Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   ES300_RS00865 Genome accession   NZ_CP038251
Coordinates   166166..168115 (+) Length   649 a.a.
NCBI ID   WP_000018169.1    Uniprot ID   P0A3R1
Organism   Streptococcus pneumoniae strain TVO_1901944     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 161166..173115
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ES300_RS00840 (ES300_00885) - 161577..162683 (+) 1107 WP_000608719.1 pyridoxal-dependent decarboxylase -
  ES300_RS00845 (ES300_00890) - 162659..164050 (+) 1392 WP_000358548.1 hypothetical protein -
  ES300_RS00850 (ES300_00895) - 164047..165225 (+) 1179 WP_000792992.1 MFS transporter -
  ES300_RS10715 (ES300_00900) - 165263..165626 (+) 364 Protein_170 DeoR family transcriptional regulator -
  ES300_RS00855 (ES300_00905) - 165650..165883 (+) 234 WP_000623387.1 ROK family protein -
  ES300_RS00860 - 165849..165980 (-) 132 Protein_172 IS630 family transposase -
  ES300_RS00865 (ES300_00915) hexB 166166..168115 (+) 1950 WP_000018169.1 DNA mismatch repair endonuclease MutL Machinery gene
  ES300_RS00870 (ES300_00920) ribE 168440..168907 (-) 468 WP_001099502.1 6,7-dimethyl-8-ribityllumazine synthase -
  ES300_RS00875 (ES300_00925) - 168908..170111 (-) 1204 Protein_175 bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II -
  ES300_RS00880 (ES300_00930) ribE 170131..170766 (-) 636 WP_000493842.1 riboflavin synthase -
  ES300_RS00885 (ES300_00935) ribD 170751..171851 (-) 1101 WP_001284105.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
  ES300_RS00890 (ES300_00940) ruvA 172256..172849 (+) 594 WP_000271487.1 Holliday junction branch migration protein RuvA Machinery gene

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73434.89 Da        Isoelectric Point: 5.3001

>NTDB_id=310066 ES300_RS00865 WP_000018169.1 166166..168115(+) (hexB) [Streptococcus pneumoniae strain TVO_1901944]
MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKVQITDNGHGIAHDEVELALRRHATSK
IKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSE
AIANSLKEQTLIPDALENLAKSTVRNREKVEQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLTLFAKETLD
RLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCD
MLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=310066 ES300_RS00865 WP_000018169.1 166166..168115(+) (hexB) [Streptococcus pneumoniae strain TVO_1901944]
ATGTCTCATATTATTGAATTGCCAGAGATGCTGGCAAACCAAATCGCGGCTGGAGAGGTCATTGAACGTCCTGCCAGTGT
GGTCAAAGAGTTGGTAGAAAATGCCATTGACGCGGGCTCTAGTCAGATTATCATTGAGATTGAGGAAGCTGGTCTCAAGA
AGGTTCAAATCACGGATAACGGTCATGGAATTGCCCACGATGAGGTGGAGTTGGCCCTGCGTCGCCATGCGACCAGTAAG
ATAAAAAATCAAGCAGATCTCTTTCGGATTCGGACGCTTGGTTTTCGTGGTGAAGCCTTGCCTTCTATTGCGTCTGTTAG
TGTCTTGACTCTGTTAACGGCGGTGGATGGTGCTAGTCATGGAACCAAGTTAGTCGCGCGTGGGGGTGAAGTTGAGGAAG
TCATCCCAGCGACTAGTCCTGTGGGAACCAAGGTTTGTGTGGAGGATCTCTTTTTCAACACGCCTGCCCGTCTCAAGTAT
ATGAAGAGCCAGCAAGCGGAGTTGTCTCATATCATTGATATTGTCAACCGTCTGGGCTTGGCCCATCCTGAGATTTCTTT
TAGCTTGATTAGTGATGGCAAGGAAATGACGCGGACAGCAGGGACTGGTCAATTGCGCCAAGCAATCGCAGGGATTTACG
GTTTGGTCAGTGCCAAGAAGATGATTGAAATTGAGAACTCTGACCTAGATTTCGAAATTTCAGGTTTTGTGTCCTTGCCT
GAGTTGACTCGGGCTAACCGCAATTATATCAGCCTCTTCATCAATGGCCGTTATATTAAGAACTTCCTGCTCAATCGTGC
TATTTTGGATGGTTTTGGAAGCAAGCTTATGGTTGGACGTTTTCCACTGGCTGTCATTCACATCCATATCGACCCTTATC
TAGCGGATGTCAATGTGCATCCAACTAAGCAAGAGGTGCGGATTTCCAAGGAAAAAGAACTGATGACTCTGGTTTCAGAA
GCTATTGCAAATAGTCTCAAGGAACAAACCTTGATTCCAGATGCCTTGGAAAATCTTGCCAAATCGACCGTGCGCAATCG
TGAGAAGGTGGAGCAAACTATTCTCCCACTCAAAGAAAATACGCTCTACTATGAGAAAACTGAGCCGTCAAGACCTAGTC
AAACTGAAGTAGCTGATTATCAGGTAGAATTGACTGATGAAGGGCAGGATTTGACCCTGTTTGCCAAGGAAACCTTGGAC
CGATTGACCAAGCCAGCAAAACTGCATTTTGCAGAGAGAAAGCCTGCTAACTACGACCAGCTAGACCATCCAGAGTTAGA
TCTTGCTAGCATCGATAAGGCTTATGACAAACTGGAGCGAGAAGAAGCATCCAGCTTCCCAGAGTTGGAGTTTTTCGGAC
AAATGCACGGGACTTATCTCTTTGCCCAAGGGCGAGATGGACTTTACATCATAGATCAGCACGCTGCTCAGGAACGGGTC
AAGTACGAGGAGTACCGTGAAAGCATTGGCAATGTTGACCAGAGCCAGCAGCAACTCCTAGTGCCCTATATCTTTGAATT
TCCTGCGGATGATGCCCTGCGTCTCAAGGAAAGAATGCCTCTCTTAGAGGAAGTGGGCGTCTTTCTAGCAGAGTACGGAG
AAAATCAATTTATTCTACGTGAACATCCTATTTGGATGGCAGAAGAAGAGATTGAATCAGGCATCTATGAGATGTGCGAC
ATGCTCCTTTTGACCAAGGAAGTTTCTATCAAGAAATACCGAGCAGAGCTGGCTATCATGATGTCTTGCAAGCGATCTAT
CAAGGCCAATCATCGTATTGATGATCATTCAGCTAGACAACTCCTCTATCAGCTTTCTCAATGTGACAATCCCTATAACT
GTCCTCACGGACGTCCTGTTTTGGTGCATTTTACCAAGTCGGATATGGAAAAGATGTTCCGACGTATTCAGGAAAATCAC
ACCAGTCTCCGTGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-107)

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0A3R1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

100

100

1

Multiple sequence alignment