Detailed information NTG0295069

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CSB75_RS10615
• Genome accession: NZ_CP029675
• Coordinates: 2024565..2025608 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017146.1
• Uniprot ID: Q7A2Q0
• Organism: Staphylococcus aureus strain AR_0219
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2019565..2030608

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSB75_RS10585 (CSB75_1943)	-	2019986..2021242 (-)	1257	WP_001795108.1	aminopeptidase	-
CSB75_RS10590 (CSB75_1944)	-	2021245..2021445 (-)	201	WP_000180460.1	DUF1128 family protein	-
CSB75_RS10595 (CSB75_1945)	-	2021592..2022056 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CSB75_RS10600 (CSB75_1946)	-	2022063..2022338 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
CSB75_RS10605 (CSB75_1947)	-	2022616..2023833 (+)	1218	WP_000037068.1	YihY/virulence factor BrkB family protein	-
CSB75_RS10610 (CSB75_1948)	vraR	2023946..2024575 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
CSB75_RS10615 (CSB75_1949)	vraS	2024565..2025608 (-)	1044	WP_001017146.1	histidine kinase	Regulator
CSB75_RS10620 (CSB75_1950)	liaF	2025605..2026306 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CSB75_RS10625 (CSB75_1951)	-	2026321..2026707 (-)	387	WP_001110179.1	hypothetical protein	-
CSB75_RS10630 (CSB75_1952)	map	2026924..2027682 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CSB75_RS10640 (CSB75_1953)	-	2028213..2029199 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
CSB75_RS10650 (CSB75_1954)	-	2029630..2030043 (-)	414	WP_001557448.1	hypothetical protein	-
CSB75_RS10655	-	2030072..2030182 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40045.46 Da
• Isoelectric Point: 6.0577

>NTDB_id=295069 CSB75_RS10615 WP_001017146.1 2024565..2025608(-) (vraS) [Staphylococcus aureus strain AR_0219]
MNHYNRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=295069 CSB75_RS10615 WP_001017146.1 2024565..2025608(-) (vraS) [Staphylococcus aureus strain AR_0219]
ATGAACCACTACAATAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• PDB: 4GT8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	99.712	100	0.997