Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   CSC60_RS02140 Genome accession   NZ_CP030323
Coordinates   445760..447109 (+) Length   449 a.a.
NCBI ID   WP_000815640.1    Uniprot ID   -
Organism   Staphylococcus aureus strain AR_475     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 438363..455524 445760..447109 within 0


Gene organization within MGE regions


Location: 438363..455524
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CSC60_RS02115 (CSC60_0392) - 438363..440234 (-) 1872 WP_000666921.1 zinc-ribbon domain-containing protein -
  CSC60_RS14455 (CSC60_0393) - 440536..440685 (-) 150 WP_190349608.1 hypothetical protein -
  CSC60_RS02120 (CSC60_0394) - 440685..442199 (-) 1515 WP_000627204.1 protein kinase -
  CSC60_RS02125 (CSC60_0395) - 442217..443284 (-) 1068 WP_001099283.1 hypothetical protein -
  CSC60_RS02130 (CSC60_0396) - 443440..443733 (+) 294 WP_000182688.1 single-stranded DNA-binding protein -
  CSC60_RS02135 (CSC60_0397) - 443733..445526 (+) 1794 WP_031928950.1 DUF927 domain-containing protein -
  CSC60_RS02140 (CSC60_0398) ccrA 445760..447109 (+) 1350 WP_000815640.1 recombinase family protein Machinery gene
  CSC60_RS02145 (CSC60_0399) ccrB 447131..448759 (+) 1629 WP_001186608.1 recombinase family protein Machinery gene
  CSC60_RS02150 - 449281..449631 (+) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  CSC60_RS02160 (CSC60_0401) - 449718..450029 (+) 312 WP_000700851.1 DUF960 family protein -
  CSC60_RS02165 (CSC60_0402) - 450044..450550 (+) 507 WP_001092189.1 DUF1643 domain-containing protein -
  CSC60_RS02170 (CSC60_0403) - 450602..452209 (+) 1608 Protein_414 IS1182 family transposase -
  CSC60_RS02175 (CSC60_0404) - 452200..452460 (-) 261 WP_001549961.1 type I restriction enzyme endonuclease domain-containing protein -
  CSC60_RS02180 (CSC60_0405) - 452432..453418 (-) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  CSC60_RS02185 (CSC60_0406) mecA 453515..455524 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52663.34 Da        Isoelectric Point: 9.9639

>NTDB_id=300776 CSC60_RS02140 WP_000815640.1 445760..447109(+) (ccrA) [Staphylococcus aureus strain AR_475]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=300776 CSC60_RS02140 WP_000815640.1 445760..447109(+) (ccrA) [Staphylococcus aureus strain AR_475]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Recombinase (Recombinase)

(169-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

97.55

100

0.976
  ccrA Staphylococcus aureus COL

75.947

100

0.759

Multiple sequence alignment