Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA   Type   Machinery gene
Locus tag   CSC49_RS12060 Genome accession   NZ_CP029084
Coordinates   2362983..2363669 (-) Length   228 a.a.
NCBI ID   WP_072468915.1    Uniprot ID   A0A5F0HFN7
Organism   Staphylococcus aureus strain AR464     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 2357983..2368669
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CSC49_RS12040 (CSC49_2247) rpsT 2358897..2359148 (+) 252 WP_001274017.1 30S ribosomal protein S20 -
  CSC49_RS12045 (CSC49_2248) holA 2359193..2360167 (-) 975 WP_001282573.1 DNA polymerase III subunit delta -
  CSC49_RS12050 (CSC49_2249) comEC 2360224..2362425 (-) 2202 WP_001622275.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  CSC49_RS12055 (CSC49_2250) - 2362430..2362891 (-) 462 WP_000439693.1 ComE operon protein 2 -
  CSC49_RS12060 (CSC49_2251) comEA 2362983..2363669 (-) 687 WP_072468915.1 ComEA family DNA-binding protein Machinery gene
  CSC49_RS12065 (CSC49_2252) - 2363709..2364425 (-) 717 WP_000084840.1 class I SAM-dependent methyltransferase -
  CSC49_RS12070 (CSC49_2253) rsfS 2364428..2364781 (-) 354 WP_001088020.1 ribosome silencing factor -
  CSC49_RS12075 (CSC49_2254) yqeK 2364782..2365366 (-) 585 WP_001017837.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
  CSC49_RS12080 (CSC49_2255) nadD 2365356..2365925 (-) 570 WP_064135564.1 nicotinate (nicotinamide) nucleotide adenylyltransferase -
  CSC49_RS12085 (CSC49_2256) yhbY 2365928..2366218 (-) 291 WP_000955234.1 ribosome assembly RNA-binding protein YhbY -
  CSC49_RS12090 (CSC49_2257) aroE 2366222..2367028 (-) 807 WP_042744294.1 shikimate dehydrogenase -
  CSC49_RS12095 (CSC49_2258) yqeH 2367042..2368142 (-) 1101 WP_001280146.1 ribosome biogenesis GTPase YqeH -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 25812.41 Da        Isoelectric Point: 9.3305

>NTDB_id=290229 CSC49_RS12060 WP_072468915.1 2362983..2363669(-) (comEA) [Staphylococcus aureus strain AR464]
MVLLYQFLLRYKDFLTQWKLYIISAVVLIMVLIGFIFWRQDDYTSRDFENKDTALKQSTSENSSLSKLEDVQAKDGDNSK
NKGPVYVDIKGAVKHPNVYKMTSKDRVVDLLDKAQLLDDADVSQINLSEKLTDQKMIFIPHKGQKNVEPQFGENSVHVKN
GNTNNTKVNLNTASVSELMSVPGVGQAKANAIVEYRNQQGAFQEIDDLKKVKGFGSKTFDKLKSYFTT

Nucleotide


Download         Length: 687 bp        

>NTDB_id=290229 CSC49_RS12060 WP_072468915.1 2362983..2363669(-) (comEA) [Staphylococcus aureus strain AR464]
GTGGTTTTATTGTATCAATTTTTATTACGCTATAAAGATTTTTTAACTCAATGGAAGTTATATATTATAAGTGCTGTTGT
TTTAATTATGGTATTAATTGGTTTTATATTCTGGAGACAAGATGATTATACTTCAAGAGATTTTGAAAATAAAGATACTG
CTCTGAAACAAAGCACTAGTGAAAATAGTAGTTTGTCCAAATTAGAAGATGTCCAGGCCAAAGATGGAGATAATTCCAAA
AATAAAGGTCCTGTATATGTCGATATAAAAGGTGCTGTTAAACACCCTAATGTTTATAAAATGACATCTAAGGATAGAGT
AGTTGATTTACTTGATAAAGCACAATTATTGGATGATGCAGATGTAAGTCAAATTAATTTGTCTGAAAAATTAACAGATC
AAAAAATGATTTTCATTCCTCATAAAGGACAAAAGAATGTTGAACCACAATTTGGAGAAAACAGTGTGCACGTAAAAAAT
GGGAACACAAATAATACTAAAGTAAATTTAAATACGGCATCTGTATCAGAATTGATGTCTGTTCCTGGAGTAGGGCAAGC
TAAAGCTAATGCAATTGTTGAATATCGCAACCAACAAGGTGCATTTCAAGAAATTGACGATTTGAAAAAAGTAAAAGGTT
TTGGAAGTAAAACTTTTGATAAACTGAAATCTTATTTCACGACATAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(164-227)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5F0HFN7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA Staphylococcus aureus MW2

96.476

99.561

0.961
  comEA Staphylococcus aureus N315

96.476

99.561

0.961

Multiple sequence alignment