Detailed information NTG0301792

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: ETT63_RS08870
• Genome accession: NZ_CP035436
• Coordinates: 1741795..1744350 (-)
• Length: 851 a.a.
• NCBI ID: WP_136267848.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm89.14
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1736795..1749350

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT63_RS08835 (ETT63_08830)	-	1738011..1738184 (+)	174	WP_003045773.1	hypothetical protein	-
ETT63_RS09260	-	1738190..1738363 (+)	174	WP_164972313.1	hypothetical protein	-
ETT63_RS08840 (ETT63_08835)	-	1738365..1738874 (+)	510	WP_109828907.1	hypothetical protein	-
ETT63_RS08845 (ETT63_08840)	-	1738949..1739437 (+)	489	WP_136267846.1	hypothetical protein	-
ETT63_RS08855 (ETT63_08850)	-	1739840..1740202 (+)	363	WP_003058730.1	DUF1492 domain-containing protein	-
ETT63_RS08860 (ETT63_08855)	-	1740177..1740560 (+)	384	WP_023612665.1	ArpU family phage packaging/lysis transcriptional regulator	-
ETT63_RS08865 (ETT63_08860)	-	1740765..1741397 (+)	633	WP_021775534.1	hypothetical protein	-
ETT63_RS08870 (ETT63_08865)	hexA	1741795..1744350 (-)	2556	WP_136267848.1	DNA mismatch repair protein MutS	Machinery gene
ETT63_RS09550 (ETT63_08870)	-	1744337..1744543 (-)	207	WP_032465308.1	YlbF family regulator	-
ETT63_RS08880 (ETT63_08875)	argR	1744686..1745123 (-)	438	WP_002982171.1	arginine repressor	-
ETT63_RS08885 (ETT63_08880)	argS	1745414..1747105 (+)	1692	WP_136267849.1	arginine--tRNA ligase	-
ETT63_RS08890 (ETT63_08885)	-	1747193..1747501 (+)	309	WP_002991370.1	bacteriocin immunity protein	-
ETT63_RS08895 (ETT63_08890)	-	1747528..1748400 (-)	873	WP_002982164.1	YitT family protein	-
ETT63_RS08900 (ETT63_08895)	-	1748443..1749321 (-)	879	WP_136095219.1	YitT family protein	-

Sequence

Protein

• Length: 851 a.a.
• Molecular weight: 95297.71 Da
• Isoelectric Point: 4.8184

>NTDB_id=301792 ETT63_RS08870 WP_136267848.1 1741795..1744350(-) (hexA) [Streptococcus pyogenes strain emm89.14]
MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDVSTGEFCVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFDSPCVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRNGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTTSNLSLVPEYFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKTLATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPEALLSRADEVLTRLEAQAQSAEIISVPSQV
ESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL

Nucleotide

• Length: 2556 bp

>NTDB_id=301792 ETT63_RS08870 WP_136267848.1 1741795..1744350(-) (hexA) [Streptococcus pyogenes strain emm89.14]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTACGAGGACGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCTATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTGTTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTATCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGCCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCC
TTGGTTCACTATGAGATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTTTAGATTTGGTAGAAAATGCTAG
GACTAATAAAAAACATGGAAGTCTCTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACCGATTTAAGCAATAGTTTAAAAGGTGTTTACGACATCGAACGCTTATCTAGTCGCGTGTCTTTTGGCAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCTCAAGTGCCTTATATCAAAGCTATCTTAGAGTCTTTTGACA
GTCCTTGTGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGAAGTATTATCCGCAATGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTGAT
GCGAGAAGGAACAGGCTGGATTGCGGATATTGAGGCCAAAGAGCGTCAAGCAAGCGGCATTAATAATCTAAAAATTGATT
ACAATAAAAAAGATGGATATTATTTCCACGTTACGACTTCAAATCTTAGCTTAGTGCCTGAGTATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAACGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAACTTTGGCAACGGTGGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATTCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCCGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGATCATGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGCACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGACTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTAGCAAAAATAGCAGGACTTCCTGAGGCCCTGC
TAAGCAGAGCAGATGAGGTGCTTACTCGTTTAGAAGCGCAAGCACAATCTGCTGAGATAATATCAGTCCCTTCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGAAGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAACATGACCCCGCTTCAAGCAATGACAACCCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain V (MutS_V) (599-785)

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	71.21	100	0.712
mutS	Pseudomonas stutzeri strain ATCC 17587	37.033	100	0.373