Detailed information NTG0288048

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: DB248_RS09515
• Genome accession: NZ_CP028841
• Coordinates: 1800491..1802935 (-)
• Length: 814 a.a.
• NCBI ID: WP_010922732.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain CCUG 4207
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1795491..1807935

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DB248_RS09490 (DB248_09495)	-	1795657..1797153 (+)	1497	WP_010922730.1	C69 family dipeptidase	-
DB248_RS10385	-	1797447..1797828 (+)	382	Protein_1785	NUDIX domain-containing protein	-
DB248_RS10520 (DB248_09505)	-	1797820..1798105 (-)	286	Protein_1786	helix-turn-helix domain-containing protein	-
DB248_RS09505 (DB248_09510)	groL	1798356..1799987 (-)	1632	WP_010922731.1	chaperonin GroEL	-
DB248_RS09510 (DB248_09515)	groES	1800023..1800313 (-)	291	WP_002991292.1	co-chaperone GroES	-
DB248_RS09515 (DB248_09520)	clpC	1800491..1802935 (-)	2445	WP_010922732.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
DB248_RS09520 (DB248_09525)	-	1802935..1803396 (-)	462	WP_002982312.1	CtsR family transcriptional regulator	-
DB248_RS09525 (DB248_09530)	-	1803592..1803795 (-)	204	WP_002991299.1	cold-shock protein	-
DB248_RS09535 (DB248_09540)	ahpC	1804791..1805351 (+)	561	WP_002982304.1	alkyl hydroperoxide reductase subunit C	-
DB248_RS09540 (DB248_09545)	ahpF	1805372..1806904 (+)	1533	WP_002982300.1	alkyl hydroperoxide reductase subunit F	-

Sequence

Protein

• Length: 814 a.a.
• Molecular weight: 90714.41 Da
• Isoelectric Point: 6.8610

>NTDB_id=288048 DB248_RS09515 WP_010922732.1 1800491..1802935(-) (clpC) [Streptococcus pyogenes strain CCUG 4207]
MIMYSTKMQDIFRQAQFQAARFDSHCLETWHVLLAMVAVDNSLANMILSEYDAQVAIEEYEAAAILAMGKTPKEQLSRVD
FRPQSKTLTNLLAFAQAISQITRDQEVGSEHVLFAILLNPDIMASRLLEIAGYQIKDNGNGQPRLADLRKAIERHAGYSK
EMIKAIHELRKPKKTKTQGTFSDMMKPPSTAGELSDFTRDLTEMARQGLLESVIGRDQEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGAIPYELKEMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIEADGQIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNTEDAYQILMGLKLSYETYHNVSISN
EAVKTAVKMAHRYLTSKNLPDSAIDLLDEASAAVQNMVKKSAPETLTPIDQALINGDMKKVSRLLAKEAKGQMRKPTPVT
EDDILATLSKLSGIPLEKLTQADSKKYLNLEKELHKRVIGQDAAVTAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDEAALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTQKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGILTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVKDIHQDHQAMEKRILEELRKTYRPEFINRIDEKVVFH
SLTQDNMRDVVKIMVQPLITTLAEKGITLKIQPLALKHLSEVGYDEHMGARPLRRTLQTEIEDKLSELILSRELTSGHTL
KIGLSHGKLTFHIA

Nucleotide

• Length: 2445 bp

>NTDB_id=288048 DB248_RS09515 WP_010922732.1 1800491..1802935(-) (clpC) [Streptococcus pyogenes strain CCUG 4207]
ATGATTATGTATTCAACGAAGATGCAAGACATTTTTAGACAGGCGCAGTTCCAAGCTGCTCGCTTTGATAGCCATTGCCT
GGAAACTTGGCATGTTTTGTTAGCTATGGTAGCTGTAGATAATTCTTTAGCAAATATGATTTTAAGTGAATATGATGCCC
AAGTCGCCATAGAAGAATATGAAGCTGCAGCTATTTTAGCCATGGGCAAAACCCCTAAAGAACAGTTGTCTCGTGTAGAC
TTCAGACCTCAATCTAAAACTTTGACTAACTTGTTAGCTTTTGCGCAGGCTATTAGCCAAATCACTAGGGATCAAGAAGT
CGGCTCTGAGCATGTCTTATTTGCTATTTTATTGAATCCAGATATTATGGCGAGTCGTTTGTTAGAAATAGCTGGCTATC
AGATAAAAGATAACGGCAATGGGCAGCCGCGATTAGCTGACTTGCGAAAAGCAATAGAACGTCATGCAGGTTACAGTAAG
GAAATGATCAAGGCTATTCACGAACTACGTAAGCCTAAAAAAACGAAAACACAAGGGACCTTTTCAGATATGATGAAGCC
ACCAAGTACAGCTGGTGAGTTGAGTGATTTCACAAGAGATTTGACTGAAATGGCAAGACAAGGTTTGTTAGAATCGGTGA
TTGGACGTGACCAAGAAGTATCTCGTATGATTCAGGTACTAAGTCGTAAAACGAAAAACAATCCTGTCTTGGTAGGTGAT
GCAGGTGTTGGTAAAACTGCGCTTGCTTATGGCCTTGCTCAACGGATTGCAAATGGCGCTATTCCTTATGAACTTAAGGA
GATGCGTGTCCTAGAATTAGACATGATGAGTGTGGTAGCAGGAACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATC
AAATCATTGATGATATTGAAGCTGATGGTCAGATTATTCTTTTTGTTGATGAACTACATACTATTATGGGTTCTGGCAGT
GGTATTGACAGTACACTTGATGCGGCTAACATTTTAAAACCAGCATTATCGCGCGGCACTCTTCATATGGTTGGAGCAAC
AACTCAAGAAGAATACCAAAAACATATTGAAAAAGATGCAGCTCTTTCGCGTCGTTTTGCTAAAATATTAATTGAAGAAC
CTAATACAGAAGATGCTTATCAGATTTTGATGGGCCTAAAATTATCTTATGAGACCTACCATAATGTCTCGATATCAAAT
GAGGCAGTTAAAACAGCTGTAAAAATGGCACACCGTTATTTAACCAGTAAAAATCTCCCTGATTCAGCTATCGATTTACT
AGATGAAGCTAGTGCTGCTGTGCAAAACATGGTGAAAAAATCAGCACCTGAGACTTTAACACCAATAGACCAAGCTCTTA
TCAATGGTGATATGAAAAAAGTATCTCGCCTCTTAGCTAAAGAAGCAAAAGGTCAGATGAGAAAACCAACACCGGTGACA
GAAGATGATATTTTGGCAACCTTGAGTAAGTTATCGGGAATTCCACTTGAAAAACTGACGCAAGCTGATAGTAAAAAATA
CCTCAATTTAGAAAAAGAACTGCATAAGCGTGTGATTGGTCAGGATGCTGCTGTTACGGCTATTTCAAGAGCCATTCGTC
GTAATCAGTCAGGTATTCGAACAGGAAAACGTCCTATTGGATCATTTATGTTTCTTGGCCCAACAGGAGTAGGTAAGACA
GAACTAGCAAAGGCCCTTGCAGAAGTTCTCTTTGATGATGAAGCAGCGCTTATTCGTTTTGATATGTCTGAGTACATGGA
AAAATTCGCAGCGTCTAGGCTTAATGGAGCACCTCCTGGTTATGTCGGCTATGATGAAGGAGGTGAACTGACACAGAAAG
TTAGAAATAAACCTTATTCAGTCTTGCTTTTTGATGAAGTGGAAAAAGCACATCCTGATATTTTTAACGTTCTCCTTCAA
GTATTAGATGATGGTATATTGACTGATAGTCGTGGGCGTAAGGTCGATTTTTCAAATACTATTATTATCATGACCAGCAA
TCTTGGCGCAACAGCCCTGCGCGATGATAAAACGGTCGGTTTTGGGGTCAAAGACATTCACCAAGACCATCAAGCTATGG
AGAAACGTATTTTAGAAGAATTAAGAAAAACTTACCGCCCAGAATTTATCAATCGTATTGATGAAAAAGTGGTCTTTCAT
AGTCTGACCCAAGATAACATGCGCGATGTGGTTAAAATCATGGTACAGCCCCTGATTACTACATTGGCAGAAAAAGGTAT
TACCCTTAAAATTCAGCCTTTGGCCTTGAAACATTTGTCCGAGGTCGGCTATGATGAGCATATGGGGGCAAGACCATTAC
GTCGAACGCTGCAAACTGAGATAGAAGATAAGCTATCAGAGCTTATTCTTTCTCGAGAATTGACAAGTGGGCATACGCTA
AAAATTGGATTATCACATGGCAAATTAACGTTTCACATAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (544-715)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (722-801)

• AAA lid domain (AAA_lid_9) (376-459)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-130)

• ATPase family associated with various cellular activities (AAA) (AAA) (236-368)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	75.154	99.877	0.751
clpC	Streptococcus thermophilus LMG 18311	71.324	100	0.715
clpC	Streptococcus thermophilus LMD-9	71.201	100	0.714
clpC	Streptococcus pneumoniae TIGR4	66.093	100	0.661
clpC	Streptococcus pneumoniae Rx1	66.093	100	0.661
clpC	Streptococcus pneumoniae D39	66.093	100	0.661
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.852	100	0.493
clpC	Bacillus subtilis subsp. subtilis str. 168	42.446	100	0.435