Detailed information NTG0306354

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: DK237_RS07695
• Genome accession: NZ_CP031377
• Coordinates: 1528358..1530586 (+)
• Length: 742 a.a.
• NCBI ID: WP_024409218.1
• Uniprot ID: A0A7Y6RRN2
• Organism: Streptococcus suis strain ISU2614
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1523358..1535586

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DK237_RS07670 (DK237_07900)	-	1523653..1523946 (-)	294	WP_002938694.1	hypothetical protein	-
DK237_RS07675 (DK237_07910)	-	1525384..1526232 (-)	849	WP_002938697.1	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	-
DK237_RS07680 (DK237_07915)	-	1526362..1527096 (-)	735	WP_002938699.1	amino acid ABC transporter ATP-binding protein	-
DK237_RS07685 (DK237_07920)	-	1527089..1527778 (-)	690	WP_002938702.1	amino acid ABC transporter permease	-
DK237_RS07690 (DK237_07925)	-	1527904..1528134 (-)	231	WP_002938704.1	DUF1797 family protein	-
DK237_RS07695 (DK237_07930)	clpE	1528358..1530586 (+)	2229	WP_024409218.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
DK237_RS07700 (DK237_07935)	-	1530772..1531233 (+)	462	WP_002938708.1	NUDIX hydrolase	-
DK237_RS07705 (DK237_07940)	-	1531288..1531596 (+)	309	WP_002938710.1	DUF1827 family protein	-
DK237_RS07710 (DK237_07945)	-	1532173..1533375 (+)	1203	WP_002935295.1	IS110-like element ISSsu7 family transposase	-

Sequence

Protein

• Length: 742 a.a.
• Molecular weight: 82682.02 Da
• Isoelectric Point: 5.2167

>NTDB_id=306354 DK237_RS07695 WP_024409218.1 1528358..1530586(+) (clpE) [Streptococcus suis strain ISU2614]
MLCKNCNINDATIHLYNNLNGKQQQVDLCHNCYQIMKTDPNNAILRGLGDLTNPNNMDPFSEFFNHLGGYPGNTPAGKNR
EQTPPTQAGEHNGRGGQTPPPQQPQQPNGLLEEFGINVTEIARRGDIDPVIGRDQEITRVIEILNRRTKNNPVLIGEPGV
GKTAVVEGLAQKIVDGDVPQKLRDKEVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRREIILFIDEIHEIVGAGSAGD
GNMDAGNILKPALARGEMQLVGATTLNEYRIIEKDAALERRMQPVKVEEPSVEETITILKGIQNKYQDYHHVKYSDAAIE
AAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFIDPKEIDQRLIDAENRKAQATRDEDYEKAAYFRDQIAKYKEMQK
ATISEEDIPLITEKEIEAIVEQKTNIPVGDLKEKEQSQLVNLASDLKAHVIGQDEAVDKIAKAIRRNRVGLGAPNRPIGS
FLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLDEVE
KAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAMEGRTQSVLGQLSNFFTPEFMNRFDG
IIEFQPLSKENLLEIVSLMLDDVNKRLSHNGISLHVTDKVKEKLVDLGYDPKMGARPLRRTIQDQIEDAITDFYLEHPAE
KDLRAVMSSKGTIQIKAQTKTK

Nucleotide

• Length: 2229 bp

>NTDB_id=306354 DK237_RS07695 WP_024409218.1 1528358..1530586(+) (clpE) [Streptococcus suis strain ISU2614]
ATGCTCTGCAAAAATTGTAATATCAACGACGCAACGATCCATCTCTACAACAACTTAAACGGTAAACAGCAGCAGGTAGA
CCTCTGTCACAACTGCTACCAAATCATGAAAACAGACCCTAATAATGCCATCCTACGTGGGTTGGGAGATTTAACAAATC
CTAACAACATGGATCCCTTTAGTGAATTTTTCAATCACCTAGGTGGCTATCCTGGCAATACCCCTGCTGGAAAAAATCGC
GAACAGACTCCTCCTACTCAAGCCGGTGAGCATAATGGACGTGGTGGACAGACCCCTCCTCCGCAACAACCCCAACAACC
AAATGGGCTCCTTGAAGAATTTGGTATCAACGTTACCGAAATTGCCCGTCGTGGGGATATTGATCCAGTAATCGGTCGCG
ATCAAGAAATTACCCGTGTCATCGAAATTCTCAACCGTCGTACAAAAAACAACCCTGTTCTTATCGGTGAGCCTGGTGTA
GGTAAAACAGCGGTTGTTGAAGGCTTGGCTCAAAAAATTGTCGATGGCGATGTCCCACAGAAATTACGAGACAAGGAAGT
CATTCGTCTGGATGTTGTCAGCCTCGTACAAGGAACAGGTATCCGTGGACAATTTGAAGAACGCATGCAAAAACTCATGG
AAGAAATCCGTAATCGTCGCGAAATCATTCTTTTTATTGACGAGATTCACGAAATTGTCGGTGCTGGCTCTGCAGGCGAT
GGTAACATGGATGCAGGCAATATCCTCAAACCAGCCCTCGCACGTGGTGAAATGCAACTAGTCGGTGCAACAACGCTCAA
CGAGTACCGTATTATCGAAAAAGATGCCGCCCTAGAACGCCGTATGCAACCTGTAAAAGTTGAAGAACCAAGTGTCGAAG
AAACCATTACCATTCTCAAAGGTATCCAAAATAAATACCAGGATTACCATCATGTTAAATACTCCGATGCTGCTATCGAA
GCTGCCGCAGTACTGTCCAACCGCTACATTCAAGACCGTTTCCTACCAGACAAAGCTATTGACCTTCTGGATGAAGCTGG
TTCAAAAATGAATTTAACCCTCAACTTTATTGATCCAAAGGAAATTGACCAACGCCTGATTGATGCCGAAAATCGGAAAG
CACAAGCTACACGGGATGAGGACTATGAAAAAGCGGCCTATTTCCGTGACCAAATTGCTAAGTACAAGGAGATGCAAAAG
GCAACTATCAGCGAGGAAGATATTCCACTCATTACTGAAAAAGAAATTGAGGCCATCGTTGAGCAAAAAACAAATATCCC
AGTTGGTGATTTAAAAGAAAAGGAACAGTCCCAGCTTGTGAACCTCGCTAGTGACTTAAAAGCCCATGTTATCGGACAAG
ATGAAGCAGTTGACAAGATAGCTAAAGCCATCCGCCGTAATCGTGTCGGTCTCGGTGCTCCAAATCGTCCCATTGGATCC
TTCCTCTTTGTCGGACCAACAGGTGTCGGTAAAACCGAATTGTCTAAACAATTAGCTATCGAACTCTTCGGTTCGGCAGA
CAGCATGATCCGCTTCGACATGTCCGAATACATGGAAAAACACGCTGTCGCTAAACTCGTCGGAGCTCCTCCAGGCTATG
TAGGCTATGAGGAGGCTGGACAATTGACAGAAAAAGTCCGTCGTAATCCTTACTCACTCATCCTCCTTGACGAAGTTGAA
AAAGCCCACCCAGATGTCATGCACATGTTCCTTCAGGTCTTAGACGATGGTCGTCTGACAGATGGACAAGGTCGGACAGT
CAGCTTCAAAGATACTATTATCATCATGACATCAAATGCTGGTACTGGAAAAGTTGAAGCAAGTGTCGGTTTTGGTGCGG
CTATGGAAGGGCGGACTCAATCAGTCCTTGGCCAACTTAGCAATTTCTTCACACCTGAATTTATGAACCGATTTGACGGT
ATTATTGAGTTCCAACCACTGAGCAAGGAAAACCTACTTGAAATCGTCAGCCTCATGCTAGACGATGTAAACAAACGCCT
TTCTCACAATGGCATCAGCCTCCATGTAACAGATAAAGTTAAGGAGAAATTAGTGGACCTTGGCTACGATCCAAAGATGG
GAGCTCGTCCACTGCGCAGAACCATCCAAGATCAGATTGAAGATGCTATCACCGACTTCTACTTAGAACATCCAGCAGAA
AAAGACCTACGTGCTGTCATGTCAAGTAAAGGTACAATTCAAATCAAGGCACAAACAAAGACAAAATAA

Domains

Predicted by InterproScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (153-272)

• AAA domain (Cdc48 subfamily) (AAA_2) (476-639)

• AAA lid domain (AAA_lid_9) (291-389)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (647-721)

3D structure

• AlphaFold DB: A0A7Y6RRN2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus pneumoniae Rx1	82.095	100	0.834
clpE	Streptococcus pneumoniae D39	82.095	100	0.834
clpE	Streptococcus pneumoniae R6	82.095	100	0.834
clpE	Streptococcus pneumoniae TIGR4	82.095	100	0.834
clpE	Streptococcus mutans UA159	82.243	100	0.83
clpC	Lactococcus lactis subsp. cremoris KW2	77.379	97.709	0.756
clpC	Bacillus subtilis subsp. subtilis str. 168	52.462	87.601	0.46
clpC	Streptococcus mutans UA159	48.558	84.097	0.408
clpC	Streptococcus thermophilus LMD-9	48.248	84.636	0.408
clpC	Streptococcus thermophilus LMG 18311	47.93	84.636	0.406
clpC	Streptococcus pneumoniae Rx1	47.84	84.232	0.403
clpC	Streptococcus pneumoniae D39	47.84	84.232	0.403
clpC	Streptococcus pneumoniae TIGR4	47.84	84.232	0.403
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.815	84.636	0.396