Detailed information NTG0299567

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: C2G35_RS04515
• Genome accession: NZ_CP030137
• Coordinates: 824081..825124 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain M51
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 819081..830124

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C2G35_RS04475 (C2G35_04475)	-	819450..819560 (+)	111	WP_001790257.1	hypothetical protein	-
C2G35_RS04480 (C2G35_04480)	-	819589..820002 (+)	414	WP_001549145.1	hypothetical protein	-
C2G35_RS04490 (C2G35_04490)	-	820433..821419 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
C2G35_RS04500 (C2G35_04500)	map	822006..822764 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
C2G35_RS04505 (C2G35_04505)	-	822981..823368 (+)	388	Protein_841	hypothetical protein	-
C2G35_RS04510 (C2G35_04510)	liaF	823383..824084 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
C2G35_RS04515 (C2G35_04515)	vraS	824081..825124 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
C2G35_RS04520 (C2G35_04520)	vraR	825114..825743 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
C2G35_RS04525 (C2G35_04525)	-	825859..827076 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
C2G35_RS04530 (C2G35_04530)	-	827354..827629 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
C2G35_RS04535 (C2G35_04535)	-	827636..828100 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
C2G35_RS04540 (C2G35_04540)	-	828247..828447 (+)	201	WP_000180461.1	DUF1128 family protein	-
C2G35_RS04545 (C2G35_04545)	-	828450..829706 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=299567 C2G35_RS04515 WP_001017131.1 824081..825124(+) (vraS) [Staphylococcus aureus strain M51]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=299567 C2G35_RS04515 WP_001017131.1 824081..825124(+) (vraS) [Staphylococcus aureus strain M51]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1