Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   LHV_RS09070 Genome accession   NC_010080
Coordinates   1803301..1805097 (+) Length   598 a.a.
NCBI ID   WP_012212264.1    Uniprot ID   A8YXA8
Organism   Lactobacillus helveticus DPC 4571     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1780555..1809839 1803301..1805097 within 0
IScluster/Tn 1800321..1806339 1803301..1805097 within 0


Gene organization within MGE regions


Location: 1780555..1809839
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LHV_RS08935 - 1780555..1781511 (-) 957 WP_041810744.1 C40 family peptidase -
  LHV_RS08940 - 1781649..1782425 (-) 777 WP_041810745.1 C40 family peptidase -
  LHV_RS08945 (lhv_1810) - 1782651..1782965 (-) 315 WP_237698136.1 DUF234 domain-containing protein -
  LHV_RS08950 (lhv_2924) - 1783326..1784888 (-) 1563 WP_023062123.1 RNA-guided endonuclease TnpB family protein -
  LHV_RS08955 (lhv_2923) - 1784842..1785492 (-) 651 WP_012212409.1 IS607-like element ISLhe9 family transposase -
  LHV_RS08960 - 1785528..1785740 (-) 213 WP_041810747.1 hypothetical protein -
  LHV_RS08965 - 1785759..1786040 (-) 282 WP_041810748.1 AAA family ATPase -
  LHV_RS08970 - 1786051..1786488 (-) 438 WP_080516440.1 AAA family ATPase -
  LHV_RS08975 (lhv_1816) - 1786609..1787160 (-) 552 WP_012212252.1 C40 family peptidase -
  LHV_RS08980 (lhv_1817) - 1787350..1787895 (-) 546 WP_012212253.1 guanylate kinase -
  LHV_RS08985 (lhv_1818) - 1787989..1788288 (+) 300 WP_041810749.1 DUF2187 domain-containing protein -
  LHV_RS08990 (lhv_1819) - 1788381..1789886 (+) 1506 WP_012212255.1 O-antigen ligase family protein -
  LHV_RS08995 (lhv_1820) - 1789901..1790540 (-) 640 Protein_1786 LVIS_2131 family protein -
  LHV_RS09000 - 1790786..1791975 (-) 1190 Protein_1787 RNA-guided endonuclease InsQ/TnpB family protein -
  LHV_RS09005 (lhv_1823) - 1792293..1792640 (-) 348 WP_012212257.1 hypothetical protein -
  LHV_RS09010 (lhv_1824) - 1792753..1793289 (-) 537 WP_012212258.1 hypothetical protein -
  LHV_RS09015 (lhv_1825) - 1793529..1794770 (-) 1242 WP_012212259.1 RNA-guided endonuclease TnpB family protein -
  LHV_RS09020 (lhv_1826) - 1795046..1795633 (+) 588 WP_207783603.1 C39 family peptidase -
  LHV_RS09025 (lhv_1827) - 1795838..1796323 (-) 486 WP_012212260.1 threonine/serine exporter family protein -
  LHV_RS09030 (lhv_1828) - 1796326..1797096 (-) 771 WP_012212261.1 threonine/serine exporter family protein -
  LHV_RS09035 (lhv_1829) - 1797107..1798648 (-) 1542 WP_012212262.1 ABC-F family ATP-binding cassette domain-containing protein -
  LHV_RS09040 - 1798657..1799034 (-) 378 WP_023190894.1 hypothetical protein -
  LHV_RS09045 (lhv_1831) - 1799226..1799723 (+) 498 WP_229020345.1 GNAT family N-acetyltransferase -
  LHV_RS09050 - 1799720..1800225 (-) 506 Protein_1797 DUF554 family protein -
  LHV_RS09055 - 1800321..1801539 (-) 1219 Protein_1798 RNA-guided endonuclease TnpB family protein -
  LHV_RS09060 - 1801631..1801819 (-) 189 Protein_1799 DUF554 family protein -
  LHV_RS09065 (lhv_1834) - 1801888..1803129 (-) 1242 WP_012212263.1 LCP family protein -
  LHV_RS09070 (lhv_1835) pepF 1803301..1805097 (+) 1797 WP_012212264.1 oligoendopeptidase F Regulator
  LHV_RS09075 (lhv_1837) - 1805421..1805678 (+) 258 WP_012212265.1 Fic family protein -
  LHV_RS09085 - 1805965..1806339 (+) 375 Protein_1803 transposase -
  LHV_RS09090 (lhv_1839) - 1806584..1807960 (-) 1377 WP_023190802.1 L-cystine transporter -
  LHV_RS09095 (lhv_1840) - 1808398..1809192 (-) 795 WP_003627328.1 metal ABC transporter permease -
  LHV_RS09100 (lhv_1841) - 1809192..1809839 (-) 648 WP_012212267.1 metal ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 598 a.a.        Molecular weight: 68096.17 Da        Isoelectric Point: 4.9296

>NTDB_id=29569 LHV_RS09070 WP_012212264.1 1803301..1805097(+) (pepF) [Lactobacillus helveticus DPC 4571]
MAIPTRSEVPEDLKWDLTRIFKTDQDWENAFDKAKDDVAKLSELKGSLAKSGKDLYEGLTKILAVKRDVENIYVYATMSS
DVDTSNSHYLGYVSRMQSLSNQFEAATSFINPEILSIPAEKFEQFKKDEPRLADYAHYLEMITNKRPHTLPAEEEKIIAD
AGDAMSVSENTFNVLTNSDMEYGYVQDEDGNMEQLSNGLYSLLIQSQNRDVRKGAFNTLYASYGQFQNSLASTLSGVVKK
HNYNARMHKYDSAREAALADNGVPVEVYDTLIKEVDSHLDLLHRYVALRKKILGLKDLQMWDMYVPLTGKPALSYNFEEA
KKVAKEALKPLGEDYLKHVDYIFNNRVIDPVESKGKVTGAYSGGAYDTDPYELLNWEDNIDSLYTLVHETGHSVHSWYTR
HSQPYIYGNYPIFVAEIASTTNENILTEYFLDHITDPKTRAFILNHYLDSFKGTLFRQTQFAVFEQFIHEADAKGEPLTA
DILNDVYGQINQHYYGDSVEPGGDIALEWSRIPHFYYNFYVYQYATGFAAATALANKVVHGSQADRDAYLGYLKSGSSDY
PTEIMKRAGVDMTKPDYLKDAFKTFEKRLNEFESLIGK

Nucleotide


Download         Length: 1797 bp        

>NTDB_id=29569 LHV_RS09070 WP_012212264.1 1803301..1805097(+) (pepF) [Lactobacillus helveticus DPC 4571]
ATGGCGATTCCAACAAGAAGCGAAGTCCCAGAAGATTTGAAGTGGGATTTAACCCGCATCTTTAAAACAGACCAAGACTG
GGAAAATGCCTTTGACAAGGCAAAAGATGACGTGGCTAAGCTAAGTGAATTAAAGGGAAGCTTGGCTAAATCAGGCAAAG
ATTTGTATGAAGGCTTGACCAAGATTTTGGCAGTTAAACGTGATGTAGAAAATATTTACGTTTATGCCACTATGTCTAGC
GATGTTGATACTTCTAACTCACATTATTTGGGCTACGTTAGCCGCATGCAAAGCTTGTCCAATCAATTTGAAGCAGCAAC
CAGTTTTATTAATCCTGAAATTTTGAGTATCCCTGCCGAAAAGTTTGAACAATTCAAAAAAGACGAGCCAAGATTAGCTG
ATTACGCCCACTATTTGGAAATGATCACTAACAAGCGTCCTCATACTTTGCCAGCAGAAGAAGAAAAAATTATCGCTGAC
GCAGGGGATGCCATGAGCGTGTCAGAGAATACCTTTAACGTTTTAACCAACTCTGACATGGAATATGGTTATGTGCAAGA
TGAAGACGGCAACATGGAGCAATTATCCAATGGCTTGTATTCATTATTGATTCAGTCCCAAAATCGTGACGTGCGTAAAG
GTGCTTTTAATACTCTCTATGCCAGCTATGGTCAATTCCAAAACTCGCTTGCCTCTACTCTCTCCGGCGTTGTGAAAAAA
CATAACTACAACGCACGCATGCACAAGTATGATTCAGCTCGTGAAGCCGCATTAGCTGATAACGGCGTACCTGTTGAAGT
TTACGACACATTAATTAAAGAAGTTGATTCACACCTTGACTTGCTTCACCGTTATGTCGCATTGCGCAAGAAAATTTTAG
GTCTTAAAGACTTACAAATGTGGGACATGTACGTGCCGCTAACTGGTAAGCCTGCTTTGTCTTACAACTTTGAAGAGGCT
AAAAAGGTAGCTAAAGAAGCCTTGAAGCCACTTGGCGAAGACTACTTAAAGCATGTTGATTATATTTTTAACAACCGTGT
GATTGATCCTGTTGAATCTAAGGGCAAGGTTACTGGTGCTTACTCTGGTGGTGCTTACGATACCGATCCATATGAACTTT
TGAACTGGGAAGACAATATCGATTCACTCTATACTTTAGTTCATGAAACTGGACACTCAGTTCACTCTTGGTACACCCGC
CACAGTCAGCCTTATATCTATGGTAATTACCCAATCTTCGTGGCTGAAATTGCTTCAACCACTAATGAAAATATTTTGAC
TGAATATTTCTTGGACCATATTACTGATCCTAAGACGCGCGCATTCATCTTGAACCACTACCTTGATTCATTCAAGGGTA
CATTGTTCCGCCAAACTCAATTTGCGGTATTTGAACAATTTATCCACGAAGCAGATGCTAAGGGCGAACCATTGACTGCC
GATATTTTGAATGATGTTTATGGTCAAATTAACCAGCATTACTACGGCGACAGTGTTGAACCTGGTGGCGATATTGCGCT
TGAATGGTCACGAATTCCGCACTTCTACTACAACTTCTACGTTTATCAATATGCGACTGGATTTGCGGCTGCAACGGCTT
TGGCTAACAAGGTTGTGCATGGTAGTCAGGCTGATAGGGATGCATACCTGGGCTACCTTAAGTCAGGTTCTAGTGACTAT
CCTACTGAGATCATGAAGCGTGCCGGCGTTGACATGACTAAGCCCGATTATTTGAAAGATGCTTTCAAGACTTTTGAAAA
GAGATTGAACGAATTCGAGAGTTTGATTGGTAAGTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(203-583)

Oligopeptidase F (Peptidase_M3_N)

(113-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A8YXA8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

51.684

99.331

0.513

Multiple sequence alignment