Detailed information NTG0300821

Bioinformatically predicted

Overview

• Name: ccrB
• Type: Machinery gene
• Locus tag: CSC59_RS00460
• Genome accession: NZ_CP030326
• Coordinates: 56506..58134 (-)
• Length: 542 a.a.
• NCBI ID: WP_001186601.1
• Uniprot ID: -
• Organism: Staphylococcus aureus strain AR_474
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	38178..59505	56506..58134	within	0

Gene organization within MGE regions

Location: 38178..59505

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSC59_RS00345 (CSC59_2607)	mecA	38178..40187 (-)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
CSC59_RS00350 (CSC59_2608)	mecR1	40284..42041 (+)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
CSC59_RS00355 (CSC59_2609)	mecI	42041..42412 (+)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
CSC59_RS00360	psm-mec	42497..42565 (-)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
CSC59_RS00365 (CSC59_2610)	-	42899..44029 (+)	1131	WP_010922808.1	ROK family transcriptional regulator	-
CSC59_RS00375 (CSC59_2612)	cstB	44143..45477 (-)	1335	Protein_34	persulfide dioxygenase-sulfurtransferase CstB	-
CSC59_RS00380 (CSC59_2613)	-	45510..46574 (-)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
CSC59_RS00385 (CSC59_2614)	cstR	46710..46970 (+)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
CSC59_RS00390 (CSC59_2615)	-	46970..47608 (+)	639	Protein_37	sulfite exporter TauE/SafE family protein	-
CSC59_RS00400 (CSC59_2616)	-	47953..48615 (-)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
CSC59_RS00415 (CSC59_2617)	erm(A)	49111..49842 (+)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
CSC59_RS00420 (CSC59_2618)	-	49968..50750 (-)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
CSC59_RS00425 (CSC59_2619)	-	50901..51278 (-)	378	WP_000361059.1	DUF6262 family protein	-
CSC59_RS00430 (CSC59_2620)	-	51285..53177 (-)	1893	WP_001557544.1	site-specific integrase	-
CSC59_RS00435 (CSC59_2621)	-	53174..54259 (-)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
CSC59_RS00440 (CSC59_2622)	-	54378..54695 (-)	318	WP_000659050.1	JAB domain-containing protein	-
CSC59_RS00445 (CSC59_2623)	-	54716..55222 (-)	507	WP_001092169.1	DUF1643 domain-containing protein	-
CSC59_RS00450 (CSC59_2624)	-	55240..55551 (-)	312	WP_000700853.1	DUF960 family protein	-
CSC59_RS00455 (CSC59_2625)	-	55638..55988 (-)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
CSC59_RS00460 (CSC59_2626)	ccrB	56506..58134 (-)	1629	WP_001186601.1	recombinase family protein	Machinery gene
CSC59_RS00465 (CSC59_2627)	ccrA	58156..59505 (-)	1350	WP_000815646.1	recombinase family protein	Machinery gene

Sequence

Protein

• Length: 542 a.a.
• Molecular weight: 62678.86 Da
• Isoelectric Point: 9.8600

>NTDB_id=300821 CSC59_RS00460 WP_001186601.1 56506..58134(-) (ccrB) [Staphylococcus aureus strain AR_474]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEINTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI

Nucleotide

• Length: 1629 bp

>NTDB_id=300821 CSC59_RS00460 WP_001186601.1 56506..58134(-) (ccrB) [Staphylococcus aureus strain AR_474]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAATCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG

Domains

Predicted by InterproScan.

• Resolvase, N terminal domain (Resolvase) (11-156)

• Ogr/Delta-like zinc finger (Ogr_Delta) (301-356)

• Recombinase (Recombinase) (180-280)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrB	Staphylococcus aureus N315	99.815	100	0.998