Detailed information NTG0300786

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CSC60_RS06560
• Genome accession: NZ_CP030323
• Coordinates: 1308693..1309736 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AR_475
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1303693..1314736

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSC60_RS06530	-	1304119..1304229 (+)	111	WP_001790257.1	hypothetical protein	-
CSC60_RS06535 (CSC60_1203)	-	1304258..1304671 (+)	414	WP_025174552.1	hypothetical protein	-
CSC60_RS06540 (CSC60_1204)	-	1305104..1306090 (-)	987	WP_000999708.1	aromatic acid exporter family protein	-
CSC60_RS06545 (CSC60_1205)	map	1306619..1307377 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CSC60_RS06550 (CSC60_1206)	-	1307594..1307980 (+)	387	WP_001110179.1	hypothetical protein	-
CSC60_RS06555 (CSC60_1207)	liaF	1307995..1308696 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CSC60_RS06560 (CSC60_1208)	vraS	1308693..1309736 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CSC60_RS06565 (CSC60_1209)	vraR	1309726..1310355 (+)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
CSC60_RS06570 (CSC60_1210)	-	1310468..1311685 (-)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
CSC60_RS06575 (CSC60_1211)	-	1311963..1312238 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
CSC60_RS06580 (CSC60_1212)	-	1312245..1312709 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CSC60_RS06585 (CSC60_1213)	-	1312856..1313056 (+)	201	WP_000180460.1	DUF1128 family protein	-
CSC60_RS06590	-	1313059..1314314 (+)	1256	Protein_1249	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=300786 CSC60_RS06560 WP_001017131.1 1308693..1309736(+) (vraS) [Staphylococcus aureus strain AR_475]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=300786 CSC60_RS06560 WP_001017131.1 1308693..1309736(+) (vraS) [Staphylococcus aureus strain AR_475]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1