Detailed information NTG0301235

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: ETT69_RS09380
• Genome accession: NZ_CP035430
• Coordinates: 1834601..1837156 (-)
• Length: 851 a.a.
• NCBI ID: WP_136019174.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm55
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1829601..1842156

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT69_RS09350 (ETT69_09340)	-	1830808..1830981 (+)	174	WP_068791229.1	DUF2758 domain-containing protein	-
ETT69_RS09795	-	1830987..1831160 (+)	174	WP_023610070.1	hypothetical protein	-
ETT69_RS09355 (ETT69_09345)	-	1831162..1831671 (+)	510	WP_136019171.1	hypothetical protein	-
ETT69_RS09360 (ETT69_09350)	-	1831745..1832233 (+)	489	WP_136019172.1	hypothetical protein	-
ETT69_RS09365 (ETT69_09355)	-	1832637..1832999 (+)	363	WP_002992136.1	DUF1492 domain-containing protein	-
ETT69_RS09370 (ETT69_09360)	-	1832974..1833357 (+)	384	WP_136019173.1	ArpU family phage packaging/lysis transcriptional regulator	-
ETT69_RS09375 (ETT69_09365)	-	1833565..1834203 (+)	639	WP_281726903.1	hypothetical protein	-
ETT69_RS09380 (ETT69_09370)	hexA	1834601..1837156 (-)	2556	WP_136019174.1	DNA mismatch repair protein MutS	Machinery gene
ETT69_RS10025 (ETT69_09375)	-	1837143..1837349 (-)	207	WP_136019175.1	hypothetical protein	-
ETT69_RS09390 (ETT69_09380)	argR	1837492..1837929 (-)	438	WP_002982171.1	arginine repressor	-
ETT69_RS09395 (ETT69_09385)	argS	1838220..1839911 (+)	1692	WP_011055093.1	arginine--tRNA ligase	-
ETT69_RS09400 (ETT69_09390)	-	1839999..1840307 (+)	309	WP_002991370.1	bacteriocin immunity protein	-
ETT69_RS09405 (ETT69_09395)	-	1840334..1841206 (-)	873	WP_002982164.1	YitT family protein	-
ETT69_RS09410 (ETT69_09400)	-	1841249..1842127 (-)	879	WP_002991372.1	YitT family protein	-

Sequence

Protein

• Length: 851 a.a.
• Molecular weight: 95496.99 Da
• Isoelectric Point: 4.9837

>NTDB_id=301235 ETT69_RS09380 WP_136019174.1 1834601..1837156(-) (hexA) [Streptococcus pyogenes strain emm55]
MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDVSTGEFCVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFDSPCVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRNGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTNSNLSLVPEHFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKMAKTLATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIISVPSQV
ESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPFQAMTTLYELKKLL

Nucleotide

• Length: 2556 bp

>NTDB_id=301235 ETT69_RS09380 WP_136019174.1 1834601..1837156(-) (hexA) [Streptococcus pyogenes strain emm55]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGGGACTTTTATGAATTATTTTACGAGGACGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCTATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTGTTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTATCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGCCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCA
TTGGTTCACTATGAGATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTTTAGATTTGGTAGAAAATGCTAG
GACTAATAAAAAACATGGAAGTCTCTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACCGATTTAAGCAATAGTTTAAAAGGTGTTTACGACATCGAACGCTTATCTAGTCGCGTGTCTTTTGGCAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCCCAAGTGCCTTATATCAAAGCTATCTTAGAGTCTTTTGACA
GTCCTTGTGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGAAGTATTATCCGCAATGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTAAT
GCGAGAGGGGACAGGCTGGATTGCGGATATTGAGGCCAAAGAGCGTCAAGCAAGTGGCATTAATAACCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTTCACGTTACGAATTCAAATCTTAGCTTAGTTCCCGAGCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAGCGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAAATGGCTA
AAACTTTGGCAACGGTGGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATTCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCCGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACTAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGATCATGTTGATTTGCCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGTACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGACTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTGGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATATCAGTCCCTTCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGAAGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAACATGACCCCGTTTCAAGCAATGACAACTCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

• MutS domain V (MutS_V) (599-785)

• MutS family domain IV (MutS_IV) (415-506)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	71.328	100	0.713
mutS	Pseudomonas stutzeri strain ATCC 17587	37.266	100	0.375