Detailed information NTG0315820

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: LLW34_RS09330
• Genome accession: NZ_CP032430
• Coordinates: 1821288..1823738 (-)
• Length: 816 a.a.
• NCBI ID: WP_205288046.1
• Uniprot ID: -
• Organism: Lactococcus cremoris strain W34
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	1802896..1838647	1821288..1823738	within	0
IScluster/Tn	1824386..1826594	1821288..1823738	flank	648

Gene organization within MGE regions

Location: 1802896..1838647

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLW34_RS09230 (LLW34_1807)	-	1803080..1803751 (+)	672	WP_014573010.1	ABC transporter ATP-binding protein	-
LLW34_RS09235 (LLW34_03240)	-	1803855..1803959 (-)	105	Protein_1805	hypothetical protein	-
LLW34_RS09240 (LLW34_1808)	-	1804240..1805622 (-)	1383	WP_363325716.1	RNA-directed DNA polymerase	-
LLW34_RS09245 (LLW34_1810)	-	1805653..1806764 (+)	1112	WP_088792927.1	IS3-like element IS981 family transposase	-
LLW34_RS09250 (LLW34_1811)	-	1806775..1807269 (-)	495	WP_205288038.1	hypothetical protein	-
LLW34_RS09255 (LLW34_1812)	-	1807892..1808632 (-)	741	WP_205288039.1	hypothetical protein	-
LLW34_RS09265 (LLW34_1815)	-	1810429..1810608 (-)	180	WP_032951429.1	hypothetical protein	-
LLW34_RS09270 (LLW34_1816)	-	1810608..1810952 (-)	345	WP_032951428.1	nucleotide pyrophosphohydrolase	-
LLW34_RS09275 (LLW34_1817)	-	1810965..1812332 (-)	1368	WP_242515007.1	DNA/RNA helicase domain-containing protein	-
LLW34_RS09280 (LLW34_1819)	-	1812572..1813729 (+)	1158	Protein_1814	IS3 family transposase	-
LLW34_RS13405 (LLW34_03245)	-	1813904..1814599 (-)	696	Protein_1815	DNA/RNA helicase domain-containing protein	-
LLW34_RS09290 (LLW34_1823)	-	1814644..1814943 (-)	300	WP_205288041.1	hypothetical protein	-
LLW34_RS09295 (LLW34_03250)	-	1814919..1815056 (-)	138	WP_205288042.1	hypothetical protein	-
LLW34_RS13355	-	1815271..1815441 (-)	171	WP_101962026.1	helix-turn-helix domain-containing protein	-
LLW34_RS09300 (LLW34_1824)	-	1815571..1816752 (-)	1182	WP_205288043.1	hypothetical protein	-
LLW34_RS09305 (LLW34_1825)	-	1816776..1816964 (-)	189	WP_042748276.1	hypothetical protein	-
LLW34_RS09310 (LLW34_1826)	-	1817023..1817259 (-)	237	WP_042748277.1	hypothetical protein	-
LLW34_RS09315 (LLW34_1827)	-	1818063..1818998 (-)	936	WP_205288044.1	tyrosine-type recombinase/integrase	-
LLW34_RS09320 (LLW34_1828)	eno	1819086..1820387 (-)	1302	WP_010905473.1	surface-displayed alpha-enolase	-
LLW34_RS09325 (LLW34_1829)	hpf	1820575..1821153 (-)	579	WP_205288045.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
LLW34_RS09330 (LLW34_1830)	clpC	1821288..1823738 (-)	2451	WP_205288046.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
LLW34_RS09335 (LLW34_1831)	-	1823728..1824183 (-)	456	WP_011834627.1	CtsR family transcriptional regulator	-
LLW34_RS13360	-	1824400..1824480 (-)	81	Protein_1827	IS3 family transposase	-
LLW34_RS09340 (LLW34_1832)	-	1824570..1825459 (+)	890	Protein_1828	IS982-like element ISLll1 family transposase	-
LLW34_RS09345 (LLW34_03255)	-	1825472..1826778 (-)	1307	Protein_1829	IS3-like element ISLla3 family transposase	-
LLW34_RS09350 (LLW34_1835)	greA	1826870..1827340 (-)	471	WP_014573028.1	transcription elongation factor GreA	-
LLW34_RS09355 (LLW34_1836)	mltG	1827401..1829041 (-)	1641	WP_021216101.1	endolytic transglycosylase MltG	-
LLW34_RS09360 (LLW34_1837)	rpoE	1829177..1829740 (-)	564	WP_021211601.1	DNA-directed RNA polymerase subunit delta	-
LLW34_RS09365 (LLW34_1838)	-	1829956..1830468 (-)	513	WP_011834623.1	adenine phosphoribosyltransferase	-
LLW34_RS09370 (LLW34_1839)	recJ	1830592..1832820 (-)	2229	WP_205288049.1	single-stranded-DNA-specific exonuclease RecJ	-
LLW34_RS09375 (LLW34_1840)	-	1832993..1833694 (-)	702	WP_205288050.1	SDR family oxidoreductase	-
LLW34_RS09380 (LLW34_1841)	rnz	1833687..1834610 (-)	924	WP_015082147.1	ribonuclease Z	-
LLW34_RS09390 (LLW34_1842)	-	1835375..1835722 (+)	348	WP_011675770.1	XRE family transcriptional regulator	-
LLW34_RS09395 (LLW34_1843)	-	1836149..1836607 (+)	459	WP_205288051.1	hypothetical protein	-
LLW34_RS09405 (LLW34_1844)	-	1837096..1837998 (-)	903	WP_011675768.1	SPFH domain-containing protein	-

Sequence

Protein

• Length: 816 a.a.
• Molecular weight: 90344.74 Da
• Isoelectric Point: 6.5290

>NTDB_id=315820 LLW34_RS09330 WP_205288046.1 1821288..1823738(-) (clpC) [Lactococcus cremoris strain W34]
MKFENVKYTPTLDRIFEKAAEDAHQYQYGTIESAHLLAAMATTSGSIAYSILAGMNVDSSDLLIDLEDLSSHVKVKRSEL
RFSPRAEEVVTVASFLAVHNNAEAVGTEHLLYALLQVEDGFCIQLLKLQKINIVSLRKEIEKRTGLKVPENKKAVTPMSK
RKMAKGVAENSSTPTLDSVSSDLTEAARSGKLDPMIGREAEVDRLIHILSRRTKNNPVLVGEPGVGKSAIIEGLAQRIVN
GQVPIGLMNSRIMALNMATVVAGTKFRGEFEDRLTAIVEEVSADPDVIIFIDELHTIIGAGGGMDSVNDAANILKPALAR
GDFQMVGATTYHEYQKYIEKDEALERRLARINVDEPSPDEAIAILQGLREKFEDYHQVKFTDQAIKSAVTLSVRYMTSRK
LPDKAIDLLDEAAAAVKISVKNQETKRLELEKDLVKAQEELAEAVIKLDVKASRIKEKAVEKISDKIYKFSIKEEKRQEV
TDQAVIAVASTLTGVPITQMTKSESDRLINLEKELHKRVVGQEEAISAVSRAIRRARSGVADSRRPMGSFMFLGPTGVGK
TELAKALADSVFGSEDNMIRVDMSEFMEKHSTSRLIGAPPGYVGYDEGGQLTERVRNKPYSVVLLDEVEKAHPDVFNIML
QILDDGFVTDTKGRKVDFRNTIIIMTSNLGATALRDDKTVGFGAKNITADYSAMQSRILEELKRHYRPEFLNRIDENIVF
HSLESQEIEQIVKIMSKSLIKRLAEQDIHVKLTPSAIKLIAEVGFDPEYGARPLRKALQKEVEDLLSEQLLSGEIKAGNH
ISIGASNKKIKIAQIV

Nucleotide

• Length: 2451 bp

>NTDB_id=315820 LLW34_RS09330 WP_205288046.1 1821288..1823738(-) (clpC) [Lactococcus cremoris strain W34]
ATGAAATTTGAAAATGTGAAATATACACCAACACTGGACCGAATTTTCGAGAAAGCAGCAGAAGATGCCCACCAATATCA
ATACGGTACGATTGAAAGTGCTCATTTATTGGCAGCAATGGCTACTACTTCAGGCTCAATTGCTTACAGTATTCTTGCTG
GAATGAATGTTGATTCTTCAGACTTACTGATTGATTTGGAAGATTTATCTAGCCATGTCAAAGTGAAACGTTCTGAATTA
CGTTTCTCTCCTCGCGCAGAAGAAGTGGTCACTGTAGCTAGCTTTTTAGCTGTTCATAATAATGCAGAAGCAGTAGGAAC
GGAGCATTTGCTTTATGCATTACTTCAAGTCGAAGATGGTTTTTGTATTCAACTTTTGAAGTTACAAAAAATCAATATTG
TTTCTTTGCGAAAAGAAATTGAAAAAAGAACAGGACTTAAAGTTCCAGAAAACAAAAAAGCTGTAACACCAATGTCCAAA
CGTAAGATGGCAAAAGGGGTAGCAGAGAATTCAAGTACACCAACTTTGGATTCAGTTTCTTCAGATTTAACTGAAGCTGC
TCGTTCAGGAAAGCTTGACCCAATGATTGGTCGGGAAGCAGAAGTTGACCGTTTGATTCATATTCTTAGTCGTAGAACAA
AAAATAACCCTGTTTTAGTTGGCGAACCTGGTGTTGGTAAATCAGCAATAATCGAGGGATTGGCTCAAAGAATTGTCAAC
GGCCAAGTACCTATCGGTTTGATGAATAGCCGGATTATGGCCCTAAATATGGCAACTGTTGTTGCTGGTACAAAATTTAG
AGGTGAATTTGAAGACCGCTTGACAGCAATTGTTGAAGAAGTAAGTGCTGACCCAGATGTCATCATTTTCATTGATGAAT
TGCATACAATTATTGGTGCTGGCGGGGGCATGGACTCGGTCAATGATGCAGCAAATATTTTAAAACCAGCCCTTGCACGT
GGTGATTTTCAAATGGTTGGGGCAACGACTTATCACGAATACCAAAAATACATTGAAAAAGATGAAGCATTAGAACGTCG
TTTGGCAAGAATCAATGTTGATGAGCCAAGTCCAGATGAAGCCATTGCTATCCTACAAGGGTTACGTGAGAAATTTGAAG
ATTATCATCAAGTAAAATTTACTGACCAAGCGATTAAAAGCGCTGTGACACTTAGTGTTCGGTACATGACCAGTCGCAAA
TTGCCTGATAAAGCCATCGACTTGCTTGATGAAGCAGCGGCAGCAGTTAAAATTTCTGTTAAAAACCAAGAAACAAAACG
TCTTGAATTAGAGAAAGACTTAGTTAAAGCTCAAGAAGAACTAGCGGAAGCTGTCATTAAACTTGATGTTAAAGCCTCTC
GCATCAAAGAAAAAGCTGTTGAAAAAATTTCTGACAAGATTTATAAATTCTCAATAAAAGAGGAAAAACGTCAAGAAGTT
ACTGACCAAGCTGTTATTGCTGTTGCCTCAACGCTGACAGGTGTTCCAATTACTCAAATGACTAAATCTGAAAGCGACCG
TTTGATTAATCTTGAAAAAGAATTGCACAAACGGGTCGTTGGTCAAGAAGAAGCAATTTCTGCGGTTTCAAGAGCCATTC
GTCGGGCACGTTCTGGTGTGGCTGATAGTCGCCGTCCAATGGGTTCATTTATGTTTCTTGGACCAACTGGTGTTGGGAAA
ACTGAGTTAGCTAAGGCCTTGGCCGATAGTGTTTTTGGTAGCGAAGACAACATGATTCGAGTGGATATGAGTGAATTTAT
GGAAAAACATTCAACTTCACGATTGATTGGAGCACCTCCAGGATATGTTGGTTATGATGAAGGTGGTCAATTGACTGAAC
GTGTTCGTAATAAACCCTATTCTGTGGTTCTTTTAGATGAAGTTGAGAAAGCTCATCCTGACGTTTTCAATATCATGTTG
CAAATTCTAGATGATGGATTTGTGACAGATACAAAGGGTCGCAAAGTTGATTTTAGAAACACAATTATTATCATGACTTC
AAACTTGGGTGCAACGGCTCTTCGTGATGATAAAACAGTTGGTTTTGGTGCAAAAAATATCACGGCTGACTACTCAGCTA
TGCAATCAAGAATTTTGGAAGAACTTAAACGTCATTATCGTCCAGAGTTTCTCAATCGTATTGATGAAAACATTGTTTTC
CATTCATTGGAAAGTCAAGAAATTGAACAAATTGTTAAGATTATGAGCAAATCTTTGATTAAACGTTTGGCGGAACAAGA
TATTCATGTGAAACTTACGCCATCAGCAATAAAACTAATCGCTGAAGTAGGATTTGACCCAGAATATGGGGCACGTCCAT
TGCGTAAAGCACTCCAAAAAGAAGTTGAAGATCTTTTAAGTGAGCAATTGCTCTCGGGTGAGATTAAAGCAGGAAATCAT
ATTTCCATTGGTGCTTCTAATAAAAAAATTAAAATCGCTCAAATTGTTTGA

Domains

Predicted by InterproScan.

• Clp amino terminal domain, pathogenicity island component (Clp_N) (96-144)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (23-69)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (723-802)

• ATPase family associated with various cellular activities (AAA) (AAA) (218-334)

• AAA domain (Cdc48 subfamily) (AAA_2) (545-716)

• AAA lid domain (AAA_lid_9) (357-449)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	95.711	100	0.957
clpC	Streptococcus thermophilus LMD-9	51.023	100	0.52
clpC	Streptococcus thermophilus LMG 18311	50.903	100	0.518
clpC	Streptococcus pneumoniae Rx1	49.517	100	0.502
clpC	Streptococcus pneumoniae D39	49.517	100	0.502
clpC	Streptococcus pneumoniae TIGR4	49.396	100	0.501
clpC	Streptococcus mutans UA159	49.038	100	0.5
clpC	Bacillus subtilis subsp. subtilis str. 168	50.249	98.284	0.494
clpE	Streptococcus mutans UA159	46.923	79.657	0.374
clpC	Lactococcus lactis subsp. cremoris KW2	46.626	79.902	0.373
clpE	Streptococcus pneumoniae TIGR4	47.049	76.838	0.362
clpE	Streptococcus pneumoniae Rx1	47.049	76.838	0.362
clpE	Streptococcus pneumoniae D39	47.049	76.838	0.362
clpE	Streptococcus pneumoniae R6	47.049	76.838	0.362