Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DMC40_RS08395 Genome accession   NZ_CP029694
Coordinates   1584636..1585322 (-) Length   228 a.a.
NCBI ID   WP_111677052.1    Uniprot ID   A0A5K8APQ0
Organism   Streptococcus pyogenes strain ABC020055975     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1579636..1590322
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DMC40_RS08375 (DMC40_08370) dnaI 1580357..1581259 (-) 903 WP_002991016.1 primosomal protein DnaI -
  DMC40_RS08380 (DMC40_08375) - 1581260..1582435 (-) 1176 WP_011054202.1 replication initiation and membrane attachment family protein -
  DMC40_RS08385 (DMC40_08380) nrdR 1582419..1582913 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  DMC40_RS08390 (DMC40_08385) covS 1583128..1584630 (-) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  DMC40_RS08395 (DMC40_08390) covR 1584636..1585322 (-) 687 WP_111677052.1 two-component system response regulator CovR Regulator
  DMC40_RS08400 (DMC40_08395) - 1585590..1586123 (-) 534 WP_011054200.1 DUF177 domain-containing protein -
  DMC40_RS08405 (DMC40_08400) htpX 1586357..1587253 (-) 897 WP_011054199.1 zinc metalloprotease HtpX -
  DMC40_RS08410 (DMC40_08405) - 1587300..1587857 (-) 558 WP_002985956.1 LemA family protein -
  DMC40_RS08415 (DMC40_08410) rsmG 1588007..1588720 (+) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DMC40_RS08420 (DMC40_08415) ktrB 1588804..1590180 (+) 1377 WP_032461391.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26599.65 Da        Isoelectric Point: 4.6576

>NTDB_id=295442 DMC40_RS08395 WP_111677052.1 1584636..1585322(-) (covR) [Streptococcus pyogenes strain ABC020055975]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTHRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=295442 DMC40_RS08395 WP_111677052.1 1584636..1585322(-) (covR) [Streptococcus pyogenes strain ABC020055975]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGGTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCATCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5K8APQ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

81.659

100

0.82
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.52

99.561

0.662
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment