Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | CSB75_RS00490 | Genome accession | NZ_CP029675 |
| Coordinates | 64492..65841 (-) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain AR_0219 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 57627..101346 | 64492..65841 | within | 0 |
| SCCmec | 44482..65841 | 64492..65841 | within | 0 |
Gene organization within MGE regions
Location: 44482..101346
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CSB75_RS00370 (CSB75_0040) | mecA | 44482..46491 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| CSB75_RS00375 (CSB75_0041) | mecR1 | 46588..48345 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| CSB75_RS00380 (CSB75_0042) | mecI | 48345..48716 (+) | 372 | WP_000369211.1 | mecA-type methicillin resistance repressor MecI | - |
| CSB75_RS00385 | psm-mec | 48801..48869 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| CSB75_RS00390 (CSB75_0043) | - | 49203..50333 (+) | 1131 | WP_010924741.1 | ROK family transcriptional regulator | - |
| CSB75_RS00400 (CSB75_0045) | cstB | 50447..51781 (-) | 1335 | Protein_40 | persulfide dioxygenase-sulfurtransferase CstB | - |
| CSB75_RS00405 (CSB75_0046) | - | 51814..52878 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| CSB75_RS00410 (CSB75_0047) | cstR | 53014..53274 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| CSB75_RS00415 (CSB75_0048) | - | 53274..53912 (+) | 639 | Protein_43 | sulfite exporter TauE/SafE family protein | - |
| CSB75_RS00425 (CSB75_0049) | - | 54257..54919 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| CSB75_RS00440 (CSB75_0050) | erm(A) | 55453..56184 (+) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| CSB75_RS00445 (CSB75_0051) | - | 56310..57092 (-) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| CSB75_RS00450 (CSB75_0052) | - | 57243..57620 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| CSB75_RS00455 (CSB75_0053) | - | 57627..59518 (-) | 1892 | Protein_48 | site-specific integrase | - |
| CSB75_RS15505 | - | 59515..60595 (-) | 1081 | Protein_49 | tyrosine-type recombinase/integrase | - |
| CSB75_RS00465 (CSB75_0057) | - | 60714..61031 (-) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| CSB75_RS00470 (CSB75_0058) | - | 61052..61558 (-) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| CSB75_RS00475 (CSB75_0059) | - | 61576..61887 (-) | 312 | WP_000700853.1 | DUF960 family protein | - |
| CSB75_RS00480 (CSB75_0060) | - | 61974..62324 (-) | 351 | WP_000859153.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| CSB75_RS00485 (CSB75_0061) | ccrB | 62842..64470 (-) | 1629 | WP_001186602.1 | recombinase family protein | Machinery gene |
| CSB75_RS00490 (CSB75_0062) | ccrA | 64492..65841 (-) | 1350 | WP_000815646.1 | recombinase family protein | Machinery gene |
| CSB75_RS00495 (CSB75_0063) | - | 66075..67868 (-) | 1794 | WP_000195100.1 | DUF927 domain-containing protein | - |
| CSB75_RS00500 (CSB75_0064) | - | 67868..68164 (-) | 297 | WP_000273824.1 | single-stranded DNA-binding protein | - |
| CSB75_RS00505 (CSB75_0065) | - | 68357..69403 (-) | 1047 | WP_001060127.1 | hypothetical protein | - |
| CSB75_RS00510 | - | 69654..70795 (-) | 1142 | Protein_59 | IS3-like element ISSau4 family transposase | - |
| CSB75_RS15510 (CSB75_0069) | - | 70965..71099 (+) | 135 | WP_001792216.1 | hypothetical protein | - |
| CSB75_RS00515 (CSB75_0070) | - | 71306..72232 (-) | 927 | Protein_61 | YfcC family protein | - |
| CSB75_RS00520 (CSB75_0071) | - | 72954..73649 (-) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| CSB75_RS00525 (CSB75_0072) | - | 73624..76293 (-) | 2670 | Protein_63 | sensor histidine kinase KdpD | - |
| CSB75_RS00530 | kdpF | 76460..76540 (+) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| CSB75_RS00535 (CSB75_0073) | kdpA | 76561..78237 (+) | 1677 | WP_000029430.1 | potassium-transporting ATPase subunit KdpA | - |
| CSB75_RS00540 (CSB75_0074) | - | 78256..80277 (+) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| CSB75_RS00545 (CSB75_0075) | - | 80293..80850 (+) | 558 | WP_001193482.1 | K(+)-transporting ATPase subunit C | - |
| CSB75_RS00550 (CSB75_0076) | - | 81395..82264 (-) | 870 | WP_000626133.1 | hypothetical protein | - |
| CSB75_RS00555 (CSB75_0077) | - | 82274..83170 (-) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| CSB75_RS00565 (CSB75_0079) | - | 84289..84915 (-) | 627 | WP_001176969.1 | hypothetical protein | - |
| CSB75_RS00570 (CSB75_0080) | - | 85030..86538 (+) | 1509 | WP_001001347.1 | protein kinase | - |
| CSB75_RS00575 | - | 86788..86922 (-) | 135 | WP_001790628.1 | hypothetical protein | - |
| CSB75_RS00580 | - | 86886..86978 (+) | 93 | WP_001790000.1 | hypothetical protein | - |
| CSB75_RS00585 (CSB75_0081) | - | 87125..88870 (+) | 1746 | WP_000700190.1 | DUF6119 family protein | - |
| CSB75_RS00590 (CSB75_0082) | - | 88968..89323 (-) | 356 | Protein_75 | tRNA-dihydrouridine synthase | - |
| CSB75_RS00595 | - | 89628..89716 (-) | 89 | Protein_76 | hypothetical protein | - |
| CSB75_RS00600 (CSB75_0083) | - | 89814..90569 (-) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| CSB75_RS00605 (CSB75_0084) | cstR | 90569..90829 (-) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| CSB75_RS00610 (CSB75_0085) | cstA | 90966..92030 (+) | 1065 | WP_000816124.1 | persulfide response sulfurtransferase CstA | - |
| CSB75_RS00615 (CSB75_0086) | cstB | 92061..93395 (+) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| CSB75_RS00620 (CSB75_0087) | sqr | 93414..94607 (+) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| CSB75_RS15570 | - | 94874..95088 (-) | 215 | Protein_82 | universal stress protein | - |
| CSB75_RS00635 (CSB75_0088) | - | 95274..96260 (-) | 987 | WP_000662022.1 | tRNA-dihydrouridine synthase | - |
| CSB75_RS00640 | - | 96569..96772 (+) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| CSB75_RS00645 (CSB75_0089) | - | 96821..97117 (+) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| CSB75_RS00650 (CSB75_0090) | - | 97325..97927 (+) | 603 | WP_000908956.1 | hypothetical protein | - |
| CSB75_RS00655 (CSB75_0091) | - | 98194..101346 (+) | 3153 | WP_000080564.1 | DEAD/DEAH box helicase | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=295035 CSB75_RS00490 WP_000815646.1 64492..65841(-) (ccrA) [Staphylococcus aureus strain AR_0219]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=295035 CSB75_RS00490 WP_000815646.1 64492..65841(-) (ccrA) [Staphylococcus aureus strain AR_0219]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |