Detailed information NTG0309554

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DD545_RS09985
• Genome accession: NZ_CP031664
• Coordinates: 1943039..1944082 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 28
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1938039..1949082

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DD545_RS09955 (DD545_01803)	-	1938457..1939713 (-)	1257	WP_001795438.1	aminopeptidase	-
DD545_RS09960 (DD545_01804)	-	1939716..1939916 (-)	201	WP_000180461.1	DUF1128 family protein	-
DD545_RS09965 (DD545_01805)	-	1940063..1940527 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DD545_RS09970 (DD545_01806)	-	1940534..1940809 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DD545_RS09975 (DD545_01807)	-	1941087..1942304 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
DD545_RS09980 (DD545_01808)	vraR	1942420..1943049 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
DD545_RS09985 (DD545_01809)	vraS	1943039..1944082 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DD545_RS09990 (DD545_01810)	liaF	1944079..1944780 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DD545_RS09995 (DD545_01811)	-	1944795..1945181 (-)	387	WP_001110179.1	hypothetical protein	-
DD545_RS10000 (DD545_01812)	map	1945398..1946156 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
DD545_RS10010 (DD545_01813)	-	1946743..1947729 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
DD545_RS10025	-	1948278..1948625 (-)	348	Protein_1851	hypothetical protein	-
DD545_RS10030 (DD545_01815)	-	1948677..1948961 (+)	285	WP_000134547.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=309554 DD545_RS09985 WP_001017131.1 1943039..1944082(-) (vraS) [Staphylococcus aureus strain 28]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=309554 DD545_RS09985 WP_001017131.1 1943039..1944082(-) (vraS) [Staphylococcus aureus strain 28]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1