Detailed information NTG0301751

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: ETT63_RS03320
• Genome accession: NZ_CP035436
• Coordinates: 646851..649094 (+)
• Length: 747 a.a.
• NCBI ID: WP_002989173.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm89.14
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 641851..654094

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT63_RS03295 (ETT63_03295)	-	642082..644082 (+)	2001	WP_136273428.1	potassium transporter Kup	-
ETT63_RS03300 (ETT63_03300)	-	644106..644384 (-)	279	WP_002989164.1	GIY-YIG nuclease family protein	-
ETT63_RS03305 (ETT63_03305)	-	644374..645150 (-)	777	WP_010922438.1	tRNA1(Val) (adenine(37)-N6)-methyltransferase	-
ETT63_RS03310 (ETT63_03310)	-	645268..646008 (+)	741	WP_002989170.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
ETT63_RS03315 (ETT63_03315)	-	646208..646870 (+)	663	WP_002983967.1	ComEA family DNA-binding protein	-
ETT63_RS03320 (ETT63_03320)	comEC/celB	646851..649094 (+)	2244	WP_002989173.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ETT63_RS03325 (ETT63_03325)	holA	649165..650205 (+)	1041	WP_011888795.1	DNA polymerase III subunit delta	-
ETT63_RS03330 (ETT63_03330)	sodA	650302..650907 (+)	606	WP_023612500.1	superoxide dismutase SodA	-
ETT63_RS03335 (ETT63_03335)	-	651074..651301 (+)	228	WP_011054657.1	hypothetical protein	-
ETT63_RS03345 (ETT63_03345)	-	651286..652108 (+)	823	Protein_583	serine hydrolase	-
ETT63_RS03350 (ETT63_03350)	-	652222..653442 (-)	1221	WP_030126414.1	DUF3114 domain-containing protein	-

Sequence

Protein

• Length: 747 a.a.
• Molecular weight: 85501.38 Da
• Isoelectric Point: 9.6593

>NTDB_id=301751 ETT63_RS03320 WP_002989173.1 646851..649094(+) (comEC/celB) [Streptococcus pyogenes strain emm89.14]
MTFSWTKLVPLSKIQFAFLILVLFYQIHSPSWLTFLLSLSLICLLVKRLSKKEFLGVFAILSFCALFLLYQKQQLIQKLE
IQPVQITSVALVPDSIRINGDQLAVLGRHGKHSYQLFYRLKSQAEAQLFKKEHRWLVMHAKVTLEKAEEVRNFKGFNYQT
FLAYQGIYRIGKVEQIEQLEVISPESICDYLSSLRRRAIVHCQQHFPRPMSHYLTGLLFGYLDKSFGEMTDYYSQLGIIH
LFALSGMQVGFFLTCFRRVLLLLAVPLEWIKWIELPFACFYAALTGYSISVIRSLVQSQLRHLGIKGLDNLACTFLLVFL
WDAHFLMTVGGVLTFSYAFLLTVVTVEELSGAKRQLVQVLTISLGILPFLLFYFSSFNPMSMVLTGLLSYLFDLFILPLL
CLVFCLSPLVTVSICNHLFILLEKVIQFLGNTFNSSLVFGSPTSWHLLILVISFAIFYDYRQVRQRVITCGLVIALTLLS
VKYPLTNEVTFIDIGQGDSILVREWTGKNLLIDVGGRPFFSSKEHWRRGHHVANAQKTLIPYLKSRGIHTIDQLLVTHAD
TDHMGDIEVVAKAIRIKEILTSQGSLSHPSFVRRLRRLKCHVRVLAAGDQLPIMGSVLQVLYPWQLGDGKNNDSLVLYGR
LLNRTFLFTGDLEKEGENEIIKRYPQLRVDYLKAGHHGSNTSSSAAFLDHIQPKVAFISAGKNNRYQHPHRETLARLEDR
QITYYRTDTQGAIRLTGWTSWHLETVR

Nucleotide

• Length: 2244 bp

>NTDB_id=301751 ETT63_RS03320 WP_002989173.1 646851..649094(+) (comEC/celB) [Streptococcus pyogenes strain emm89.14]
ATGACATTTTCTTGGACTAAGCTAGTGCCCCTGTCAAAGATTCAATTTGCTTTTTTAATCTTGGTTCTCTTTTATCAAAT
CCATAGCCCTAGCTGGTTAACGTTTCTCCTTAGCCTTAGTTTGATTTGCTTACTTGTCAAGCGTTTGTCTAAAAAAGAAT
TTCTCGGTGTCTTTGCCATCCTTAGTTTCTGTGCTTTGTTTTTGCTGTATCAGAAACAGCAGTTGATTCAAAAACTGGAA
ATTCAGCCAGTACAAATAACCTCTGTAGCATTAGTTCCTGATAGTATTCGGATTAATGGTGATCAATTAGCTGTTCTTGG
ACGTCACGGGAAACATTCTTATCAGTTATTTTACCGTTTGAAAAGCCAAGCAGAAGCCCAATTGTTCAAGAAAGAGCACC
GTTGGTTAGTGATGCACGCAAAAGTGACATTGGAAAAAGCTGAGGAAGTTCGAAATTTTAAAGGCTTTAATTATCAGACT
TTTTTGGCTTATCAAGGAATTTACAGGATAGGGAAGGTAGAGCAAATAGAACAGCTTGAAGTGATTTCACCCGAGTCAAT
ATGTGACTATTTGTCCTCTTTAAGACGACGAGCCATTGTTCATTGCCAGCAGCATTTTCCAAGACCTATGTCTCACTACC
TGACGGGCCTCCTTTTTGGTTATTTAGATAAGTCGTTTGGTGAGATGACAGATTATTATAGTCAGTTGGGTATCATTCAT
CTCTTTGCTTTATCAGGGATGCAGGTTGGCTTCTTTCTCACTTGTTTTAGAAGGGTGTTGCTATTACTCGCAGTTCCTTT
GGAATGGATAAAATGGATAGAGCTTCCTTTTGCTTGCTTTTATGCCGCGTTGACAGGTTATAGTATTTCTGTTATTCGAA
GCCTCGTGCAGTCGCAGTTGCGTCATTTAGGAATAAAAGGATTAGACAATCTGGCTTGTACTTTTTTACTTGTCTTTTTA
TGGGATGCTCATTTCTTAATGACTGTTGGTGGCGTATTAACGTTTAGCTATGCTTTTTTGTTAACAGTGGTTACTGTTGA
AGAATTATCAGGAGCTAAAAGACAGTTGGTACAAGTCTTGACCATTTCCCTAGGAATATTACCATTTTTGCTCTTTTATT
TTTCTAGTTTTAACCCAATGTCAATGGTCTTAACAGGGCTCTTGTCTTATCTCTTTGACCTTTTTATTTTGCCCCTTCTT
TGTCTGGTTTTTTGTCTATCCCCTTTGGTGACTGTCTCAATATGTAACCATCTTTTTATTTTATTAGAAAAAGTCATTCA
ATTTCTCGGAAATACTTTCAATAGTTCCCTTGTTTTTGGAAGCCCGACCAGTTGGCACTTGCTTATCTTGGTGATTAGCT
TCGCTATTTTTTATGATTATCGGCAGGTGCGACAACGAGTTATCACTTGCGGCTTGGTTATAGCGTTGACGCTTTTGTCT
GTCAAATATCCTTTGACCAATGAAGTGACCTTTATCGACATTGGCCAGGGAGATAGTATTTTGGTGAGGGAGTGGACAGG
GAAAAATCTCTTAATAGATGTAGGTGGGCGCCCTTTCTTTTCTTCAAAAGAGCACTGGCGACGAGGACATCACGTAGCTA
ATGCTCAGAAAACCTTAATTCCTTACTTAAAAAGTAGAGGTATTCACACAATTGACCAACTATTAGTAACTCACGCAGAT
ACTGATCATATGGGGGATATCGAAGTGGTTGCCAAAGCTATTCGGATAAAGGAGATTTTGACTAGTCAAGGCAGTTTAAG
CCATCCAAGCTTTGTTAGGCGGCTAAGGCGTTTAAAATGTCACGTTAGGGTTTTAGCAGCTGGAGACCAGTTGCCTATTA
TGGGAAGTGTCTTACAGGTACTCTACCCTTGGCAGTTAGGGGACGGGAAAAATAACGATTCTTTGGTACTTTATGGCAGG
CTCTTAAATCGAACTTTTCTTTTCACAGGTGACTTGGAAAAAGAGGGGGAAAACGAGATCATAAAACGTTATCCTCAACT
AAGAGTAGATTATTTAAAAGCAGGTCACCATGGATCAAATACCTCTTCTAGTGCAGCTTTTTTAGACCATATTCAGCCTA
AAGTGGCCTTTATTTCTGCTGGAAAAAATAACCGTTATCAGCATCCTCACAGAGAAACCTTAGCCCGTTTGGAAGACAGA
CAAATTACTTATTACCGAACGGATACGCAAGGAGCTATTCGTTTGACTGGTTGGACAAGCTGGCATCTTGAAACGGTCCG
TTAG

Domains

Predicted by InterProScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (495-701)

• Competence protein (Competence) (217-462)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	46.319	100	0.463
comEC/celB	Streptococcus mitis NCTC 12261	46.113	99.866	0.461
comEC/celB	Streptococcus pneumoniae TIGR4	45.114	100	0.451
comEC/celB	Streptococcus pneumoniae Rx1	44.92	100	0.45
comEC/celB	Streptococcus pneumoniae D39	44.92	100	0.45
comEC/celB	Streptococcus pneumoniae R6	44.92	100	0.45
comEC	Lactococcus lactis subsp. cremoris KW2	40.671	99.732	0.406