITQMTKSESDRLINLEKELHKRVVGQEEAISAVSRAIRRARSGVADSRRPMGSFMFLGPTGVGK
TELAKALADSVFGSEDNMIRVDMSEFMEKHSTSRLIGAPPGYVGYDEGGQLTERVRNKPYSVVLLDEVEKAHLDVFNIML
QILDDGFVTDTKGRKVDFRNTIIIMTSNLGATALRDDKTVGFGAKNITADYSAMQSRILEELKRHYRPEFLNRIDENIVF
HSLESQEIEQIVKIMSKSLIKRLAEQDIHVKLTPSAIKLIAEVGFDPEYGARPLRKALQKEVEDLLSEQLLSGEIKAGNH
ISIGASNKKIKIAQIV

Nucleotide

• Length: 2451 bp

>NTDB_id=316708 D6869_RS03205 WP_011834628.1 603685..606135(+) (clpC) [Lactococcus cremoris strain 4B0]
ATGAAATTTGAAAATGTAAAATATACACCAACACTGGACCGAATTTTCGAGAAAGCAGCAGAATATGCCCACCAATATCA
ATACGGTACGATTGAAAGTGCTCATTTATTGGCAGCAATGGCTACTACTTCAGGCTCAATTGCTTACAGTATTCTTGCTG
GAATGAATGTTGATTCTTCAGACTTACTGATTGATTTGGAAGATTTATCTAGCCATGTCAAAGTGAAACGTTCTGAATTA
CGTTTCTCTCCTCGCGCAGAAGAAGTGGTTACTGTAGCTAGCTTTTTGGCAGTTCATAATAATGCAGAAGCAGTAGGAAC
AGAGCATTTGCTTTATGCATTACTTCAAGTCGAAGATGGTTTTGGTCTTCAACTTTTGAAGTTACAAAAAATCAACATTG
TTTCTTTGCGAAAAGAAATTGAAAAAAGAACAGGACTTAAAGTTCCAGAAAACAAAAAAGCTGTAACACCAATGTCCAAA
CGTAAGATGGCAAAAGGGGTAGCAGAGAATTCAAGTACACCAACTTTGGATTCAGTTTCTTCAGATTTAACTGAAGCTGC
TCGTTCAGGAAAGCTTGACCCAATGATTGGTCGGGAAGCAGAAGTTGACCGTTTGATTCATATTCTTAGTCGTAGAACAA
AAAATAACCCTGTTTTAGTTGGTGAACCTGGTGTTGGTAAATCAGCAATAATCGAGGGATTGGCTCAAAGAATTGTCAAC
GGCCAAGTACCTATCGGTTTGATGAATAGCCGGATTATGGCTCTAAATATGGCAACTGTTGTTGCTGGTACAAAATTTAG
AGGTGAATTTGAAGACCGCTTGACAGCAATTGTTGAAGAAGTAAGTGCTGACCCAGATGTCATCATTTTCATTGATGAAT
TGCATACAATTATTGGTGCTGGCGGGGGCATGGACTCGGTCAATGATGCAGCAAATATTTTAAAACCAGCCCTTGCACGT
GGTGACTTTCAAATGGTTGGGGCAACGACTTATCATGAATACCAAAAATACATTGAAAAAGATGAAGCATTAGAACGTCG
TTTGGCAAGAATCAATGTTGATGAGCCAAGTCCAGATGAAGCCATTGCTATCTTACAAGGGTTACGTGAGAAATTTGAAG
ATTATCATCAAGTAAAATTTACTGACCAAGCGATTAAAAGCGCAGTGACACTTAGTGTTCGGTACATGACCAGTCGCAAA
TTGCCTGATAAAGCCATTGACTTGCTCGATGAAGCAGCGGCAGCAGTTAAAATTTCTGTTAAAAACCAAGAAACAAAACG
TCTTGAATTAGAGAAAGACTTAGTTAAAGCTCAAGAAGAACTAGCGGAAGCTGTCATTAAACTTGATGTTAAAGCCTCTC
GCATCAAAGAAAAAGCTGTTGAAAAAATTTCTGACAAGATTTATAAATTCTCAATAAAAGAGGAAAAACGTCAAGAAGTT
ACTGACCAAGCTGTTATTGCTGTTGCCTCAACGCTGACAGGTGTTCCAATTACTCAAATGACTAAATCTGAAAGCGACCG
TTTGATTAATCTTGAAAAAGAATTGCACAAACGGGTCGTTGGTCAAGAAGAAGCAATTTCTGCGGTTTCAAGAGCCATTC
GTCGGGCACGTTCTGGTGTGGCTGATAGTCGCCGTCCAATGGGTTCATTTATGTTTCTAGGACCAACTGGTGTTGGGAAA
ACTGAGTTAGCTAAGGCCTTGGCCGATAGTGTTTTTGGTAGCGAAGACAACATGATTCGAGTGGACATGAGTGAATTCAT
GGAAAAACATTCAACTTCACGCTTGATTGGGGCCCCTCCAGGATATGTTGGTTATGATGAAGGTGGTCAATTGACTGAAC
GCGTTCGTAATAAACCCTATTCTGTGGTTCTTTTAGATGAAGTTGAGAAAGCTCATCTTGACGTTTTCAATATCATGTTG
CAAATTCTAGATGATGGATTTGTGACAGATACAAAGGGCCGCAAAGTTGATTTTAGAAACACAATTATTATCATGACTTC
AAACTTGGGTGCAACGGCTCTTCGTGATGATAAAACAGTTGGTTTTGGTGCAAAAAATATCACGGCTGACTACTCAGCTA
TGCAATCAAGAATTTTGGAAGAACTTAAACGTCATTATCGTCCAGAGTTTCTCAATCGTATTGATGAAAACATTGTTTTC
CATTCATTGGAAAGTCAAGAAATTGAACAAATTGTTAAGATTATGAGCAAATCTTTGATTAAACGTTTGGCGGAACAAGA
TATTCATGTGAAACTTACGCCATCAGCAATAAAACTAATCGCTGAAGTAGGATTTGACCCAGAATATGGGGCACGTCCAT
TGCGTAAAGCACTCCAAAAAGAAGTTGAAGATCTTTTAAGTGAACAATTGCTCTCGGGTGAGATTAAAGCAGGAAATCAT
ATTTCCATTGGTGCTTCTAATAAAAAAATTAAAATCGCTCAAATTGTTTGA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (723-802)

• AAA lid domain (AAA_lid_9) (357-449)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (96-144)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (19-69)

• AAA domain (Cdc48 subfamily) (AAA_2) (545-716)

• ATPase family associated with various cellular activities (AAA) (AAA) (218-334)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	95.956	100	0.96
clpC	Streptococcus thermophilus LMD-9	50.903	100	0.518
clpC	Streptococcus thermophilus LMG 18311	50.782	100	0.517
clpC	Streptococcus pneumoniae Rx1	49.396	100	0.501
clpC	Streptococcus pneumoniae D39	49.396	100	0.501
clpC	Streptococcus pneumoniae TIGR4	49.275	100	0.5
clpC	Streptococcus mutans UA159	48.918	100	0.499
clpC	Bacillus subtilis subsp. subtilis str. 168	50.125	98.284	0.493
clpE	Streptococcus mutans UA159	46.769	79.657	0.373
clpC	Lactococcus lactis subsp. cremoris KW2	46.472	79.902	0.371
clpE	Streptococcus pneumoniae TIGR4	46.89	76.838	0.36
clpE	Streptococcus pneumoniae Rx1	46.89	76.838	0.36
clpE	Streptococcus pneumoniae D39	46.89	76.838	0.36
clpE	Streptococcus pneumoniae R6	46.89	76.838	0.36