Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | CSC55_RS00500 | Genome accession | NZ_CP029653 |
| Coordinates | 96491..98119 (-) | Length | 542 a.a. |
| NCBI ID | WP_001573629.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain AR_0470 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 40384..103551 | 96491..98119 | within | 0 |
Gene organization within MGE regions
Location: 40384..103551
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CSC55_RS00175 (CSC55_2263) | - | 40384..42060 (+) | 1677 | WP_000676596.1 | recombinase family protein | - |
| CSC55_RS00180 | - | 42166..42504 (+) | 339 | WP_000171559.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| CSC55_RS00185 (CSC55_2264) | - | 42600..42911 (+) | 312 | WP_001083109.1 | DUF960 family protein | - |
| CSC55_RS00190 (CSC55_2265) | - | 42927..43433 (+) | 507 | WP_000447786.1 | DUF1643 domain-containing protein | - |
| CSC55_RS00195 (CSC55_2266) | - | 43582..44256 (-) | 675 | WP_110183794.1 | IS6-like element IS257 family transposase | - |
| CSC55_RS00200 | - | 44340..44681 (+) | 342 | WP_001797647.1 | hydroxymethylglutaryl-CoA synthase | - |
| CSC55_RS00210 (CSC55_2268) | - | 45598..46341 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| CSC55_RS00215 (CSC55_2269) | - | 46438..46866 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| CSC55_RS00220 (CSC55_2270) | mecA | 46912..48921 (-) | 2010 | WP_063852638.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| CSC55_RS00225 | - | 49018..49125 (+) | 108 | Protein_39 | beta-lactam sensor/signal transducer MecR1 | - |
| CSC55_RS00230 | - | 49166..49840 (+) | 675 | Protein_40 | IS6 family transposase | - |
| CSC55_RS00235 (CSC55_2273) | - | 49900..50328 (-) | 429 | WP_000671996.1 | VOC family protein | - |
| CSC55_RS00240 (CSC55_2274) | - | 50409..51338 (+) | 930 | WP_000750311.1 | HTH domain-containing protein | - |
| CSC55_RS00245 (CSC55_2275) | - | 51500..53488 (+) | 1989 | WP_001038847.1 | hypothetical protein | - |
| CSC55_RS00250 (CSC55_2276) | - | 53683..54792 (+) | 1110 | WP_000283873.1 | DNA polymerase | - |
| CSC55_RS00255 (CSC55_2277) | - | 54785..55153 (+) | 369 | WP_001058155.1 | hypothetical protein | - |
| CSC55_RS00260 (CSC55_2278) | - | 55153..56769 (+) | 1617 | WP_001015575.1 | DUF5906 domain-containing protein | - |
| CSC55_RS00265 (CSC55_2279) | - | 56994..58673 (+) | 1680 | WP_000676592.1 | recombinase family protein | - |
| CSC55_RS00270 (CSC55_2280) | - | 58762..59100 (+) | 339 | WP_000175888.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| CSC55_RS00280 (CSC55_2281) | - | 59194..59505 (+) | 312 | WP_001024805.1 | DUF960 family protein | - |
| CSC55_RS00285 (CSC55_2282) | - | 59520..60023 (+) | 504 | WP_001092190.1 | DUF1643 domain-containing protein | - |
| CSC55_RS00290 (CSC55_2283) | - | 60038..60259 (+) | 222 | WP_001015193.1 | hypothetical protein | - |
| CSC55_RS15345 | - | 60332..60933 (-) | 602 | Protein_52 | DUF3387 domain-containing protein | - |
| CSC55_RS00305 (CSC55_2286) | cas1 | 62243..63148 (+) | 906 | WP_000655859.1 | type II CRISPR-associated endonuclease Cas1 | - |
| CSC55_RS00310 (CSC55_2287) | cas2 | 63148..63453 (+) | 306 | WP_000281076.1 | CRISPR-associated endonuclease Cas2 | - |
| CSC55_RS00315 (CSC55_2288) | cas10 | 63467..65740 (+) | 2274 | WP_000359017.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| CSC55_RS00320 (CSC55_2289) | csm2 | 65743..66168 (+) | 426 | WP_000599362.1 | type III-A CRISPR-associated protein Csm2 | - |
| CSC55_RS00325 (CSC55_2290) | csm3 | 66170..66814 (+) | 645 | WP_000286998.1 | type III-A CRISPR-associated RAMP protein Csm3 | - |
| CSC55_RS00330 (CSC55_2291) | csm4 | 66825..67733 (+) | 909 | WP_000208937.1 | type III-A CRISPR-associated RAMP protein Csm4 | - |
| CSC55_RS00335 (CSC55_2292) | csm5 | 67736..68758 (+) | 1023 | WP_000153149.1 | type III-A CRISPR-associated RAMP protein Csm5 | - |
| CSC55_RS00340 (CSC55_2293) | csm6 | 68758..70026 (+) | 1269 | WP_000865879.1 | type III-A CRISPR-associated CARF protein Csm6 | - |
| CSC55_RS00345 (CSC55_2294) | cas6 | 70023..70757 (+) | 735 | WP_000608705.1 | CRISPR-associated endoribonuclease Cas6 | - |
| CSC55_RS15260 (CSC55_2295) | - | 71867..72025 (+) | 159 | WP_000669699.1 | hypothetical protein | - |
| CSC55_RS00355 (CSC55_2296) | - | 72231..72584 (+) | 354 | Protein_63 | IS6-like element IS257 family transposase | - |
| CSC55_RS00360 (CSC55_2297) | lspA | 72612..73064 (-) | 453 | WP_204162947.1 | signal peptidase II | - |
| CSC55_RS00365 (CSC55_2298) | - | 73222..73623 (+) | 402 | WP_057504659.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| CSC55_RS00370 (CSC55_2299) | - | 73877..74644 (+) | 768 | WP_057504658.1 | ZIP family metal transporter | - |
| CSC55_RS00375 (CSC55_2300) | - | 74901..77075 (+) | 2175 | WP_110183796.1 | heavy metal translocating P-type ATPase | - |
| CSC55_RS00380 (CSC55_2301) | - | 77335..78534 (+) | 1200 | WP_343219445.1 | IS110-like element ISSep2 family transposase | - |
| CSC55_RS00385 (CSC55_2302) | - | 78631..80310 (-) | 1680 | WP_002503923.1 | IS1182-like element ISSep1 family transposase | - |
| CSC55_RS00390 (CSC55_2303) | lpdA | 80731..82152 (+) | 1422 | WP_162564164.1 | dihydrolipoyl dehydrogenase | - |
| CSC55_RS00395 (CSC55_2304) | - | 82380..83042 (+) | 663 | WP_049374230.1 | CadD family cadmium resistance transporter | - |
| CSC55_RS00400 (CSC55_2305) | - | 83551..84225 (-) | 675 | WP_110183799.1 | IS6-like element IS257 family transposase | - |
| CSC55_RS00405 (CSC55_2306) | - | 84508..85854 (+) | 1347 | WP_000163428.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| CSC55_RS00410 | merR | 86154..86561 (+) | 408 | WP_000425271.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| CSC55_RS00415 (CSC55_2308) | - | 86578..86931 (+) | 354 | WP_000746201.1 | TlpA disulfide reductase family protein | - |
| CSC55_RS00420 (CSC55_2309) | - | 86928..87608 (+) | 681 | WP_110183800.1 | cytochrome c biogenesis protein CcdA | - |
| CSC55_RS00425 | - | 87743..88081 (+) | 339 | WP_000968575.1 | hypothetical protein | - |
| CSC55_RS00430 (CSC55_2310) | merA | 88139..89782 (+) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| CSC55_RS00435 (CSC55_2311) | merB | 89864..90514 (+) | 651 | WP_000790334.1 | organomercurial lyase MerB | - |
| CSC55_RS00445 | - | 90709..91224 (-) | 516 | WP_000377077.1 | hypothetical protein | - |
| CSC55_RS00450 (CSC55_2313) | - | 91464..91670 (+) | 207 | WP_000253065.1 | hypothetical protein | - |
| CSC55_RS00455 (CSC55_2314) | - | 91782..91976 (+) | 195 | WP_000261373.1 | hypothetical protein | - |
| CSC55_RS00460 (CSC55_2315) | - | 92094..92768 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| CSC55_RS00465 (CSC55_2316) | - | 92825..93400 (+) | 576 | WP_275425261.1 | CDP-glycerol glycerophosphotransferase family protein | - |
| CSC55_RS00470 (CSC55_2317) | - | 93689..94186 (-) | 498 | WP_000776433.1 | GNAT family N-acetyltransferase | - |
| CSC55_RS00475 (CSC55_2318) | - | 94465..94686 (-) | 222 | WP_001015194.1 | hypothetical protein | - |
| CSC55_RS00480 (CSC55_2319) | - | 94700..95203 (-) | 504 | WP_001092191.1 | DUF1643 domain-containing protein | - |
| CSC55_RS00485 (CSC55_2320) | - | 95218..95529 (-) | 312 | WP_001166717.1 | DUF960 family protein | - |
| CSC55_RS00495 | - | 95616..95966 (-) | 351 | WP_000859152.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| CSC55_RS00500 (CSC55_2322) | ccrB | 96491..98119 (-) | 1629 | WP_001573629.1 | recombinase family protein | Machinery gene |
| CSC55_RS00505 (CSC55_2323) | ccrA | 98141..99490 (-) | 1350 | WP_001573628.1 | recombinase family protein | Machinery gene |
| CSC55_RS00510 (CSC55_2324) | - | 99724..101511 (-) | 1788 | WP_001573627.1 | DUF927 domain-containing protein | - |
| CSC55_RS00515 (CSC55_2325) | - | 101511..101825 (-) | 315 | WP_001573626.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62799.09 Da Isoelectric Point: 9.8480
>NTDB_id=294569 CSC55_RS00500 WP_001573629.1 96491..98119(-) (ccrB) [Staphylococcus aureus strain AR_0470]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKDGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRANVIEDYVMKQILEIVKSDKIIERVVARVNQENQVDCASLHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDIMYQINQLKNQQNEDKTLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKDGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRANVIEDYVMKQILEIVKSDKIIERVVARVNQENQVDCASLHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDIMYQINQLKNQQNEDKTLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
Nucleotide
Download Length: 1629 bp
>NTDB_id=294569 CSC55_RS00500 WP_001573629.1 96491..98119(-) (ccrB) [Staphylococcus aureus strain AR_0470]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTTTCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGATGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGTAAC
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGACATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCTCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACCAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTAATGTGATTGAAGATTATGTGATGAAGCAAATACTCGAAATAGTCAAAAGTGATAAAATCATTGAACGTGTTG
TAGCACGTGTTAACCAAGAAAATCAAGTTGATTGTGCGTCACTTCATCACGATATCGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTATGTATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGACTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATTAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTATTTT
TGCCCCAAACACTATATCTTACTATTTAG
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTTTCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGATGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGTAAC
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGACATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCTCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACCAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTAATGTGATTGAAGATTATGTGATGAAGCAAATACTCGAAATAGTCAAAAGTGATAAAATCATTGAACGTGTTG
TAGCACGTGTTAACCAAGAAAATCAAGTTGATTGTGCGTCACTTCATCACGATATCGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTATGTATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGACTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATTAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTATTTT
TGCCCCAAACACTATATCTTACTATTTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
97.97 |
100 |
0.98 |