Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   D4K70_RS03655 Genome accession   NZ_CP032476
Coordinates   721422..723206 (-) Length   594 a.a.
NCBI ID   WP_139532025.1    Uniprot ID   -
Organism   Helicobacter pylori strain 381-C-EK1     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 716422..728206
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D4K70_RS03625 - 716813..717061 (+) 249 WP_000790557.1 RNA-binding protein -
  D4K70_RS03630 - 717278..718099 (-) 822 WP_139546089.1 glycosyltransferase family 25 protein -
  D4K70_RS03635 trxB 718452..719387 (-) 936 WP_139532023.1 thioredoxin-disulfide reductase -
  D4K70_RS03640 trxA 719393..719713 (-) 321 WP_000020199.1 thioredoxin -
  D4K70_RS03645 - 719802..720146 (-) 345 WP_001211718.1 YraN family protein -
  D4K70_RS03650 - 720146..721411 (-) 1266 WP_139532024.1 homoserine dehydrogenase -
  D4K70_RS03655 uvrC 721422..723206 (-) 1785 WP_139532025.1 excinuclease ABC subunit UvrC Machinery gene
  D4K70_RS03660 - 723207..723668 (-) 462 WP_000437179.1 hypothetical protein -
  D4K70_RS03665 - 723660..723839 (+) 180 WP_000468793.1 hypothetical protein -
  D4K70_RS03670 - 723851..724492 (-) 642 WP_139532026.1 ATP-binding cassette domain-containing protein -
  D4K70_RS03675 - 724494..726155 (-) 1662 WP_139532858.1 ABC transporter permease/substrate-binding protein -
  D4K70_RS03680 - 726224..726661 (-) 438 WP_201736683.1 hypothetical protein -
  D4K70_RS03685 motB 726667..727440 (-) 774 WP_139532027.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68539.75 Da        Isoelectric Point: 9.7529

>NTDB_id=316228 D4K70_RS03655 WP_139532025.1 721422..723206(-) (uvrC) [Helicobacter pylori strain 381-C-EK1]
MADLLSSLKNLSSSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIASLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLIPEQILLN
TCSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECVPYRVEIFDT
SHHANSQCVGGMVVYENHAFQKNSYRRYHLKGSNEYAQMSELLTRRALDFAKDPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=316228 D4K70_RS03655 WP_139532025.1 721422..723206(-) (uvrC) [Helicobacter pylori strain 381-C-EK1]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTAGTAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCCATCCGTAATAATGAAATCACGCCCA
ATCATCGCGCTAGCTTACGAATCCAAATGATGGTCAAACAAATCGCTTCTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCCTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCTTTAGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAACAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTGGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGCGCAAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGATTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATACCAGAACAAATTTTATTGAAC
ACTTGCTCTAATGAAGCGCTTAAAGAATTGCAAGAATTTATCTCCCATCAATATTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTCAAATTAGAGTGCGTGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACCATGCATTCCAAAAAAACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAACGAATACGCTCAAATGAGCGAGTTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGATC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.643

100

0.976

Multiple sequence alignment