Detailed information NTG0289381

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DC427_RS10470
• Genome accession: NZ_CP029030
• Coordinates: 2026206..2027249 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CAR
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2021206..2032249

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DC427_RS10440	-	2021624..2022880 (-)	1257	WP_001795438.1	aminopeptidase	-
DC427_RS10445	-	2022883..2023083 (-)	201	WP_000180461.1	DUF1128 family protein	-
DC427_RS10450	-	2023230..2023694 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DC427_RS10455	-	2023701..2023976 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DC427_RS10460	-	2024254..2025471 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
DC427_RS10465	vraR	2025587..2026216 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
DC427_RS10470	vraS	2026206..2027249 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DC427_RS10475	liaF	2027246..2027947 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DC427_RS10480	-	2027962..2028348 (-)	387	WP_001110179.1	hypothetical protein	-
DC427_RS10485	map	2028565..2029323 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
DC427_RS10500	-	2029851..2030837 (+)	987	WP_000999713.1	FUSC family protein	-
DC427_RS10515	-	2031386..2031799 (-)	414	WP_001549145.1	hypothetical protein	-
DC427_RS10520	-	2031828..2031938 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=289381 DC427_RS10470 WP_001017131.1 2026206..2027249(-) (vraS) [Staphylococcus aureus strain CAR]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=289381 DC427_RS10470 WP_001017131.1 2026206..2027249(-) (vraS) [Staphylococcus aureus strain CAR]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1