Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexA   Type   Machinery gene
Locus tag   ETT56_RS09365 Genome accession   NZ_CP035443
Coordinates   1824480..1827035 (-) Length   851 a.a.
NCBI ID   WP_023610769.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm58     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1819480..1832035
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT56_RS09320 (ETT56_09310) - 1819716..1819982 (+) 267 WP_063632861.1 hypothetical protein -
  ETT56_RS09325 (ETT56_09315) - 1819989..1820147 (+) 159 WP_011529115.1 DUF2292 domain-containing protein -
  ETT56_RS09330 (ETT56_09320) - 1820248..1820850 (+) 603 WP_063632859.1 hypothetical protein -
  ETT56_RS09335 (ETT56_09325) - 1820840..1821169 (+) 330 WP_227876756.1 hydrolase -
  ETT56_RS09340 (ETT56_09330) - 1821445..1821711 (+) 267 WP_223824853.1 hypothetical protein -
  ETT56_RS09345 (ETT56_09335) - 1821817..1822230 (+) 414 WP_012560493.1 DUF1492 domain-containing protein -
  ETT56_RS09350 (ETT56_09340) - 1822305..1822505 (+) 201 WP_011529120.1 hypothetical protein -
  ETT56_RS09355 (ETT56_09345) - 1822557..1822766 (+) 210 Protein_1755 sigma factor-like helix-turn-helix DNA-binding protein -
  ETT56_RS09360 (ETT56_09350) - 1822741..1823124 (+) 384 WP_063632854.1 ArpU family phage packaging/lysis transcriptional regulator -
  ETT56_RS09770 - 1823323..1824084 (+) 762 WP_063632853.1 hypothetical protein -
  ETT56_RS09365 (ETT56_09355) hexA 1824480..1827035 (-) 2556 WP_023610769.1 DNA mismatch repair protein MutS Machinery gene
  ETT56_RS09935 (ETT56_09360) - 1827022..1827228 (-) 207 WP_011889237.1 YlbF family regulator -
  ETT56_RS09375 (ETT56_09365) argR 1827371..1827808 (-) 438 WP_023610766.1 arginine repressor -
  ETT56_RS09380 (ETT56_09370) argS 1828099..1829790 (+) 1692 WP_023610730.1 arginine--tRNA ligase -
  ETT56_RS09385 (ETT56_09375) - 1829878..1830186 (+) 309 WP_002991370.1 bacteriocin immunity protein -
  ETT56_RS09390 (ETT56_09380) - 1830213..1831085 (-) 873 WP_002982164.1 YitT family protein -
  ETT56_RS09395 (ETT56_09385) - 1831128..1832006 (-) 879 WP_023610708.1 YitT family protein -

Sequence

Protein


Download         Length: 851 a.a.        Molecular weight: 95477.99 Da        Isoelectric Point: 5.0199

>NTDB_id=302459 ETT56_RS09365 WP_023610769.1 1824480..1827035(-) (hexA) [Streptococcus pyogenes strain emm58]
MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDVSTGEFYVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFNSPCVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRTGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTTSNLSLVPEHFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKTLATVDVLQSLAVIAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIISVPSQV
ESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL

Nucleotide


Download         Length: 2556 bp        

>NTDB_id=302459 ETT56_RS09365 WP_023610769.1 1824480..1827035(-) (hexA) [Streptococcus pyogenes strain emm58]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTATGATGATGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCCATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTGTTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTATCTACAGGTGAATTTTACGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGCCAATTGACAA
CGGTAGAACTCACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCC
TTGGTTCATTATGAGATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTTTAGATTTGGTAGAAAATGCTAG
GACTAATAAAAAACATGGAAGTCTGTATTGGCTTTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACCGATTTAAGCAATAGTTTAAAAGGTGTTTACGACATCGAACGCTTATCTAGTCGCGTGTCTTTTGGCAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCCCAAGTGCCTTATATCAAAGCTATCTTAGAGTCTTTTAACA
GTCCTTGTGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGCAGTATTATTCGTACTGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTGAT
GCGAGAAGGAACAGGCTGGATTGCGGATATTGAGGCCAAAGAGCGTCAAGCAAGCGGCATTAATAATCTAAAAATTGATT
ACAATAAAAAAGATGGATATTATTTCCACGTTACGACTTCAAATCTTAGCTTAGTGCCTGAGCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAACGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAACTTTGGCAACGGTGGATGTTTTGCAAAGTTTAGCAGTCATTGCTGAAACCAATCATTATATCCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCGGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGACCATGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGTACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGACTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTGGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATATCAGTCCCTTCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGAAGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAACATGACCCCGCTTCAAGCAATGACAACCCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

MutS domain I (MutS_I)

(8-118)

MutS family domain IV (MutS_IV)

(415-506)

MutS domain II (MutS_II)

(126-239)

MutS domain V (MutS_V)

(599-785)

MutS domain III (MutS_III)

(256-546)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexA Streptococcus pneumoniae R6

71.328

100

0.713
  mutS Pseudomonas stutzeri strain ATCC 17587

37.5

100

0.377