Detailed information NTG0302409

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: DTA40_RS01650
• Genome accession: NZ_CP030928
• Coordinates: 299322..300839 (+)
• Length: 505 a.a.
• NCBI ID: WP_002949640.1
• Uniprot ID: A0A060BQ50
• Organism: Streptococcus thermophilus strain CS18
• Function: repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 294322..305839

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DTA40_RS09800 (DTA40_01635)	-	294602..294772 (+)	171	Protein_269	ascorbate 6-phosphate lactonase	-
DTA40_RS01625 (DTA40_01640)	-	294789..295460 (-)	672	WP_002946492.1	TrkA family potassium uptake protein	-
DTA40_RS01630 (DTA40_01645)	-	295500..296864 (-)	1365	WP_011680735.1	TrkH family potassium uptake protein	-
DTA40_RS01635 (DTA40_01650)	rsmG	296934..297647 (-)	714	WP_002946490.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
DTA40_RS01640 (DTA40_01655)	-	297944..298480 (+)	537	WP_014607968.1	DUF177 domain-containing protein	-
DTA40_RS01645 (DTA40_01660)	covR	298636..299325 (+)	690	WP_002949638.1	response regulator transcription factor	Regulator
DTA40_RS01650 (DTA40_01665)	covS	299322..300839 (+)	1518	WP_002949640.1	HAMP domain-containing histidine kinase	Regulator
DTA40_RS01655 (DTA40_01670)	nrdR	300961..301440 (+)	480	WP_011680738.1	transcriptional regulator NrdR	-
DTA40_RS01660 (DTA40_01675)	-	301437..302612 (+)	1176	WP_011680739.1	DnaD domain protein	-
DTA40_RS01665 (DTA40_01680)	dnaI	302616..303518 (+)	903	WP_014607971.1	primosomal protein DnaI	-
DTA40_RS01670 (DTA40_01685)	der	303624..304934 (+)	1311	WP_014607972.1	ribosome biogenesis GTPase Der	-
DTA40_RS10245	-	304998..305657 (+)	660	Protein_280	HI_0552 family protein	-

Sequence

Protein

• Length: 505 a.a.
• Molecular weight: 57536.93 Da
• Isoelectric Point: 5.2689

>NTDB_id=302409 DTA40_RS01650 WP_002949640.1 299322..300839(+) (covS) [Streptococcus thermophilus strain CS18]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide

• Length: 1518 bp

>NTDB_id=302409 DTA40_RS01650 WP_002949640.1 299322..300839(+) (covS) [Streptococcus thermophilus strain CS18]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (384-494)

• ArlS sensor domain (ArlS_N) (39-187)

• His Kinase A (phospho-acceptor) domain (HisKA) (270-329)

• HAMP domain (HAMP) (213-265)

3D structure

• AlphaFold DB: A0A060BQ50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Streptococcus salivarius strain HSISS4	94.622	99.406	0.941