Detailed information NTG0295159

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: CSB71_RS13340
• Genome accession: NZ_CP029680
• Coordinates: 2480090..2481439 (+)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain AR_0215
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2480090..2501455	2480090..2481439	within	0

Gene organization within MGE regions

Location: 2480090..2501455

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSB71_RS13340 (CSB71_2442)	ccrA	2480090..2481439 (+)	1350	WP_000815646.1	recombinase family protein	Machinery gene
CSB71_RS13345 (CSB71_2443)	ccrB	2481461..2483089 (+)	1629	WP_001186602.1	recombinase family protein	Machinery gene
CSB71_RS13350 (CSB71_2444)	-	2483607..2483957 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
CSB71_RS13355 (CSB71_2445)	-	2484044..2484355 (+)	312	WP_000700853.1	DUF960 family protein	-
CSB71_RS13360 (CSB71_2446)	-	2484373..2484879 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
CSB71_RS13365 (CSB71_2447)	-	2484900..2485217 (+)	318	WP_000659050.1	JAB domain-containing protein	-
CSB71_RS13370 (CSB71_2448)	-	2485336..2486421 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
CSB71_RS13375 (CSB71_2449)	-	2486418..2488310 (+)	1893	WP_001557544.1	site-specific integrase	-
CSB71_RS13380 (CSB71_2450)	-	2488317..2488694 (+)	378	WP_000361059.1	DUF6262 family protein	-
CSB71_RS13385 (CSB71_2451)	-	2488845..2489627 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
CSB71_RS13390 (CSB71_2452)	erm(A)	2489753..2490484 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
CSB71_RS13405 (CSB71_2453)	-	2491018..2491680 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
CSB71_RS13415	-	2492025..2492663 (-)	639	Protein_2485	sulfite exporter TauE/SafE family protein	-
CSB71_RS13420 (CSB71_2455)	cstR	2492663..2492923 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
CSB71_RS13425 (CSB71_2456)	-	2493059..2494123 (+)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
CSB71_RS13430 (CSB71_2457)	cstB	2494156..2495490 (+)	1335	Protein_2488	persulfide dioxygenase-sulfurtransferase CstB	-
CSB71_RS13440 (CSB71_2459)	-	2495604..2496734 (-)	1131	WP_010922808.1	ROK family transcriptional regulator	-
CSB71_RS13445	psm-mec	2497068..2497136 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
CSB71_RS13450 (CSB71_2460)	mecI	2497221..2497592 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
CSB71_RS13455 (CSB71_2461)	mecR1	2497592..2499349 (-)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
CSB71_RS13460 (CSB71_2462)	mecA	2499446..2501455 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=295159 CSB71_RS13340 WP_000815646.1 2480090..2481439(+) (ccrA) [Staphylococcus aureus strain AR_0215]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=295159 CSB71_RS13340 WP_000815646.1 2480090..2481439(+) (ccrA) [Staphylococcus aureus strain AR_0215]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748