Detailed information NTG0304603

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DV119_RS01375
• Genome accession: NZ_CP031245
• Coordinates: 231996..233033 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain M16808
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 226996..238033

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DV119_RS01350	-	227735..229066 (-)	1332	WP_000390039.1	hemolysin family protein	-
DV119_RS01355	endA	229357..230181 (-)	825	WP_001036791.1	DNA-entry nuclease EndA	Machinery gene
DV119_RS01360	-	230220..230408 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
DV119_RS01365	murA	230401..231684 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
DV119_RS01370	-	231708..231938 (-)	231	WP_000250393.1	DUF1146 family protein	-
DV119_RS01375	sepM	231996..233033 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
DV119_RS01380	coaD	233017..233505 (-)	489	WP_050221168.1	pantetheine-phosphate adenylyltransferase	-
DV119_RS01385	rsmD	233495..234034 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DV119_RS01390	asnA	234099..235091 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
DV119_RS01400	-	235203..235886 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
DV119_RS01405	-	235942..236682 (-)	741	WP_000152692.1	TrmH family RNA methyltransferase	-
DV119_RS01410	-	236716..236994 (+)	279	WP_001174613.1	acylphosphatase	-
DV119_RS01415	yidC	237072..237998 (+)	927	WP_000835949.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=304603 DV119_RS01375 WP_000727277.1 231996..233033(-) (sepM) [Streptococcus pneumoniae strain M16808]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=304603 DV119_RS01375 WP_000727277.1 231996..233033(-) (sepM) [Streptococcus pneumoniae strain M16808]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAATTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591