Detailed information    

experimental Experimentally validated

Overview

Name   dprB   Type   Machinery gene
Locus tag   C694_RS01715 Genome accession   NC_018939
Coordinates   348421..348825 (+) Length   134 a.a.
NCBI ID   WP_000599146.1    Uniprot ID   -
Organism   Helicobacter pylori 26695     
Function   homologous recombination   
Homologous recombination

Function

The HP0334 (dprB) gene product facilitates high-frequency natural transformation. DprB controls in vitro growth, survival after exposure to UV or fluoroquinolones, and intragenomic recombination. dprB ruvC double deletion dramatically decreases both homologous and homeologous transformation and survival after exposure to DNA-damaging agents.


Genomic Context

Location: 343421..353825
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C694_RS01680 (C694_01660) - 343593..344531 (-) 939 WP_000833936.1 tetraacyldisaccharide 4'-kinase -
  C694_RS01685 (C694_01665) - 344528..345310 (-) 783 WP_001168317.1 NAD+ synthase -
  C694_RS01695 (C694_01670) ilvC 345559..346551 (+) 993 WP_001207734.1 ketol-acid reductoisomerase -
  C694_RS01700 (C694_01675) minD 346576..347382 (+) 807 WP_001019069.1 septum site-determining protein MinD -
  C694_RS01705 (C694_01680) minE 347379..347612 (+) 234 WP_000051415.1 cell division topological specificity factor MinE -
  C694_RS01710 (C694_01685) dprA 347624..348424 (+) 801 WP_001862983.1 DNA-processing protein DprA Machinery gene
  C694_RS01715 (C694_01690) dprB 348421..348825 (+) 405 WP_000599146.1 Holliday junction resolvase RuvX Machinery gene
  C694_RS08760 - 349111..349299 (+) 189 WP_010875464.1 hypothetical protein -
  C694_RS01725 - 349241..349657 (+) 417 WP_001862988.1 tetratricopeptide repeat protein -
  C694_RS01730 (C694_01710) - 349784..350089 (+) 306 WP_000699933.1 hypothetical protein -
  C694_RS01735 (C694_01715) - 350073..350639 (+) 567 WP_000032376.1 hypothetical protein -
  C694_RS01740 (C694_01720) - 350691..351047 (+) 357 WP_015056036.1 glycoside hydrolase family protein -
  C694_RS01745 (C694_01725) - 351035..351301 (+) 267 WP_001862993.1 hypothetical protein -
  C694_RS01755 (C694_01735) - 351607..351993 (+) 387 WP_000393582.1 DUF1294 domain-containing protein -
  C694_RS08280 - 351993..352779 (+) 787 Protein_330 hypothetical protein -
  C694_RS01770 (C694_01750) - 352769..353104 (+) 336 WP_001862999.1 hypothetical protein -

Sequence

Protein


Download         Length: 134 a.a.        Molecular weight: 15255.75 Da        Isoelectric Point: 9.1646

>NTDB_id=1213 C694_RS01715 WP_000599146.1 348421..348825(+) (dprB) [Helicobacter pylori 26695]
MILACDVGLKRIGIAALLNGVILPLEAILRHNRNQASRDLSDLLREKNIQVLVVGKPHESYADTNARIEHFIKLVDFKGE
IVFINEDRSSIEAYENLEHLGKKNKRLAIKDGRLDSLSACRILERYCQKVLKNH

Nucleotide


Download         Length: 405 bp        

>NTDB_id=1213 C694_RS01715 WP_000599146.1 348421..348825(+) (dprB) [Helicobacter pylori 26695]
GTGATTTTGGCATGCGATGTGGGGTTAAAACGCATTGGCATCGCTGCGCTTTTAAATGGCGTTATCTTGCCCTTAGAAGC
GATCTTACGCCACAACAGAAACCAGGCCTCTAGGGATTTGAGCGATTTGTTGAGGGAAAAAAACATTCAGGTGCTGGTGG
TGGGCAAGCCCCATGAAAGCTATGCGGATACGAACGCGCGCATTGAGCATTTTATCAAGCTTGTAGATTTTAAGGGCGAA
ATCGTTTTTATTAATGAAGACAGATCCAGCATAGAAGCCTATGAAAATTTAGAGCATTTGGGTAAGAAAAACAAGCGGCT
CGCTATCAAAGACGGTCGGTTAGACTCTTTGAGCGCTTGCAGGATCTTAGAGCGCTATTGCCAAAAGGTTTTGAAAAATC
ATTAG

Domains

Predicted by InterproScan.

Holliday junction resolvase (RuvX)

(2-128)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value

References

[1] Xue-Song Zhang et al. (2012) DprB facilitates inter- and intragenomic recombination in Helicobacter pylori. Journal of Bacteriology 194(15):3891-903. [PMID: 22609923]