Detailed information NTG0312425

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: D1E88_RS09585
• Genome accession: NZ_CP031886
• Coordinates: 1919049..1920092 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CFSAN082783
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1914049..1925092

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D1E88_RS09555 (D1E88_09750)	-	1914470..1915717 (-)	1248	WP_000656302.1	aminopeptidase	-
D1E88_RS09560 (D1E88_09755)	-	1915729..1915929 (-)	201	WP_000180459.1	DUF1128 family protein	-
D1E88_RS09565 (D1E88_09760)	-	1916076..1916540 (+)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
D1E88_RS09570 (D1E88_09765)	-	1916547..1916822 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
D1E88_RS09575 (D1E88_09770)	-	1917100..1918317 (+)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
D1E88_RS09580 (D1E88_09775)	vraR	1918430..1919059 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
D1E88_RS09585 (D1E88_09780)	vraS	1919049..1920092 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
D1E88_RS09590 (D1E88_09785)	liaF	1920089..1920790 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
D1E88_RS09595 (D1E88_09790)	-	1920805..1921191 (-)	387	WP_001110184.1	hypothetical protein	-
D1E88_RS09600 (D1E88_09795)	map	1921408..1922166 (-)	759	WP_000636137.1	type I methionyl aminopeptidase	-
D1E88_RS09605 (D1E88_09805)	-	1922753..1923734 (+)	982	Protein_1827	FUSC family protein	-
D1E88_RS09610 (D1E88_09810)	-	1923912..1924325 (-)	414	WP_001622129.1	hypothetical protein	-
D1E88_RS09615 (D1E88_09815)	-	1924354..1924463 (-)	110	Protein_1829	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=312425 D1E88_RS09585 WP_001017131.1 1919049..1920092(-) (vraS) [Staphylococcus aureus strain CFSAN082783]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=312425 D1E88_RS09585 WP_001017131.1 1919049..1920092(-) (vraS) [Staphylococcus aureus strain CFSAN082783]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1