Detailed information NTG0290161

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: CSC50_RS04310
• Genome accession: NZ_CP029082
• Coordinates: 824156..825505 (+)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain AR465
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	824156..845496	824156..825505	within	0

Gene organization within MGE regions

Location: 824156..845496

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSC50_RS04310 (CSC50_0769)	ccrA	824156..825505 (+)	1350	WP_000815646.1	recombinase family protein	Machinery gene
CSC50_RS04315 (CSC50_0770)	ccrB	825527..827155 (+)	1629	WP_001186602.1	recombinase family protein	Machinery gene
CSC50_RS04320 (CSC50_0771)	-	827673..828023 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
CSC50_RS04325 (CSC50_0772)	-	828110..828421 (+)	312	WP_000700853.1	DUF960 family protein	-
CSC50_RS04330 (CSC50_0773)	-	828439..828945 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
CSC50_RS04335 (CSC50_0774)	-	828966..829283 (+)	318	WP_000659050.1	JAB domain-containing protein	-
CSC50_RS04340 (CSC50_0775)	-	829402..830487 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
CSC50_RS04345 (CSC50_0776)	-	830484..832376 (+)	1893	WP_001557544.1	site-specific integrase	-
CSC50_RS04350 (CSC50_0777)	-	832383..832760 (+)	378	WP_000361059.1	DUF6262 family protein	-
CSC50_RS04355 (CSC50_0778)	-	832911..833693 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
CSC50_RS04360 (CSC50_0779)	erm(A)	833819..834550 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
CSC50_RS04375 (CSC50_0780)	-	835059..835721 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
CSC50_RS04385	-	836066..836704 (-)	639	Protein_789	sulfite exporter TauE/SafE family protein	-
CSC50_RS04390 (CSC50_0782)	cstR	836704..836964 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
CSC50_RS04395 (CSC50_0783)	-	837100..838164 (+)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
CSC50_RS04400 (CSC50_0784)	cstB	838197..839531 (+)	1335	Protein_792	persulfide dioxygenase-sulfurtransferase CstB	-
CSC50_RS04410 (CSC50_0786)	-	839645..840754 (-)	1110	WP_000943131.1	ROK family transcriptional regulator	-
CSC50_RS04415	psm-mec	841109..841177 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
CSC50_RS04420 (CSC50_0787)	mecI	841262..841633 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
CSC50_RS04425 (CSC50_0788)	mecR1	841633..843390 (-)	1758	WP_108720631.1	beta-lactam sensor/signal transducer MecR1	-
CSC50_RS04430 (CSC50_0789)	mecA	843487..845496 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=290161 CSC50_RS04310 WP_000815646.1 824156..825505(+) (ccrA) [Staphylococcus aureus strain AR465]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=290161 CSC50_RS04310 WP_000815646.1 824156..825505(+) (ccrA) [Staphylococcus aureus strain AR465]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748