Detailed information NTG0299641

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: C2G36_RS10805
• Genome accession: NZ_CP030138
• Coordinates: 2056950..2057993 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain M48
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2051950..2062993

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C2G36_RS10775 (C2G36_10780)	-	2052368..2053624 (-)	1257	WP_001795438.1	aminopeptidase	-
C2G36_RS10780 (C2G36_10785)	-	2053627..2053827 (-)	201	WP_000180461.1	DUF1128 family protein	-
C2G36_RS10785 (C2G36_10790)	-	2053974..2054438 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
C2G36_RS10790 (C2G36_10795)	-	2054445..2054720 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
C2G36_RS10795 (C2G36_10800)	-	2054998..2056215 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
C2G36_RS10800 (C2G36_10805)	vraR	2056331..2056960 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
C2G36_RS10805 (C2G36_10810)	vraS	2056950..2057993 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
C2G36_RS10810 (C2G36_10815)	liaF	2057990..2058691 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
C2G36_RS10815 (C2G36_10820)	-	2058706..2059092 (-)	387	WP_001110179.1	hypothetical protein	-
C2G36_RS10820 (C2G36_10825)	map	2059309..2060067 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
C2G36_RS10830 (C2G36_10835)	-	2060654..2061640 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
C2G36_RS10840 (C2G36_10845)	-	2062071..2062484 (-)	414	WP_001549145.1	hypothetical protein	-
C2G36_RS10845 (C2G36_10850)	-	2062513..2062623 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=299641 C2G36_RS10805 WP_001017131.1 2056950..2057993(-) (vraS) [Staphylococcus aureus strain M48]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=299641 C2G36_RS10805 WP_001017131.1 2056950..2057993(-) (vraS) [Staphylococcus aureus strain M48]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1