Detailed information NTG0298502

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: DK877_RS09835
• Genome accession: NZ_CP030023
• Coordinates: 1979375..1981828 (-)
• Length: 817 a.a.
• NCBI ID: WP_009910884.1
• Uniprot ID: A0A7Y6RRF0
• Organism: Streptococcus suis strain ISU2414
• Function: degradation of ComW (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1977661..2000759	1979375..1981828	within	0

Gene organization within MGE regions

Location: 1977661..2000759

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DK877_RS09825 (DK877_10135)	dusB	1977661..1978665 (+)	1005	WP_009910879.1	tRNA dihydrouridine synthase DusB	-
DK877_RS09830 (DK877_10140)	-	1978766..1979257 (-)	492	WP_009910880.1	adenylyltransferase/cytidyltransferase family protein	-
DK877_RS09835 (DK877_10145)	clpC	1979375..1981828 (-)	2454	WP_009910884.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
DK877_RS09840 (DK877_10150)	-	1981832..1982284 (-)	453	WP_013730590.1	CtsR family transcriptional regulator	-
DK877_RS09845 (DK877_10155)	-	1982452..1982811 (+)	360	WP_013730591.1	bacteriocin transporter	-
DK877_RS09850 (DK877_10160)	-	1982883..1984751 (-)	1869	WP_013730592.1	Ig-like domain-containing protein	-
DK877_RS09855 (DK877_10165)	-	1985296..1986498 (+)	1203	WP_009909264.1	IS110-like element ISSsu7 family transposase	-
DK877_RS09860 (DK877_10170)	tsf	1986729..1987769 (-)	1041	WP_002937816.1	translation elongation factor Ts	-
DK877_RS09865 (DK877_10175)	rpsB	1988022..1988798 (-)	777	WP_012775356.1	30S ribosomal protein S2	-
DK877_RS09870 (DK877_10180)	-	1989145..1989657 (-)	513	WP_013730593.1	adenylate kinase	-
DK877_RS09880 (DK877_10190)	-	1990311..1995389 (-)	5079	WP_024409253.1	S8 family serine peptidase	-
DK877_RS09885 (DK877_10195)	nusG	1995533..1996072 (-)	540	WP_002940254.1	transcription termination/antitermination protein NusG	-
DK877_RS09890 (DK877_10200)	secE	1996182..1996358 (-)	177	WP_002940255.1	preprotein translocase subunit SecE	-
DK877_RS09895 (DK877_10205)	rpmG	1996368..1996520 (-)	153	WP_002940258.1	50S ribosomal protein L33	-
DK877_RS09900 (DK877_10210)	pbp2a	1996554..1998767 (-)	2214	WP_009910891.1	penicillin-binding protein PBP2A	-
DK877_RS09905 (DK877_10215)	-	1998920..1999888 (+)	969	WP_013730595.1	NAD(P)/FAD-dependent oxidoreductase	-
DK877_RS09910 (DK877_10220)	-	1999890..2000759 (+)	870	WP_013730596.1	RluA family pseudouridine synthase	-

Sequence

Protein

• Length: 817 a.a.
• Molecular weight: 90461.93 Da
• Isoelectric Point: 6.0456

>NTDB_id=298502 DK877_RS09835 WP_009910884.1 1979375..1981828(-) (clpC) [Streptococcus suis strain ISU2414]
MKISTGLQRVFEDAQLVAQRYACDYLETWHVLLSFVINHDTVAGAVLAEYPISISDYEHATFVVTDKVYREELDSFRILP
SSKRLDETASFAKKIAEVVKAKELGTEHLFMAMLLDKRSTASQILDKVGFCFEDSDDKFRFLDLRKNLEARAGFTKEDLK
AIRSVMKGGKAKPTNMGQMMGMPPAPQSGGLEDYTRDLTALAREGKIEPVIGRDAEIARMIQILSRKTKNNPVLVGDAGV
GKTALALGLAQRVAAGDVPVSLAKMRVLELDLMNVIAGTRFRGDFEERMNNIINDIEEDGQVILFIDELHTIMGSGSGID
STLDAANILKPALARGTLRTVGATTQTEYQKHIEKDAALVRRFAKVTIEEPTVEDSIAILTGLKGTFEKYHRVRIGQAAV
ETAVTYAKRYLTSKNLPDSAIDLLDEASATVQNRVKGQGEETGLTSIDKALMDKKYKTVSKLLIETKEDAEASQNYDLEV
TEEDVLETLSRLSGIPVAKLSQSDTKKYLNLEAELHKRVIGQEEAISAVSRAIRRNQSGIRTGRRPIGSFMFLGPTGVGK
TELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLL
QVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGALDLSKDHKEVEKRIFEELKKAYRPEFINRIDEKVVF
HSLTETHMQDVVKVMIKPLLAVTAEKGITLKLQPSALKLLAKQGYDPEMGARPLRRLLQTKLEDPLAEMLLRGDLTTSST
LKVGVKGEELKFDVVKG

Nucleotide

• Length: 2454 bp

>NTDB_id=298502 DK877_RS09835 WP_009910884.1 1979375..1981828(-) (clpC) [Streptococcus suis strain ISU2414]
ATGAAAATTTCAACTGGTTTACAGCGGGTTTTTGAAGATGCCCAGTTAGTGGCTCAACGTTATGCCTGTGATTACTTGGA
AACCTGGCATGTTCTCTTGTCTTTCGTTATCAACCATGATACAGTCGCTGGCGCTGTTTTGGCAGAATATCCTATTTCAA
TTTCTGACTATGAACATGCAACTTTTGTTGTGACCGACAAGGTCTATCGTGAAGAGTTGGATAGTTTTCGTATTTTACCA
TCTTCTAAACGTTTGGATGAAACGGCTAGTTTTGCCAAGAAAATTGCAGAAGTCGTCAAGGCTAAGGAGCTGGGAACGGA
ACATTTGTTTATGGCTATGTTGTTGGACAAGCGGTCAACAGCTAGTCAGATTTTGGACAAGGTAGGTTTTTGTTTTGAAG
ACTCAGATGATAAGTTTCGTTTCTTGGATTTGCGTAAAAACTTGGAGGCACGTGCGGGATTTACCAAAGAGGACCTTAAA
GCTATCCGCAGTGTGATGAAGGGTGGCAAAGCCAAACCTACTAATATGGGACAGATGATGGGAATGCCCCCAGCACCTCA
AAGTGGTGGATTAGAAGACTACACTCGTGATTTGACAGCTTTGGCGCGTGAAGGGAAGATTGAACCTGTCATCGGTCGAG
ACGCTGAGATTGCACGGATGATCCAAATTCTATCACGTAAAACCAAGAATAACCCAGTTCTAGTTGGTGATGCTGGTGTC
GGAAAAACTGCGCTTGCTTTGGGTCTTGCTCAACGTGTTGCTGCAGGTGATGTCCCTGTCAGCTTGGCTAAGATGCGGGT
TTTGGAACTTGACTTGATGAACGTTATCGCTGGAACTCGTTTCCGTGGTGATTTCGAAGAGCGGATGAATAATATCATCA
ACGACATCGAGGAAGATGGTCAGGTCATCCTTTTCATCGATGAGTTGCATACCATTATGGGTTCTGGCTCAGGGATTGAT
TCGACCTTGGATGCAGCCAATATCCTCAAACCAGCTCTTGCTCGGGGCACCCTCCGTACGGTCGGAGCGACGACTCAGAC
AGAGTACCAAAAGCATATTGAGAAAGACGCAGCCCTGGTTCGTCGTTTTGCCAAAGTGACCATTGAAGAGCCGACAGTGG
AAGATAGCATTGCCATTTTGACTGGTTTAAAAGGTACTTTTGAAAAATACCACAGGGTCCGTATTGGACAAGCAGCTGTA
GAGACTGCTGTGACCTACGCTAAGCGGTATTTGACCAGTAAAAACCTGCCAGATTCTGCCATTGACTTGCTGGATGAAGC
CAGTGCAACGGTACAAAATCGAGTGAAAGGGCAGGGTGAGGAAACAGGACTGACGAGCATAGACAAGGCCTTGATGGATA
AAAAATATAAGACTGTCAGCAAGCTTTTGATTGAAACGAAAGAAGATGCCGAGGCTAGTCAAAACTATGACCTTGAAGTA
ACAGAAGAAGATGTTTTAGAAACACTTAGCCGCTTGTCAGGTATCCCAGTAGCCAAGCTTAGCCAATCAGATACTAAGAA
GTATCTGAATCTGGAAGCAGAATTGCACAAGCGTGTGATTGGGCAGGAAGAAGCTATTTCTGCAGTTAGCAGAGCTATTC
GCCGTAATCAGTCAGGGATTCGTACAGGTCGCAGACCGATTGGTTCCTTTATGTTCTTGGGACCAACTGGTGTCGGTAAG
ACAGAGCTTGCTAAAGCCTTGGCAGAGGTTCTCTTTGATGATGAATCTGCTCTTATCCGTTTTGATATGTCCGAGTATAT
GGAGAAATTTGCGGCCAGCCGTCTCAATGGAGCGCCTCCAGGTTACGTGGGCTATGAAGAAGGTGGCGAATTGACAGAAA
AAGTTCGTAACAAACCTTATTCTGTTCTTCTTTTTGATGAGGTTGAAAAGGCTCATCCAGATATTTTCAATGTTCTCTTG
CAGGTCTTGGATGATGGTGTTCTGACGGACAGTAAGGGACGTAAGGTTGATTTCTCAAATACTATTATTATCATGACGTC
AAACCTTGGAGCAACAGCTCTTCGTGATGATAAGACAGTTGGTTTTGGTGCCCTTGATTTATCTAAGGACCACAAGGAAG
TGGAGAAACGCATTTTTGAGGAATTGAAAAAAGCCTATCGTCCAGAATTTATCAACCGTATTGACGAGAAAGTTGTCTTC
CATAGCCTAACGGAAACTCATATGCAGGATGTTGTCAAGGTCATGATTAAACCTTTGTTGGCTGTAACAGCTGAGAAAGG
AATTACTCTTAAACTGCAACCGTCAGCCCTTAAGTTATTGGCTAAACAAGGTTATGACCCAGAAATGGGGGCTCGTCCGC
TACGTAGGCTCTTACAAACCAAATTGGAAGATCCGTTGGCAGAAATGTTACTCCGTGGTGACTTGACTACTAGTTCGACC
TTGAAGGTTGGGGTCAAGGGTGAAGAGCTCAAGTTTGATGTGGTAAAGGGATAA

Domains

Predicted by InterproScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (233-365)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (723-802)

• AAA domain (Cdc48 subfamily) (AAA_2) (545-716)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (102-129)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (14-56)

• AAA lid domain (AAA_lid_9) (372-455)

3D structure

• AlphaFold DB: A0A7Y6RRF0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus pneumoniae TIGR4	71.902	99.755	0.717
clpC	Streptococcus pneumoniae Rx1	71.902	99.755	0.717
clpC	Streptococcus pneumoniae D39	71.902	99.755	0.717
clpC	Streptococcus mutans UA159	66.339	99.633	0.661
clpC	Streptococcus thermophilus LMD-9	64.14	100	0.652
clpC	Streptococcus thermophilus LMG 18311	64.14	100	0.652
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.982	100	0.501
clpC	Bacillus subtilis subsp. subtilis str. 168	43.349	100	0.447