Detailed information NTG0294970

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CSB78_RS11380
• Genome accession: NZ_CP029671
• Coordinates: 2222172..2223215 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AR_0222
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2217172..2228215

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSB78_RS11340	-	2217598..2217708 (+)	111	WP_001790257.1	hypothetical protein	-
CSB78_RS11345 (CSB78_2039)	-	2217737..2218150 (+)	414	WP_001557448.1	hypothetical protein	-
CSB78_RS11355 (CSB78_2040)	-	2218581..2219567 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
CSB78_RS11365 (CSB78_2041)	map	2220098..2220856 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CSB78_RS11370 (CSB78_2042)	-	2221073..2221459 (+)	387	WP_001110179.1	hypothetical protein	-
CSB78_RS11375 (CSB78_2043)	liaF	2221474..2222175 (+)	702	WP_110411511.1	cell wall-active antibiotics response protein LiaF	-
CSB78_RS11380 (CSB78_2044)	vraS	2222172..2223215 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CSB78_RS11385 (CSB78_2045)	vraR	2223205..2223834 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
CSB78_RS11390 (CSB78_2046)	-	2223947..2225164 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
CSB78_RS11395 (CSB78_2047)	-	2225442..2225717 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
CSB78_RS11400 (CSB78_2048)	-	2225724..2226188 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CSB78_RS11405 (CSB78_2049)	-	2226335..2226535 (+)	201	WP_000180460.1	DUF1128 family protein	-
CSB78_RS11410 (CSB78_2050)	-	2226538..2227794 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=294970 CSB78_RS11380 WP_001017131.1 2222172..2223215(+) (vraS) [Staphylococcus aureus strain AR_0222]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=294970 CSB78_RS11380 WP_001017131.1 2222172..2223215(+) (vraS) [Staphylococcus aureus strain AR_0222]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1