Detailed information NTG0290936

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DD562_RS10690
• Genome accession: NZ_CP029172
• Coordinates: 2081733..2082776 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain PTDrAP2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2076733..2087776

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DD562_RS10660 (DD562_10660)	-	2077154..2078410 (-)	1257	WP_001793428.1	aminopeptidase	-
DD562_RS10665 (DD562_10665)	-	2078413..2078613 (-)	201	WP_000180460.1	DUF1128 family protein	-
DD562_RS10670 (DD562_10670)	-	2078760..2079224 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DD562_RS10675 (DD562_10675)	-	2079231..2079506 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DD562_RS10680 (DD562_10680)	-	2079784..2081001 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
DD562_RS10685 (DD562_10685)	vraR	2081114..2081743 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
DD562_RS10690 (DD562_10690)	vraS	2081733..2082776 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DD562_RS10695 (DD562_10695)	liaF	2082773..2083474 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DD562_RS10700 (DD562_10700)	-	2083489..2083875 (-)	387	WP_001110182.1	hypothetical protein	-
DD562_RS10705 (DD562_10705)	map	2084092..2084850 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
DD562_RS10715 (DD562_10715)	-	2085434..2086420 (+)	987	WP_000999712.1	FUSC family protein	-
DD562_RS10720 (DD562_10720)	-	2086609..2087022 (-)	414	WP_025174370.1	hypothetical protein	-
DD562_RS10725 (DD562_10725)	-	2087051..2087161 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=290936 DD562_RS10690 WP_001017131.1 2081733..2082776(-) (vraS) [Staphylococcus aureus strain PTDrAP2]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=290936 DD562_RS10690 WP_001017131.1 2081733..2082776(-) (vraS) [Staphylococcus aureus strain PTDrAP2]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1