Detailed information NTG0311193

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: D1F65_RS10140
• Genome accession: NZ_CP031779
• Coordinates: 1989195..1990238 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CFBR-105
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1984195..1995238

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D1F65_RS10110 (D1F65_10110)	-	1984616..1985872 (-)	1257	WP_001795108.1	aminopeptidase	-
D1F65_RS10115 (D1F65_10115)	-	1985875..1986075 (-)	201	WP_000180460.1	DUF1128 family protein	-
D1F65_RS10120 (D1F65_10120)	-	1986222..1986686 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
D1F65_RS10125 (D1F65_10125)	-	1986693..1986968 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
D1F65_RS10130 (D1F65_10130)	-	1987246..1988463 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
D1F65_RS10135 (D1F65_10135)	vraR	1988576..1989205 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
D1F65_RS10140 (D1F65_10140)	vraS	1989195..1990238 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
D1F65_RS10145 (D1F65_10145)	liaF	1990235..1990936 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
D1F65_RS10150 (D1F65_10150)	-	1990951..1991337 (-)	387	WP_001110179.1	hypothetical protein	-
D1F65_RS10155 (D1F65_10155)	map	1991554..1992312 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
D1F65_RS10160 (D1F65_10160)	-	1992784..1993770 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
D1F65_RS10170 (D1F65_10170)	-	1994201..1994614 (-)	414	WP_001557448.1	hypothetical protein	-
D1F65_RS10175 (D1F65_10175)	-	1994643..1994753 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=311193 D1F65_RS10140 WP_001017131.1 1989195..1990238(-) (vraS) [Staphylococcus aureus strain CFBR-105]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=311193 D1F65_RS10140 WP_001017131.1 1989195..1990238(-) (vraS) [Staphylococcus aureus strain CFBR-105]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1