Detailed information NTG0295424

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DMC40_RS03825
• Genome accession: NZ_CP029694
• Coordinates: 690305..691342 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain ABC020055975
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 685305..696342

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DMC40_RS03800 (DMC40_03800)	-	685569..686900 (+)	1332	WP_011054719.1	dipeptidase	-
DMC40_RS03805 (DMC40_03805)	arcC	686920..687870 (+)	951	WP_003051912.1	carbamate kinase	-
DMC40_RS03810 (DMC40_03810)	asnA	688183..689175 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
DMC40_RS03815 (DMC40_03815)	rsmD	689298..689837 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DMC40_RS03820 (DMC40_03820)	coaD	689827..690318 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DMC40_RS03825 (DMC40_03825)	sepM	690305..691342 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DMC40_RS03830 (DMC40_03830)	-	691756..692733 (+)	978	WP_011054718.1	LacI family DNA-binding transcriptional regulator	-
DMC40_RS03835 (DMC40_03835)	-	693181..693801 (+)	621	WP_002992791.1	YutD family protein	-
DMC40_RS03840 (DMC40_03840)	rlmN	693805..694884 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DMC40_RS03845 (DMC40_03845)	-	694966..695592 (-)	627	WP_002989076.1	A24 family peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=295424 DMC40_RS03825 WP_010922499.1 690305..691342(+) (sepM) [Streptococcus pyogenes strain ABC020055975]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=295424 DMC40_RS03825 WP_010922499.1 690305..691342(+) (sepM) [Streptococcus pyogenes strain ABC020055975]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693