Detailed information NTG0288036

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DB248_RS06955
• Genome accession: NZ_CP028841
• Coordinates: 1298545..1299582 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain CCUG 4207
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1293545..1304582

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DB248_RS06935 (DB248_06940)	-	1294295..1294921 (+)	627	WP_010922497.1	A24 family peptidase	-
DB248_RS06940 (DB248_06945)	rlmN	1295003..1296082 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DB248_RS06945 (DB248_06950)	-	1296086..1296706 (-)	621	WP_011285637.1	YutD family protein	-
DB248_RS06950 (DB248_06955)	-	1297154..1298131 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DB248_RS06955 (DB248_06960)	sepM	1298545..1299582 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DB248_RS06960 (DB248_06965)	coaD	1299569..1300060 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DB248_RS06965 (DB248_06970)	rsmD	1300050..1300589 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DB248_RS06970 (DB248_06975)	asnA	1300712..1301704 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
DB248_RS06975 (DB248_06980)	arcC	1302017..1302967 (-)	951	WP_010922501.1	carbamate kinase	-
DB248_RS06980 (DB248_06985)	-	1302987..1304318 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=288036 DB248_RS06955 WP_010922499.1 1298545..1299582(-) (sepM) [Streptococcus pyogenes strain CCUG 4207]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=288036 DB248_RS06955 WP_010922499.1 1298545..1299582(-) (sepM) [Streptococcus pyogenes strain CCUG 4207]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693