Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   AB849_RS04125 Genome accession   NZ_CP036487
Coordinates   782065..784512 (-) Length   815 a.a.
NCBI ID   WP_049720819.1    Uniprot ID   -
Organism   Thermoactinomyces vulgaris strain CDF     
Function   degradation of ComK; degradation of DegU (predicted from homology)   
Competence regulation

Genomic Context

Location: 777065..789512
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AB849_RS04100 (AB849_004100) - 777384..777881 (-) 498 WP_231564634.1 CarD family transcriptional regulator -
  AB849_RS04105 (AB849_004105) - 778154..778549 (+) 396 WP_037996988.1 hypothetical protein -
  AB849_RS04110 (AB849_004110) pssA 778597..779307 (-) 711 WP_037996982.1 CDP-diacylglycerol--serine O-phosphatidyltransferase -
  AB849_RS04115 (AB849_004115) disA 779410..780438 (-) 1029 WP_049720835.1 DNA integrity scanning diadenylate cyclase DisA Machinery gene
  AB849_RS04120 (AB849_004120) radA/sms 780484..781857 (-) 1374 WP_037996979.1 DNA repair protein RadA Machinery gene
  AB849_RS04125 (AB849_004125) clpC 782065..784512 (-) 2448 WP_049720819.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  AB849_RS04130 (AB849_004130) - 784545..785621 (-) 1077 WP_037996974.1 protein arginine kinase -
  AB849_RS04135 (AB849_004135) - 785634..786152 (-) 519 WP_049720818.1 UvrB/UvrC motif-containing protein -
  AB849_RS04140 (AB849_004140) - 786159..786629 (-) 471 WP_049720817.1 CtsR family transcriptional regulator -
  AB849_RS04145 (AB849_004145) - 786766..787464 (-) 699 WP_037996966.1 MgtC/SapB family protein -
  AB849_RS04150 (AB849_004150) - 787588..788259 (-) 672 WP_049720816.1 HAD family hydrolase -
  AB849_RS04155 (AB849_004155) - 788391..789215 (+) 825 WP_049720834.1 sensor histidine kinase -

Sequence

Protein


Download         Length: 815 a.a.        Molecular weight: 91124.00 Da        Isoelectric Point: 6.4445

>NTDB_id=307885 AB849_RS04125 WP_049720819.1 782065..784512(-) (clpC) [Thermoactinomyces vulgaris strain CDF]
MMFGRFTERAQKVLALAQEEAVRLGHTNIGTEHVLLGLVREGEGIAAKALIGLGLGLEKIQKEVENLIGRGQGQPVNIAY
TPRAKKVIELSMDEARKLGHTYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGNSETFSNHSSTHHQVNT
PTLDGLARDLTAAAHDGNLDPVIGRSKEIERVIQVLSRRTKNNPVLIGEPGVGKTAVAEGLAQRIVDGEIPETLRNKRVM
TLDMGTVVAGTKYRGEFEDRLKKIMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPALARGELQCIGATTLDEY
RKYIEKDAALERRFQPILVEEPSTEEAVLILKGLRDRYEAHHRVKITDEAIEQAVRLSDRYITDRYLPDKAIDLIDEAAS
KVRLKSYMMPPELKKLEQKLEEVKKEKDAAVQSQEFEKAASLRDTEQKLREEIETNRNSWKQHQGKTDSEVTAEDIADVV
SSWTGIPVKKLAEEESERLLNMESILHNRVIGQEEAVRSVSRAIRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAE
AMFGDEDAMTRIDMSEYMEKHATSRLVGSPPGYVGYEEGGQLTEKVRRKPYSVVLFDEIEKAHPEVFNILLQVLEDGRLT
DGKGRVVDFRNTIIIMTSNVGASTIKKTSRLGFNVGGNQAEDDYEHMKQNVMEELKKTFRPEFLNRIDDVIVFHPLKEEH
LEEIVSLMVNQLRKRLVEQGIEFRLTDEAKRYLAKEGFDPSYGARPLRRAIQKNIEDRLSEELLRGNVARGNSVVIDVKD
GKLVVEKEESRSATQ

Nucleotide


Download         Length: 2448 bp        

>NTDB_id=307885 AB849_RS04125 WP_049720819.1 782065..784512(-) (clpC) [Thermoactinomyces vulgaris strain CDF]
ATGATGTTTGGACGTTTTACAGAACGGGCGCAAAAAGTTCTCGCCCTTGCTCAGGAAGAAGCCGTGCGTCTGGGACATAC
CAACATCGGAACGGAACATGTTTTGCTTGGATTGGTTCGCGAAGGGGAAGGGATTGCAGCCAAGGCCTTGATCGGTTTGG
GCCTGGGATTGGAAAAAATCCAAAAAGAAGTTGAGAATTTGATTGGACGGGGACAGGGGCAACCCGTAAACATTGCTTAT
ACGCCACGGGCGAAAAAAGTGATCGAATTGTCCATGGATGAAGCTCGCAAGTTGGGGCACACCTATGTCGGCACTGAGCA
CATTCTTCTCGGTTTGATTCGCGAGGGGGAAGGCGTGGCGGCCCGCGTTCTCAACAATTTGGGTGTGAGCTTGAACAAAG
CCCGCCAGCAGGTTTTGCAACTCTTGGGAAACAGCGAAACCTTCTCCAACCACTCCAGTACCCATCATCAGGTCAATACA
CCCACACTGGACGGCTTGGCCCGCGACTTGACGGCCGCTGCGCATGACGGAAACCTGGATCCGGTGATCGGCCGCAGTAA
AGAGATTGAGCGGGTGATTCAAGTCTTGTCCCGCCGGACCAAAAACAATCCGGTTTTGATCGGTGAACCGGGAGTCGGAA
AAACGGCGGTTGCCGAAGGTTTGGCCCAGCGCATTGTTGACGGGGAAATCCCGGAAACCTTGCGCAACAAGCGGGTTATG
ACCCTGGATATGGGAACGGTGGTGGCCGGAACGAAATATCGCGGTGAGTTTGAAGACCGGTTGAAAAAAATCATGGATGA
AATCCGCCAAGCCGGAAACATCATCTTGTTCATTGATGAGTTGCACACGTTGATCGGGGCGGGAGGTGCCGAAGGAGCGA
TTGACGCATCCAATATCCTGAAACCGGCGCTTGCCCGTGGGGAATTGCAATGTATCGGTGCGACAACCCTGGATGAATAC
CGGAAATACATCGAGAAAGATGCCGCTTTGGAGCGCCGTTTCCAACCGATTTTGGTGGAAGAGCCGAGCACTGAGGAAGC
GGTGTTGATCCTGAAAGGTTTGAGGGATCGTTACGAAGCCCATCACCGGGTGAAAATCACCGATGAAGCGATTGAACAAG
CGGTGAGATTATCCGACCGCTATATTACGGACCGGTATTTGCCGGATAAAGCGATTGACCTGATCGATGAAGCGGCATCC
AAAGTGCGGTTGAAATCTTACATGATGCCGCCGGAACTGAAAAAACTGGAACAAAAGCTGGAAGAAGTGAAAAAAGAAAA
AGACGCGGCCGTGCAAAGCCAGGAATTTGAAAAAGCGGCTTCTTTGAGGGATACCGAGCAAAAATTGCGTGAGGAAATCG
AGACCAACCGGAATTCCTGGAAACAACACCAAGGAAAAACCGATTCCGAAGTCACCGCGGAAGATATTGCCGATGTCGTT
TCAAGCTGGACGGGAATTCCTGTGAAGAAGTTGGCGGAAGAAGAATCGGAACGCTTGTTGAATATGGAGTCCATCCTGCA
TAACCGCGTCATCGGACAAGAGGAAGCGGTCCGTTCCGTTTCCCGTGCCATCCGCCGGGCCCGTGCAGGATTGAAAGATC
CGAAGCGGCCGATCGGTTCCTTCATCTTCCTGGGACCGACCGGAGTCGGAAAAACCGAATTGGCCCGTGCTTTGGCGGAA
GCCATGTTTGGTGACGAAGATGCGATGACCCGGATTGACATGTCTGAGTATATGGAAAAACATGCGACGAGCCGTCTTGT
CGGTTCGCCTCCGGGATACGTGGGATATGAAGAAGGAGGACAATTGACGGAAAAAGTCCGCCGGAAACCCTATTCGGTCG
TCCTGTTTGACGAAATCGAAAAAGCTCACCCGGAAGTTTTCAACATCTTGTTGCAAGTGCTGGAAGACGGCCGGTTGACG
GACGGAAAAGGCAGGGTGGTGGATTTTCGTAACACCATCATCATCATGACTTCCAACGTGGGGGCATCCACCATCAAGAA
AACGTCACGCCTCGGATTTAACGTTGGCGGCAATCAAGCGGAAGATGACTATGAACACATGAAGCAAAATGTCATGGAAG
AGCTGAAGAAAACTTTCCGTCCCGAGTTTTTGAACCGGATCGACGATGTGATTGTTTTCCATCCTTTGAAAGAAGAGCAT
CTGGAAGAGATCGTGTCCCTGATGGTGAACCAATTGCGCAAACGCCTGGTTGAACAGGGAATCGAATTCCGGTTGACGGA
TGAAGCCAAACGTTACTTGGCGAAAGAAGGATTTGACCCGAGCTACGGTGCCCGCCCGTTGCGCCGGGCCATCCAGAAAA
ACATCGAAGACCGTTTGTCCGAAGAGTTGTTGCGCGGCAATGTCGCACGCGGGAACTCGGTGGTCATCGATGTGAAAGAC
GGAAAATTGGTTGTCGAAAAAGAAGAGTCCCGGTCTGCAACCCAATGA

Domains

Predicted by InterProScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(205-320)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(17-69)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(93-143)

AAA domain (Cdc48 subfamily) (AAA_2)

(536-709)

AAA lid domain (AAA_lid_9)

(343-444)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(716-795)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Bacillus subtilis subsp. subtilis str. 168

78.784

98.896

0.779
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

49.199

99.509

0.49
  clpC Streptococcus thermophilus LMD-9

46.373

100

0.479
  clpC Streptococcus thermophilus LMG 18311

46.136

100

0.476
  clpC Streptococcus mutans UA159

45.553

100

0.465
  clpC Streptococcus pneumoniae D39

46.56

99.877

0.465
  clpC Streptococcus pneumoniae Rx1

46.56

99.877

0.465
  clpC Streptococcus pneumoniae TIGR4

46.437

99.877

0.464
  clpE Streptococcus mutans UA159

53.907

76.933

0.415
  clpC Lactococcus lactis subsp. cremoris KW2

51.145

80.368

0.411
  clpE Streptococcus pneumoniae Rx1

52.564

76.564

0.402
  clpE Streptococcus pneumoniae D39

52.564

76.564

0.402
  clpE Streptococcus pneumoniae R6

52.564

76.564

0.402
  clpE Streptococcus pneumoniae TIGR4

52.396

76.81

0.402

Multiple sequence alignment