Detailed information NTG0304678

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DV131_RS01470
• Genome accession: NZ_CP031246
• Coordinates: 262549..263586 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain M26368
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 257549..268586

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DV131_RS01445	-	258288..259619 (-)	1332	WP_000390042.1	hemolysin family protein	-
DV131_RS01450	endA	259910..260734 (-)	825	WP_001036783.1	DNA-entry nuclease EndA	Machinery gene
DV131_RS01455	-	260773..260961 (-)	189	WP_001812859.1	DNA-directed RNA polymerase subunit beta	-
DV131_RS01460	murA	260954..262237 (-)	1284	WP_000358027.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
DV131_RS01465	-	262261..262491 (-)	231	WP_000615437.1	DUF1146 family protein	-
DV131_RS01470	sepM	262549..263586 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
DV131_RS01475	coaD	263570..264058 (-)	489	WP_001280769.1	pantetheine-phosphate adenylyltransferase	-
DV131_RS01480	rsmD	264048..264587 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DV131_RS01485	asnA	264652..265644 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
DV131_RS01495	-	265756..266439 (-)	684	WP_001016913.1	Bax inhibitor-1/YccA family protein	-
DV131_RS01500	-	266495..267235 (-)	741	WP_000152693.1	RNA methyltransferase	-
DV131_RS01505	-	267269..267547 (+)	279	WP_001174613.1	acylphosphatase	-
DV131_RS01510	yidC	267625..268551 (+)	927	WP_000835955.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=304678 DV131_RS01470 WP_000727277.1 262549..263586(-) (sepM) [Streptococcus pneumoniae strain M26368]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=304678 DV131_RS01470 WP_000727277.1 262549..263586(-) (sepM) [Streptococcus pneumoniae strain M26368]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACCTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591