Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | DZR90_RS06055 | Genome accession | NZ_CP031629 |
| Coordinates | 1176545..1178350 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain MGAS28278 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1156386..1203349 | 1176545..1178350 | within | 0 |
Gene organization within MGE regions
Location: 1156386..1203349
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DZR90_RS05975 (DZR90_05965) | - | 1156424..1157698 (-) | 1275 | WP_011284930.1 | polysaccharide deacetylase family protein | - |
| DZR90_RS05980 (DZR90_05970) | - | 1157793..1159220 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| DZR90_RS05985 (DZR90_05975) | ptsP | 1159405..1161138 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| DZR90_RS05990 (DZR90_05980) | - | 1161143..1161406 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| DZR90_RS05995 (DZR90_05985) | - | 1161799..1162017 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| DZR90_RS06000 (DZR90_05990) | nrdE | 1162037..1164196 (+) | 2160 | WP_002993430.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| DZR90_RS06005 (DZR90_05995) | nrdF | 1164529..1165488 (+) | 960 | WP_011017933.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| DZR90_RS06010 (DZR90_06000) | - | 1165463..1166776 (+) | 1314 | WP_011284932.1 | chloride channel protein | - |
| DZR90_RS06015 (DZR90_06005) | - | 1166872..1168028 (+) | 1157 | Protein_1118 | IS3 family transposase | - |
| DZR90_RS06020 (DZR90_06010) | - | 1168122..1168817 (-) | 696 | WP_002989227.1 | type II CAAX endopeptidase family protein | - |
| DZR90_RS06025 (DZR90_06015) | - | 1168836..1169597 (-) | 762 | WP_002995753.1 | DUF3169 family protein | - |
| DZR90_RS06030 (DZR90_06020) | - | 1169594..1169809 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| DZR90_RS06035 (DZR90_06025) | alaS | 1170170..1172788 (-) | 2619 | WP_011284933.1 | alanine--tRNA ligase | - |
| DZR90_RS06040 (DZR90_06030) | prsA | 1173175..1174230 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| DZR90_RS06045 (DZR90_06035) | - | 1174293..1175000 (-) | 708 | WP_011284934.1 | O-methyltransferase | - |
| DZR90_RS06050 (DZR90_06040) | - | 1175066..1176262 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| DZR90_RS06055 (DZR90_06045) | pepF | 1176545..1178350 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| DZR90_RS06060 (DZR90_06050) | - | 1178363..1179325 (-) | 963 | WP_002995771.1 | competence protein CoiA | - |
| DZR90_RS06065 (DZR90_06055) | - | 1179620..1180336 (-) | 717 | WP_002989197.1 | pseudouridine synthase | - |
| DZR90_RS06070 (DZR90_06060) | nagB | 1180455..1181159 (-) | 705 | WP_021340997.1 | glucosamine-6-phosphate deaminase | - |
| DZR90_RS06075 (DZR90_06065) | queA | 1181361..1182389 (+) | 1029 | WP_011284937.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| DZR90_RS06080 (DZR90_06070) | - | 1182396..1183616 (+) | 1221 | WP_002989189.1 | DUF3114 domain-containing protein | - |
| DZR90_RS06085 (DZR90_06075) | - | 1183730..1184320 (-) | 591 | WP_002989185.1 | serine hydrolase | - |
| DZR90_RS06090 (DZR90_06080) | - | 1184317..1184565 (-) | 249 | WP_002989183.1 | serine hydrolase | - |
| DZR90_RS06095 (DZR90_06085) | - | 1184621..1184776 (-) | 156 | WP_002989180.1 | hypothetical protein | - |
| DZR90_RS06100 (DZR90_06090) | sodA | 1184943..1185548 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| DZR90_RS06105 (DZR90_06095) | holA | 1185645..1186685 (-) | 1041 | WP_002989176.1 | DNA polymerase III subunit delta | - |
| DZR90_RS06110 (DZR90_06100) | - | 1186756..1188998 (-) | 2243 | Protein_1137 | DNA internalization-related competence protein ComEC/Rec2 | - |
| DZR90_RS06115 (DZR90_06105) | - | 1188979..1189641 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| DZR90_RS06120 (DZR90_06110) | - | 1189841..1190581 (-) | 741 | WP_021340996.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | - |
| DZR90_RS06125 (DZR90_06115) | - | 1190699..1191475 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| DZR90_RS06130 (DZR90_06120) | - | 1191465..1191743 (+) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| DZR90_RS06135 (DZR90_06125) | - | 1191767..1193767 (-) | 2001 | WP_011284942.1 | potassium transporter Kup | - |
| DZR90_RS06140 (DZR90_06130) | - | 1193894..1195513 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| DZR90_RS06145 (DZR90_06135) | - | 1195820..1197364 (-) | 1545 | WP_011284943.1 | peptide chain release factor 3 | - |
| DZR90_RS06155 (DZR90_06145) | - | 1197612..1198307 (-) | 696 | WP_011017956.1 | TIGR02206 family membrane protein | - |
| DZR90_RS06160 (DZR90_06150) | murF | 1198387..1199778 (-) | 1392 | WP_010922441.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| DZR90_RS06165 (DZR90_06155) | - | 1199977..1201023 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| DZR90_RS06170 (DZR90_06160) | recR | 1201124..1201720 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| DZR90_RS09930 (DZR90_06165) | - | 1201767..1201958 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| DZR90_RS06180 (DZR90_06170) | - | 1202518..1203297 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=308638 DZR90_RS06055 WP_011054652.1 1176545..1178350(-) (pepF) [Streptococcus pyogenes strain MGAS28278]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=308638 DZR90_RS06055 WP_011054652.1 1176545..1178350(-) (pepF) [Streptococcus pyogenes strain MGAS28278]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |