Detailed information NTG0300883

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: ETT72_RS02490
• Genome accession: NZ_CP035427
• Coordinates: 446363..448516 (-)
• Length: 717 a.a.
• NCBI ID: WP_032464223.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm74
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 441363..453516

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT72_RS02470 (ETT72_02470)	comE/blpR	442556..443305 (+)	750	WP_002992578.1	response regulator transcription factor	Regulator
ETT72_RS02475 (ETT72_02475)	-	443306..444640 (+)	1335	WP_032464222.1	sensor histidine kinase	-
ETT72_RS02480 (ETT72_02480)	-	444788..444913 (-)	126	WP_094189117.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
ETT72_RS02485 (ETT72_02485)	-	444988..446352 (-)	1365	WP_063629144.1	bacteriocin secretion accessory protein	-
ETT72_RS02490 (ETT72_02490)	comA/nlmT	446363..448516 (-)	2154	WP_032464223.1	peptide cleavage/export ABC transporter	Regulator
ETT72_RS02495 (ETT72_02495)	-	448799..449026 (+)	228	WP_002992018.1	Blp family class II bacteriocin	-
ETT72_RS02500 (ETT72_02500)	-	449039..449239 (+)	201	WP_002990771.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ETT72_RS02520 (ETT72_02520)	-	450252..450653 (+)	402	WP_023605036.1	hypothetical protein	-
ETT72_RS02525 (ETT72_02525)	-	450904..451974 (+)	1071	WP_110410759.1	hypothetical protein	-
ETT72_RS02530 (ETT72_02530)	-	452067..452465 (+)	399	WP_032464238.1	hypothetical protein	-
ETT72_RS02535 (ETT72_02535)	stcA	452813..453082 (-)	270	WP_023605037.1	quorum-sensing system protein StcA	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80558.55 Da
• Isoelectric Point: 7.1729

>NTDB_id=300883 ETT72_RS02490 WP_032464223.1 446363..448516(-) (comA/nlmT) [Streptococcus pyogenes strain emm74]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILKQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS

Nucleotide

• Length: 2154 bp

>NTDB_id=300883 ETT72_RS02490 WP_032464223.1 446363..448516(-) (comA/nlmT) [Streptococcus pyogenes strain emm74]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCAAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAGCTTCCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATCTC
ACGTTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTTCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGCTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCCTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAGTTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA

Domains

Predicted by InterProScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• ABC transporter (ABC_tran) (500-649)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.727	99.721	0.725
comA	Streptococcus mitis NCTC 12261	67.507	99.582	0.672
comA	Streptococcus mitis SK321	67.087	99.582	0.668
comA	Streptococcus pneumoniae Rx1	67.087	99.582	0.668
comA	Streptococcus pneumoniae D39	67.087	99.582	0.668
comA	Streptococcus pneumoniae R6	67.087	99.582	0.668
comA	Streptococcus pneumoniae TIGR4	66.807	99.582	0.665
comA	Streptococcus gordonii str. Challis substr. CH1	65.877	100	0.66