Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   A7J09_RS10955 Genome accession   NZ_CP030015
Coordinates   2295738..2298191 (-) Length   817 a.a.
NCBI ID   WP_029175047.1    Uniprot ID   -
Organism   Streptococcus suis strain ISU2812     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2295128..2334124 2295738..2298191 within 0


Gene organization within MGE regions


Location: 2295128..2334124
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A7J09_RS10950 (A7J09_11185) - 2295128..2295619 (-) 492 WP_029175048.1 adenylyltransferase/cytidyltransferase family protein -
  A7J09_RS10955 (A7J09_11190) clpC 2295738..2298191 (-) 2454 WP_029175047.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  A7J09_RS10960 (A7J09_11195) - 2298195..2298653 (-) 459 WP_002937810.1 CtsR family transcriptional regulator -
  A7J09_RS10965 (A7J09_11200) - 2298923..2299261 (+) 339 WP_029178603.1 thioredoxin domain-containing protein -
  A7J09_RS10970 (A7J09_11205) tsf 2299428..2300468 (-) 1041 WP_024386113.1 translation elongation factor Ts -
  A7J09_RS10975 (A7J09_11210) rpsB 2300595..2301371 (-) 777 WP_024386112.1 30S ribosomal protein S2 -
  A7J09_RS10985 (A7J09_11220) - 2301903..2302307 (-) 405 WP_029178602.1 type II toxin-antitoxin system HicB family antitoxin -
  A7J09_RS10990 (A7J09_11225) - 2302368..2302553 (-) 186 WP_024376845.1 type II toxin-antitoxin system HicA family toxin -
  A7J09_RS10995 (A7J09_11230) - 2302794..2303513 (-) 720 WP_029178601.1 CHAP domain-containing protein -
  A7J09_RS11000 (A7J09_11235) - 2303510..2303848 (-) 339 WP_029178600.1 phage holin -
  A7J09_RS11005 (A7J09_11240) - 2303850..2304278 (-) 429 WP_029178599.1 hypothetical protein -
  A7J09_RS11010 (A7J09_11245) - 2304282..2304626 (-) 345 WP_029178598.1 hypothetical protein -
  A7J09_RS11015 (A7J09_11250) - 2304629..2304826 (-) 198 WP_029178597.1 hypothetical protein -
  A7J09_RS11020 (A7J09_11255) - 2304835..2310075 (-) 5241 WP_148124338.1 phage tail spike protein -
  A7J09_RS11025 (A7J09_11260) - 2310076..2310798 (-) 723 WP_029178504.1 phage tail protein -
  A7J09_RS11030 (A7J09_11265) - 2310801..2313554 (-) 2754 WP_029989045.1 hypothetical protein -
  A7J09_RS11035 (A7J09_11270) - 2313862..2314281 (-) 420 WP_029178503.1 hypothetical protein -
  A7J09_RS11040 (A7J09_11275) - 2314293..2314868 (-) 576 WP_029178502.1 major tail protein -
  A7J09_RS11045 (A7J09_11280) - 2314881..2315204 (-) 324 WP_027972590.1 hypothetical protein -
  A7J09_RS11050 (A7J09_11285) - 2315201..2315560 (-) 360 WP_029178501.1 HK97 gp10 family phage protein -
  A7J09_RS11055 (A7J09_11290) - 2315557..2315856 (-) 300 WP_029178500.1 phage head closure protein -
  A7J09_RS11060 (A7J09_11295) - 2315843..2316124 (-) 282 WP_029178499.1 hypothetical protein -
  A7J09_RS11065 - 2316127..2316624 (-) 498 WP_216358482.1 hypothetical protein -
  A7J09_RS11070 (A7J09_11305) - 2316637..2317806 (-) 1170 WP_029178357.1 phage major capsid protein -
  A7J09_RS11075 (A7J09_11310) - 2317803..2318381 (-) 579 WP_029178358.1 HK97 family phage prohead protease -
  A7J09_RS11080 (A7J09_11315) - 2318368..2319570 (-) 1203 WP_029178359.1 phage portal protein -
  A7J09_RS11085 (A7J09_11320) - 2319588..2319806 (-) 219 WP_029178360.1 hypothetical protein -
  A7J09_RS11090 (A7J09_11325) - 2319814..2321589 (-) 1776 WP_029178361.1 terminase large subunit -
  A7J09_RS11095 (A7J09_11330) - 2321582..2321971 (-) 390 WP_029178362.1 P27 family phage terminase small subunit -
  A7J09_RS11100 (A7J09_11335) - 2322082..2322414 (-) 333 WP_029752997.1 hypothetical protein -
  A7J09_RS11105 (A7J09_11340) - 2322541..2322720 (-) 180 WP_029752998.1 hypothetical protein -
  A7J09_RS11110 (A7J09_11345) - 2322895..2323437 (-) 543 WP_024390676.1 tyrosine-type recombinase/integrase -
  A7J09_RS11115 (A7J09_11350) - 2323629..2323955 (-) 327 WP_321537784.1 transcriptional regulator -
  A7J09_RS11120 - 2323846..2324235 (-) 390 WP_321537785.1 hypothetical protein -
  A7J09_RS11125 - 2324244..2324411 (-) 168 WP_162840673.1 hypothetical protein -
  A7J09_RS11130 (A7J09_11355) - 2324402..2324677 (-) 276 WP_029178364.1 hypothetical protein -
  A7J09_RS11135 (A7J09_11360) - 2324894..2325307 (-) 414 WP_029178365.1 hypothetical protein -
  A7J09_RS11140 (A7J09_11365) - 2325402..2325620 (-) 219 WP_029744327.1 hypothetical protein -
  A7J09_RS11145 (A7J09_11370) - 2325608..2326408 (-) 801 WP_029178366.1 phage replisome organizer N-terminal domain-containing protein -
  A7J09_RS11150 - 2326392..2326568 (-) 177 WP_153308684.1 hypothetical protein -
  A7J09_RS11155 (A7J09_11375) - 2326571..2326825 (-) 255 WP_029178367.1 hypothetical protein -
  A7J09_RS11160 (A7J09_11380) - 2326827..2327015 (-) 189 WP_029178368.1 hypothetical protein -
  A7J09_RS11165 (A7J09_11385) - 2327012..2327296 (-) 285 WP_029171141.1 hypothetical protein -
  A7J09_RS11170 (A7J09_11390) - 2327357..2328064 (-) 708 WP_029178369.1 ORF6C domain-containing protein -
  A7J09_RS11175 (A7J09_11395) - 2328118..2328549 (+) 432 WP_029178370.1 hypothetical protein -
  A7J09_RS11180 (A7J09_11400) - 2328829..2329026 (-) 198 WP_024412305.1 hypothetical protein -
  A7J09_RS11185 (A7J09_11405) - 2329031..2329243 (-) 213 WP_024381154.1 hypothetical protein -
  A7J09_RS11190 (A7J09_11410) - 2329305..2329511 (+) 207 WP_024404519.1 hypothetical protein -
  A7J09_RS11195 (A7J09_11415) - 2329523..2329723 (-) 201 WP_029178371.1 hypothetical protein -
  A7J09_RS11200 (A7J09_11420) - 2329788..2330153 (-) 366 WP_029178372.1 hypothetical protein -
  A7J09_RS11205 (A7J09_11425) - 2330233..2330421 (+) 189 WP_029178373.1 hypothetical protein -
  A7J09_RS11210 (A7J09_11430) - 2330396..2330581 (-) 186 WP_029178374.1 hypothetical protein -
  A7J09_RS11215 (A7J09_11435) - 2330871..2331230 (+) 360 WP_029178375.1 helix-turn-helix domain-containing protein -
  A7J09_RS11220 (A7J09_11440) - 2331240..2331461 (+) 222 WP_024399050.1 DUF6290 family protein -
  A7J09_RS11225 (A7J09_11445) - 2331451..2331726 (+) 276 WP_024399051.1 type II toxin-antitoxin system RelE family toxin -
  A7J09_RS11230 (A7J09_11450) - 2331741..2332121 (+) 381 WP_029178376.1 ImmA/IrrE family metallo-endopeptidase -
  A7J09_RS11235 (A7J09_11455) - 2332171..2332773 (+) 603 WP_053861558.1 CD20-like domain-containing protein -
  A7J09_RS11240 (A7J09_11460) - 2333039..2334124 (+) 1086 WP_029178378.1 tyrosine-type recombinase/integrase -

Sequence

Protein


Download         Length: 817 a.a.        Molecular weight: 90493.03 Da        Isoelectric Point: 6.2908

>NTDB_id=298288 A7J09_RS10955 WP_029175047.1 2295738..2298191(-) (clpC) [Streptococcus suis strain ISU2812]
MKISTGLQRVFEDAQLVAQRYACDYLETWHVLLSFVINHDTVAGAVLAEYPISISDYEHATFVVTDKVYREELDSFRILP
SSKRLDETASFAKKIAEVVKAKELGTEHLFMAMLLDKRSTASQILDKVGFCFEDSDDKFRFLDLRKNLEARAGFTKEDLK
AIRSVMKGGKAKPANMGQMMGMPPAPQSGGLEDYTRDLTALAREGKIEPVIGRDAEIARMIQILSRKTKNNPVLVGDAGV
GKTVLALGLAQRVAAGDVPVSLAKMRVLELDLMNVIAGTRFRGDFEERMNNIINDIEEDGQVILFIDELHTIMGSGSGID
STLDAANILKPALARGTLRTVGATTQTEYQKHIEKDAALVRRFAKVTIEEPTVEDSIAILTGLKGTFEKYHRVRIGQATV
ETAVTYAKRYLTSKNLPDSAIDLLDEASATVQNRVKGQAEETGLTSIDKALMDKKYKTVSKLLIKTKEDAEASQNYDIEV
TEEDVLETLSRLSGITVAKLSQSDTKKYLNLEAELHKRVIGQEEAISAVSRAIRRNQSGIRTGRRPIGSFMFLGPTGVGK
TELAKALAEVLFDDESALIRFDMSEYMEKFATSRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLL
QVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGALDLSKDHKEVEKRIFEELKKAYRPEFINRIDEKVVF
HSLTESHMQDVVKVMIKPLLAVTAEKGITLKLQPSALKLLAKQGYDPEMGARPLRRLLQTKLEDPLAEMLLRGDLTTGST
LKVGVKGEELKFDVVKG

Nucleotide


Download         Length: 2454 bp        

>NTDB_id=298288 A7J09_RS10955 WP_029175047.1 2295738..2298191(-) (clpC) [Streptococcus suis strain ISU2812]
ATGAAAATTTCAACTGGTTTACAGCGGGTTTTTGAAGATGCCCAGTTAGTGGCCCAACGTTATGCCTGTGATTACTTGGA
AACCTGGCATGTTCTCTTGTCTTTCGTTATCAACCATGATACAGTCGCTGGCGCTGTTTTGGCAGAATATCCTATTTCAA
TTTCTGACTATGAACATGCAACTTTTGTTGTGACCGACAAGGTCTATCGTGAAGAGTTGGATAGTTTTCGTATTTTACCA
TCTTCTAAACGTTTGGATGAAACAGCTAGTTTTGCCAAGAAAATTGCAGAAGTCGTCAAGGCTAAGGAGTTGGGAACGGA
ACATTTGTTTATGGCTATGTTGTTGGACAAGCGGTCAACAGCTAGTCAGATTTTGGACAAGGTAGGTTTTTGTTTTGAAG
ACTCAGATGATAAGTTTCGTTTCTTGGATTTGCGTAAAAACTTGGAGGCACGTGCGGGATTTACCAAAGAGGACCTTAAA
GCTATCCGCAGTGTGATGAAGGGTGGCAAAGCCAAACCTGCCAATATGGGACAGATGATGGGAATGCCCCCAGCACCTCA
AAGTGGTGGATTAGAAGACTACACTCGTGATTTGACAGCTTTGGCGCGTGAAGGGAAGATTGAACCTGTCATCGGTCGAG
ACGCTGAGATTGCACGGATGATCCAAATTCTATCACGTAAAACCAAGAATAACCCAGTTCTAGTTGGTGATGCTGGTGTC
GGAAAAACTGTGCTTGCTTTGGGTCTTGCTCAACGTGTTGCTGCAGGTGATGTTCCTGTCAGCTTAGCTAAGATGCGGGT
TTTGGAACTTGACTTGATGAACGTTATCGCTGGAACTCGTTTCCGTGGTGATTTCGAAGAGCGGATGAATAATATCATCA
ACGACATCGAGGAAGATGGTCAGGTCATCCTTTTCATCGATGAGTTGCATACCATTATGGGTTCTGGCTCGGGGATTGAT
TCGACCTTGGACGCAGCCAATATCCTCAAACCAGCTCTTGCTCGTGGCACCCTCCGTACGGTCGGAGCGACGACTCAGAC
AGAGTACCAAAAGCATATTGAGAAAGACGCAGCCCTGGTTCGTCGTTTTGCCAAAGTGACCATTGAAGAGCCGACAGTGG
AAGATAGCATTGCCATTTTGACTGGTTTAAAAGGTACTTTTGAAAAATACCACAGGGTCCGTATTGGACAAGCAACTGTA
GAGACTGCTGTGACCTACGCTAAGCGGTATTTGACCAGTAAAAACCTGCCAGATTCAGCCATTGACTTGCTGGATGAAGC
CAGTGCAACGGTACAAAATCGAGTGAAAGGGCAGGCTGAGGAAACAGGACTGACGAGCATAGACAAGGCCTTGATGGATA
AAAAATATAAGACTGTCAGCAAGCTTTTGATTAAAACGAAAGAAGATGCCGAGGCTAGTCAAAACTATGACATTGAAGTA
ACAGAAGAAGATGTTTTAGAGACACTTAGTCGCTTGTCAGGTATCACAGTAGCCAAGCTTAGCCAATCAGATACTAAGAA
GTATCTGAATCTGGAAGCAGAATTGCACAAGCGTGTGATTGGGCAGGAAGAAGCTATTTCTGCAGTTAGCAGAGCTATTC
GCCGTAATCAGTCAGGGATTCGTACAGGTCGCAGACCGATTGGCTCCTTTATGTTCTTGGGACCAACTGGTGTCGGTAAG
ACAGAGCTTGCTAAAGCCTTGGCAGAGGTTCTCTTTGATGATGAATCCGCTCTTATCCGTTTTGATATGTCTGAGTATAT
GGAGAAATTTGCGACCAGCCGTCTCAATGGAGCGCCGCCAGGCTACGTGGGCTATGAAGAAGGTGGCGAATTGACGGAAA
AAGTTCGTAACAAACCTTATTCTGTTCTTCTTTTTGATGAGGTTGAAAAGGCTCATCCAGATATTTTCAATGTTCTCTTG
CAGGTCTTGGATGATGGTGTCTTGACGGACAGTAAGGGACGTAAGGTTGATTTCTCAAATACCATTATTATCATGACGTC
AAACCTTGGAGCAACAGCTCTTCGGGATGATAAGACAGTTGGCTTTGGTGCCCTTGATTTATCTAAGGATCACAAGGAAG
TGGAGAAACGCATTTTTGAGGAATTGAAAAAAGCCTATCGTCCAGAATTTATCAACCGTATTGACGAGAAAGTTGTCTTC
CATAGCTTGACAGAATCCCATATGCAGGATGTTGTCAAGGTCATGATTAAACCTTTATTGGCTGTAACAGCTGAGAAAGG
AATTACCCTTAAACTGCAACCGTCAGCCCTTAAGTTATTGGCTAAACAAGGTTACGACCCAGAAATGGGGGCTCGTCCGC
TACGTAGGCTCTTACAAACCAAATTGGAAGATCCGTTGGCAGAAATGTTGCTCCGTGGTGACTTGACTACTGGTTCGACC
TTGAAGGTTGGGGTCAAGGGTGAAGAGCTCAAGTTTGATGTGGTAAAGGGATAA

Domains

Predicted by InterproScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(233-365)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(723-803)

AAA domain (Cdc48 subfamily) (AAA_2)

(545-716)

AAA lid domain (AAA_lid_9)

(372-457)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(102-129)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(14-56)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus pneumoniae TIGR4

71.411

99.755

0.712
  clpC Streptococcus pneumoniae Rx1

71.411

99.755

0.712
  clpC Streptococcus pneumoniae D39

71.411

99.755

0.712
  clpC Streptococcus mutans UA159

66.216

99.633

0.66
  clpC Streptococcus thermophilus LMG 18311

64.019

100

0.651
  clpC Streptococcus thermophilus LMD-9

63.899

100

0.65
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

48.982

100

0.501
  clpC Bacillus subtilis subsp. subtilis str. 168

42.994

100

0.439

Multiple sequence alignment