Detailed information NTG0299607

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: C2G36_RS00295
• Genome accession: NZ_CP030138
• Coordinates: 58163..59509 (-)
• Length: 448 a.a.
• NCBI ID: WP_000816499.1
• Uniprot ID: Q9R3W9
• Organism: Staphylococcus aureus strain M48
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	38684..59509	58163..59509	within	0

Gene organization within MGE regions

Location: 38684..59509

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C2G36_RS00175 (C2G36_00175)	mecA	38684..40693 (-)	2010	WP_078066067.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
C2G36_RS00180 (C2G36_00180)	mecR1	40790..42547 (+)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
C2G36_RS00185 (C2G36_00185)	mecI	42547..42918 (+)	372	Protein_31	mecA-type methicillin resistance repressor MecI	-
C2G36_RS00190 (C2G36_00190)	psm-mec	43003..43071 (-)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
C2G36_RS00195 (C2G36_00195)	-	43391..44371 (+)	981	WP_129367377.1	ROK family transcriptional regulator	-
C2G36_RS16350	cstB	44485..45426 (-)	942	Protein_34	persulfide dioxygenase-sulfurtransferase CstB	-
C2G36_RS00205 (C2G36_00210)	cstB	45433..45885 (-)	453	Protein_35	persulfide dioxygenase-sulfurtransferase CstB	-
C2G36_RS00210 (C2G36_00215)	-	45918..46982 (-)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
C2G36_RS00215 (C2G36_00220)	cstR	47118..47378 (+)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
C2G36_RS00220 (C2G36_00225)	-	47414..47956 (+)	543	Protein_38	sulfite exporter TauE/SafE family protein	-
C2G36_RS00230 (C2G36_00235)	-	48230..48847 (-)	618	WP_000562107.1	CadD family cadmium resistance transporter	-
C2G36_RS00235 (C2G36_00240)	-	48928..51342 (-)	2415	WP_000378485.1	cadmium-translocating P-type ATPase CadA	-
C2G36_RS00240 (C2G36_00245)	-	51335..51700 (-)	366	WP_000159127.1	metalloregulator ArsR/SmtB family transcription factor	-
C2G36_RS00245 (C2G36_00250)	-	51886..52094 (-)	209	Protein_42	hypothetical protein	-
C2G36_RS00255 (C2G36_00260)	-	52084..54038 (-)	1955	Protein_43	site-specific integrase	-
C2G36_RS00260 (C2G36_00265)	-	54233..54556 (-)	324	WP_000088091.1	JAB domain-containing protein	-
C2G36_RS00265 (C2G36_00270)	-	54549..54755 (-)	207	WP_001077283.1	hypothetical protein	-
C2G36_RS00270 (C2G36_00275)	-	54757..55278 (-)	522	WP_000836008.1	DUF1643 domain-containing protein	-
C2G36_RS00275 (C2G36_00280)	-	55297..55608 (-)	312	WP_000833212.1	DUF960 family protein	-
C2G36_RS00285 (C2G36_00290)	-	55693..56043 (-)	351	WP_000171449.1	SAUGI family uracil-DNA glycosylase inhibitor	-
C2G36_RS00290 (C2G36_00295)	ccrB	56514..58142 (-)	1629	WP_001186596.1	recombinase family protein	Machinery gene
C2G36_RS00295 (C2G36_00300)	ccrA	58163..59509 (-)	1347	WP_000816499.1	recombinase family protein	Machinery gene

Sequence

Protein

• Length: 448 a.a.
• Molecular weight: 52138.19 Da
• Isoelectric Point: 10.1760

>NTDB_id=299607 C2G36_RS00295 WP_000816499.1 58163..59509(-) (ccrA) [Staphylococcus aureus strain M48]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA

Nucleotide

• Length: 1347 bp

>NTDB_id=299607 C2G36_RS00295 WP_000816499.1 58163..59509(-) (ccrA) [Staphylococcus aureus strain M48]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (168-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-321)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9R3W9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus COL	78.174	100	0.783
ccrA	Staphylococcus aureus N315	72.383	100	0.725