Detailed information NTG0303312

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: ETT47_RS08435
• Genome accession: NZ_CP035452
• Coordinates: 1703057..1705612 (-)
• Length: 851 a.a.
• NCBI ID: WP_136099144.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm123
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1698057..1710612

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT47_RS08415 (ETT47_08405)	-	1698547..1699107 (-)	561	WP_136098684.1	DNA-3-methyladenine glycosylase I	-
ETT47_RS08420 (ETT47_08410)	ruvA	1699117..1699713 (-)	597	WP_002992186.1	Holliday junction branch migration protein RuvA	Machinery gene
ETT47_RS08425 (ETT47_08415)	-	1699715..1700935 (-)	1221	WP_136026284.1	MFS transporter	-
ETT47_RS08430 (ETT47_08420)	hexB	1700946..1702928 (-)	1983	WP_136026283.1	DNA mismatch repair endonuclease MutL	Machinery gene
ETT47_RS08435 (ETT47_08425)	hexA	1703057..1705612 (-)	2556	WP_136099144.1	DNA mismatch repair protein MutS	Machinery gene
ETT47_RS09085	-	1705599..1705951 (-)	353	Protein_1559	YlbF family regulator	-
ETT47_RS08445 (ETT47_08435)	argR	1705948..1706385 (-)	438	WP_002982171.1	arginine repressor	-
ETT47_RS08450 (ETT47_08440)	argS	1706676..1708367 (+)	1692	WP_136099143.1	arginine--tRNA ligase	-
ETT47_RS08455 (ETT47_08445)	-	1708455..1708763 (+)	309	WP_012561077.1	bacteriocin immunity protein	-
ETT47_RS08460 (ETT47_08450)	-	1708790..1709662 (-)	873	WP_002982164.1	YitT family protein	-
ETT47_RS08465 (ETT47_08455)	-	1709705..1710583 (-)	879	WP_109991640.1	YitT family protein	-

Sequence

Protein

• Length: 851 a.a.
• Molecular weight: 95419.93 Da
• Isoelectric Point: 4.9467

>NTDB_id=303312 ETT47_RS08435 WP_136099144.1 1703057..1705612(-) (hexA) [Streptococcus pyogenes strain emm123]
MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDVSTGEFCVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFDSPCVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRNGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTNSNLSLVPEHFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKILATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADQVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIISAPSQV
ESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL

Nucleotide

• Length: 2556 bp

>NTDB_id=303312 ETT47_RS08435 WP_136099144.1 1703057..1705612(-) (hexA) [Streptococcus pyogenes strain emm123]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTACGAGGACGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCTATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTGTTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTATCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCGAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTACTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGCCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCA
TTGGTTCACTATGAGATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTTTAGATTTGGTAGAAAATGCTAG
GACTAATAAAAAACATGGAAGTCTCTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACCGATTTAAGCAATAGTTTAAAAGGTGTTTACGACATCGAACGCTTATCTAGTCGCGTGTCTTTTGGCAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCTCAAGTGCCTTATATCAAAGCTATCTTAGAGTCTTTTGACA
GTCCTTGTGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGAAGTATTATCCGCAATGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTAAT
GCGAGAGGGGACAGGCTGGATTGCGGATATTGAGGCCAAAGAGCGTCAAGCAAGTGGCATTAATAACCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTTCACGTTACGAATTCAAATCTTAGCTTAGTTCCCGAGCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAGCGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAATTTTGGCAACGGTAGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATCCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCGGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGACCAGGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGTACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGACTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTTGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATATCAGCCCCTTCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGAAGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAACATGACCCCGCTTCAAGCAATGACAACCCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain III (MutS_III) (256-546)

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain I (MutS_I) (8-118)

• MutS domain V (MutS_V) (599-785)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	71.68	100	0.717
mutS	Pseudomonas stutzeri strain ATCC 17587	37.31	100	0.375