Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | DNI27_RS05305 | Genome accession | NZ_CP031603 |
| Coordinates | 1124284..1125633 (-) | Length | 449 a.a. |
| NCBI ID | WP_140239121.1 | Uniprot ID | A0A0S4I3Q4 |
| Organism | Staphylococcus pseudintermedius strain AK9 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 1073870..1130057 | 1124284..1125633 | within | 0 |
Gene organization within MGE regions
Location: 1073870..1130057
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DNI27_RS05065 (DNI27_05180) | mecA | 1073870..1075879 (-) | 2010 | WP_063852655.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| DNI27_RS05070 (DNI27_05185) | mecR1 | 1075976..1077733 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| DNI27_RS05075 (DNI27_05190) | mecI | 1077733..1078104 (+) | 372 | WP_025904161.1 | mecA-type methicillin resistance repressor MecI | - |
| DNI27_RS05080 (DNI27_05195) | psm-mec | 1078189..1078257 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| DNI27_RS05085 (DNI27_05200) | - | 1078577..1079725 (+) | 1149 | WP_075773656.1 | ROK family transcriptional regulator | - |
| DNI27_RS05090 (DNI27_05210) | cstB | 1079839..1081173 (-) | 1335 | Protein_1005 | persulfide dioxygenase-sulfurtransferase CstB | - |
| DNI27_RS05095 (DNI27_05215) | - | 1081206..1082270 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| DNI27_RS05100 (DNI27_05220) | cstR | 1082406..1082666 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| DNI27_RS05105 (DNI27_05225) | - | 1082666..1083304 (+) | 639 | Protein_1008 | sulfite exporter TauE/SafE family protein | - |
| DNI27_RS05115 (DNI27_05235) | - | 1083578..1084195 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| DNI27_RS05120 (DNI27_05240) | - | 1084276..1086690 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| DNI27_RS05125 (DNI27_05245) | - | 1086683..1087048 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| DNI27_RS05130 (DNI27_05250) | - | 1087286..1087663 (-) | 378 | WP_140239103.1 | DUF6262 family protein | - |
| DNI27_RS05135 (DNI27_05255) | - | 1087670..1089562 (-) | 1893 | WP_002485298.1 | site-specific integrase | - |
| DNI27_RS05140 (DNI27_05260) | - | 1089757..1090080 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| DNI27_RS05145 (DNI27_05265) | - | 1090073..1090279 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| DNI27_RS05150 (DNI27_05270) | - | 1090281..1090802 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| DNI27_RS05155 (DNI27_05275) | - | 1090821..1091132 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| DNI27_RS05160 (DNI27_05285) | - | 1091217..1091567 (-) | 351 | WP_140239104.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| DNI27_RS05165 (DNI27_05290) | - | 1092138..1092872 (-) | 735 | WP_075100305.1 | glucose 1-dehydrogenase | - |
| DNI27_RS05170 (DNI27_05295) | ccrB | 1092960..1094588 (-) | 1629 | WP_140239105.1 | cassette chromosome recombinase CcrB | Machinery gene |
| DNI27_RS05175 (DNI27_05300) | ccrA | 1094609..1095958 (-) | 1350 | WP_140239106.1 | cassette chromosome recombinase CcrA | Machinery gene |
| DNI27_RS05180 (DNI27_05305) | - | 1096136..1096393 (-) | 258 | WP_058332293.1 | hypothetical protein | - |
| DNI27_RS05185 (DNI27_05310) | cch1 | 1096456..1098246 (-) | 1791 | WP_140239107.1 | cassette chromosome replicative helicase | - |
| DNI27_RS05190 (DNI27_05315) | - | 1098372..1099799 (-) | 1428 | WP_140239108.1 | DUF6038 family protein | - |
| DNI27_RS05195 (DNI27_05320) | - | 1100016..1101179 (+) | 1164 | WP_103388710.1 | ATP-binding protein | - |
| DNI27_RS05200 (DNI27_05325) | - | 1101325..1101981 (+) | 657 | WP_257976475.1 | hypothetical protein | - |
| DNI27_RS05205 (DNI27_05330) | - | 1102118..1102743 (+) | 626 | Protein_1027 | type I restriction endonuclease | - |
| DNI27_RS13505 | - | 1102767..1103537 (+) | 771 | WP_257976476.1 | HNH endonuclease | - |
| DNI27_RS05215 | - | 1103834..1104007 (-) | 174 | WP_180932474.1 | hypothetical protein | - |
| DNI27_RS05220 (DNI27_05340) | - | 1105203..1105847 (+) | 645 | WP_206665915.1 | hypothetical protein | - |
| DNI27_RS05225 (DNI27_05345) | - | 1105897..1106901 (-) | 1005 | WP_140239109.1 | hypothetical protein | - |
| DNI27_RS05230 (DNI27_05350) | - | 1106930..1108255 (-) | 1326 | WP_140239110.1 | TcaA second domain-containing protein | - |
| DNI27_RS05235 (DNI27_05355) | - | 1108278..1108595 (-) | 318 | WP_140239111.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| DNI27_RS05240 (DNI27_05360) | - | 1108598..1108846 (-) | 249 | WP_140239112.1 | AbrB family transcriptional regulator | - |
| DNI27_RS05245 (DNI27_05365) | - | 1108962..1110041 (+) | 1080 | WP_140239113.1 | AbiH family protein | - |
| DNI27_RS13510 | - | 1110220..1110309 (-) | 90 | Protein_1036 | putative holin-like toxin | - |
| DNI27_RS05250 (DNI27_05375) | - | 1112038..1113858 (+) | 1821 | WP_189695520.1 | DNA/RNA helicase domain-containing protein | - |
| DNI27_RS05255 (DNI27_05380) | - | 1114069..1116861 (+) | 2793 | WP_140239115.1 | type I restriction endonuclease subunit R | - |
| DNI27_RS05260 (DNI27_05385) | - | 1116951..1117532 (+) | 582 | WP_140239116.1 | restriction endonuclease subunit S | - |
| DNI27_RS05265 (DNI27_05390) | - | 1117533..1119089 (+) | 1557 | WP_189695521.1 | type I restriction-modification system subunit M | - |
| DNI27_RS13515 (DNI27_05395) | - | 1119082..1120305 (+) | 1224 | WP_140239118.1 | restriction endonuclease subunit S | - |
| DNI27_RS05275 (DNI27_05400) | - | 1120354..1120602 (+) | 249 | WP_140239119.1 | hypothetical protein | - |
| DNI27_RS05280 | - | 1120666..1120887 (-) | 222 | WP_189909949.1 | hypothetical protein | - |
| DNI27_RS05285 (DNI27_05405) | - | 1120902..1121405 (-) | 504 | WP_140239120.1 | DUF1643 domain-containing protein | - |
| DNI27_RS05290 (DNI27_05410) | - | 1121420..1121731 (-) | 312 | WP_031912426.1 | DUF960 family protein | - |
| DNI27_RS05295 (DNI27_05415) | - | 1121827..1122165 (-) | 339 | WP_069995843.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| DNI27_RS05300 (DNI27_05420) | ccrB | 1122634..1124262 (-) | 1629 | WP_031912428.1 | cassette chromosome recombinase CcrB | Machinery gene |
| DNI27_RS05305 (DNI27_05425) | ccrA | 1124284..1125633 (-) | 1350 | WP_140239121.1 | cassette chromosome recombinase CcrA | Machinery gene |
| DNI27_RS05310 (DNI27_05430) | - | 1125822..1126451 (-) | 630 | Protein_1049 | hypothetical protein | - |
| DNI27_RS13520 (DNI27_05435) | - | 1126460..1126798 (+) | 339 | Protein_1050 | recombinase family protein | - |
| DNI27_RS05315 (DNI27_05440) | - | 1126910..1127269 (-) | 360 | WP_001631039.1 | hypothetical protein | - |
| DNI27_RS05320 (DNI27_05445) | - | 1127476..1127802 (+) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| DNI27_RS05325 (DNI27_05455) | - | 1128132..1130057 (+) | 1926 | WP_017175150.1 | heavy metal translocating P-type ATPase | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52289.76 Da Isoelectric Point: 9.8965
>NTDB_id=307791 DNI27_RS05305 WP_140239121.1 1124284..1125633(-) (ccrA) [Staphylococcus pseudintermedius strain AK9]
MKQAIGYLRQSTTKQQSLAAQKQTIKALAEKNNIQHITFYSDKQSGRTDKRNGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQTYHVHILSVHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGIKEKARQGKLITTHAPFGYHYH
NGTFTIDTVKAPTVKAVFNYYLQGYGYKKIAQYLEADDNFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVIRTQKQVKRKPSENQLKQKIKCPYCHSTLTNMTVRKPNHSLRYYVCPQNMNNARFVCEFKGINAQELETSVLAT
CQDFFQNQQLYSKINHTIQQRLKRQRDVETKTTLNHEQLIEKLAQGKIDAETFREQTQSLHQQSKPISSISAYQIRKAFQ
NIIQQRFTLNMLYPYIDEINISKNKSLAGIYFKNEPLNIVNQTTQSSIA
MKQAIGYLRQSTTKQQSLAAQKQTIKALAEKNNIQHITFYSDKQSGRTDKRNGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQTYHVHILSVHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGIKEKARQGKLITTHAPFGYHYH
NGTFTIDTVKAPTVKAVFNYYLQGYGYKKIAQYLEADDNFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVIRTQKQVKRKPSENQLKQKIKCPYCHSTLTNMTVRKPNHSLRYYVCPQNMNNARFVCEFKGINAQELETSVLAT
CQDFFQNQQLYSKINHTIQQRLKRQRDVETKTTLNHEQLIEKLAQGKIDAETFREQTQSLHQQSKPISSISAYQIRKAFQ
NIIQQRFTLNMLYPYIDEINISKNKSLAGIYFKNEPLNIVNQTTQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=307791 DNI27_RS05305 WP_140239121.1 1124284..1125633(-) (ccrA) [Staphylococcus pseudintermedius strain AK9]
ATGAAACAAGCAATTGGTTACTTACGACAGAGCACTACAAAGCAACAATCCTTAGCAGCACAAAAACAAACCATCAAGGC
ATTAGCCGAAAAAAATAATATTCAACACATTACCTTTTATAGCGATAAACAATCAGGACGTACTGATAAGCGGAATGGTT
ATCAACAAATTACTGAACTGATTCAACAGGGACAATGTGACGTATTATGTTGCTATCGTCTAAATCGACTTCATCGTAAT
CTAAAAAATGCATTAAAGCTCATGAAATTATGTCAAACGTATCATGTTCATATCTTAAGCGTTCATGATGGCTACTTCGA
CATGGATAAAGCATTCGATCGGCTCAAACTCAATATTTTCATCAGCTTGGCCGAACTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCGAGACAAGGTAAACTAATTACAACACATGCACCCTTTGGGTATCACTATCAT
AATGGTACTTTCACGATAGACACAGTAAAAGCACCAACAGTAAAAGCTGTGTTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCGCAATACTTAGAAGCTGATGATAACTTCATTAATCGTAAGCCCTATCAAGTGCGTAATATTATCCTTA
ACCCTAATTACTGTGGCCGTGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTATCCGAACTCAGAAACAAGTCAAACGTAAGCCGTCAGAAAATCAACTCAAACAAAAAATCAA
ATGTCCCTATTGCCATTCGACACTCACAAACATGACCGTCCGAAAACCAAATCATTCATTGCGTTACTATGTCTGTCCGC
AAAATATGAATAACGCTCGCTTTGTTTGTGAATTTAAAGGAATCAACGCACAAGAATTAGAAACAAGTGTTTTAGCGACT
TGTCAGGACTTCTTTCAAAATCAACAGCTCTATTCAAAAATAAACCATACTATTCAACAACGACTCAAAAGACAAAGAGA
TGTAGAAACTAAAACTACACTCAATCACGAGCAGCTGATAGAAAAATTAGCCCAAGGCAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACATCAACAATCAAAACCTATATCATCAATCAGTGCGTATCAAATTCGAAAAGCTTTCCAA
AACATCATTCAACAACGTTTCACGCTAAACATGTTGTACCCCTATATTGATGAAATTAATATTTCTAAAAATAAAAGCCT
CGCTGGCATCTATTTCAAAAATGAACCTCTAAACATTGTCAATCAAACGACGCAATCATCGATTGCTTAA
ATGAAACAAGCAATTGGTTACTTACGACAGAGCACTACAAAGCAACAATCCTTAGCAGCACAAAAACAAACCATCAAGGC
ATTAGCCGAAAAAAATAATATTCAACACATTACCTTTTATAGCGATAAACAATCAGGACGTACTGATAAGCGGAATGGTT
ATCAACAAATTACTGAACTGATTCAACAGGGACAATGTGACGTATTATGTTGCTATCGTCTAAATCGACTTCATCGTAAT
CTAAAAAATGCATTAAAGCTCATGAAATTATGTCAAACGTATCATGTTCATATCTTAAGCGTTCATGATGGCTACTTCGA
CATGGATAAAGCATTCGATCGGCTCAAACTCAATATTTTCATCAGCTTGGCCGAACTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCGAGACAAGGTAAACTAATTACAACACATGCACCCTTTGGGTATCACTATCAT
AATGGTACTTTCACGATAGACACAGTAAAAGCACCAACAGTAAAAGCTGTGTTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCGCAATACTTAGAAGCTGATGATAACTTCATTAATCGTAAGCCCTATCAAGTGCGTAATATTATCCTTA
ACCCTAATTACTGTGGCCGTGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTATCCGAACTCAGAAACAAGTCAAACGTAAGCCGTCAGAAAATCAACTCAAACAAAAAATCAA
ATGTCCCTATTGCCATTCGACACTCACAAACATGACCGTCCGAAAACCAAATCATTCATTGCGTTACTATGTCTGTCCGC
AAAATATGAATAACGCTCGCTTTGTTTGTGAATTTAAAGGAATCAACGCACAAGAATTAGAAACAAGTGTTTTAGCGACT
TGTCAGGACTTCTTTCAAAATCAACAGCTCTATTCAAAAATAAACCATACTATTCAACAACGACTCAAAAGACAAAGAGA
TGTAGAAACTAAAACTACACTCAATCACGAGCAGCTGATAGAAAAATTAGCCCAAGGCAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACATCAACAATCAAAACCTATATCATCAATCAGTGCGTATCAAATTCGAAAAGCTTTCCAA
AACATCATTCAACAACGTTTCACGCTAAACATGTTGTACCCCTATATTGATGAAATTAATATTTCTAAAAATAAAAGCCT
CGCTGGCATCTATTTCAAAAATGAACCTCTAAACATTGTCAATCAAACGACGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
94.209 |
100 |
0.942 |
| ccrA | Staphylococcus aureus N315 |
75.278 |
100 |
0.753 |