Detailed information NTG0290259

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CSC48_RS02710
• Genome accession: NZ_CP029086
• Coordinates: 500352..501395 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AR462
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 495352..506395

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSC48_RS02680 (CSC48_0469)	-	495773..497029 (-)	1257	WP_001795108.1	aminopeptidase	-
CSC48_RS02685 (CSC48_0470)	-	497032..497232 (-)	201	WP_000180460.1	DUF1128 family protein	-
CSC48_RS02690 (CSC48_0471)	-	497379..497843 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CSC48_RS02695 (CSC48_0472)	-	497850..498125 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
CSC48_RS02700 (CSC48_0473)	-	498403..499620 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
CSC48_RS02705 (CSC48_0474)	vraR	499733..500362 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
CSC48_RS02710 (CSC48_0475)	vraS	500352..501395 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CSC48_RS02715 (CSC48_0476)	liaF	501392..502093 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CSC48_RS02720 (CSC48_0477)	-	502108..502494 (-)	387	WP_001110179.1	hypothetical protein	-
CSC48_RS02725 (CSC48_0478)	map	502711..503469 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CSC48_RS02735 (CSC48_0479)	-	504000..504986 (+)	987	WP_108720529.1	aromatic acid exporter family protein	-
CSC48_RS02745 (CSC48_0480)	-	505417..505830 (-)	414	WP_001557448.1	hypothetical protein	-
CSC48_RS02750	-	505859..505969 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=290259 CSC48_RS02710 WP_001017131.1 500352..501395(-) (vraS) [Staphylococcus aureus strain AR462]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=290259 CSC48_RS02710 WP_001017131.1 500352..501395(-) (vraS) [Staphylococcus aureus strain AR462]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1