Detailed information NTG0287780

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: EHS18_RS12850
• Genome accession: NZ_CP034098
• Coordinates: 2530025..2532130 (+)
• Length: 701 a.a.
• NCBI ID: WP_001063330.1
• Uniprot ID: Q6GDQ0
• Organism: Staphylococcus aureus strain 80wphwpl_v1
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 2525025..2537130

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EHS18_RS12825 (EHS18_12825)	-	2525092..2525310 (+)	219	WP_000011687.1	sterile alpha motif-like domain-containing protein	-
EHS18_RS12830 (EHS18_12830)	-	2525698..2526129 (+)	432	WP_000875614.1	CHAP domain-containing protein	-
EHS18_RS12835 (EHS18_12835)	-	2526269..2527549 (-)	1281	WP_001191011.1	hydroxymethylglutaryl-CoA reductase, degradative	-
EHS18_RS12840 (EHS18_12840)	-	2527804..2528970 (+)	1167	WP_000172190.1	hydroxymethylglutaryl-CoA synthase	-
EHS18_RS12845 (EHS18_12845)	-	2529141..2529662 (-)	522	WP_000262597.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
EHS18_RS12850 (EHS18_12850)	clpE	2530025..2532130 (+)	2106	WP_001063330.1	ATP-dependent Clp protease ATP-binding subunit ClpL	Regulator
EHS18_RS12855 (EHS18_12855)	-	2532200..2532370 (-)	171	WP_000111116.1	FeoB-associated Cys-rich membrane protein	-
EHS18_RS12860 (EHS18_12860)	feoB	2532383..2534377 (-)	1995	WP_000432892.1	ferrous iron transport protein B	-
EHS18_RS12865 (EHS18_12865)	-	2534389..2534616 (-)	228	WP_000932073.1	FeoA family protein	-

Sequence

Protein

• Length: 701 a.a.
• Molecular weight: 77983.58 Da
• Isoelectric Point: 4.7492

>NTDB_id=287780 EHS18_RS12850 WP_001063330.1 2530025..2532130(+) (clpE) [Staphylococcus aureus strain 80wphwpl_v1]
MNNNFFNSDFDSILRRMMQDMQNSNQTSNKKYYINGKEVSPEELAQFTQQGGNHSAEQSAQAFQQAALRQQGQQSGNGNY
LEQIGRNLTQEARDGLLDPVIGRDKEIQETAEVLSRRTKNNPILVGEAGVGKTAIVEGLAQAIVEGNVPAAIKDKEIISI
DISSLEAGTQYRGAFEENIQKLVEGVKSSQNAVLFFDEIHQIIGSGATGSDSGSKGLSDILKPALSRGEISIIGATTQDE
YRNNIMKDAALTRRFNEVLVNEPSAKDTVEILKGIREKFETHHQVKLPDDVLKACVDLSIQYIPQRLLPDKAIDVLDITA
AHLSAQSPAIDKVTTEKRISELEHDKRKAVSAEEYKKADDIQKEIKSLQDKLENSNGEHTAVATVHDISDTIQRLTGIPV
SQMDANDIERLKNISSRLRSKIIGQDKAVEMVSRAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLAIDLFGNKEA
LIRLDMSEYSDTTAVSKMIGTTAGYVGYDDNSNTLTEKVRRNPYSVILFDEIEKANPQILTLLLQVMDDGNLTDGQGNVI
NFKNTIIICTSNAGFGNGNDTEEKDIMHEMKKFFRPEFLNRFNGIVEFLHLDKDALQDIVNLLLDDVQVTLDKKGITMDV
SQDAKDWLIEEGYDEELGARPLRRIVEQQVRDKITDYYLDHTDVKHVDIDVEDNELVVKGK

Nucleotide

• Length: 2106 bp

>NTDB_id=287780 EHS18_RS12850 WP_001063330.1 2530025..2532130(+) (clpE) [Staphylococcus aureus strain 80wphwpl_v1]
ATGAATAACAATTTTTTCAATAGTGACTTCGATTCTATTTTACGAAGAATGATGCAAGACATGCAAAACTCAAATCAGAC
TAGTAACAAGAAATACTATATTAATGGTAAAGAAGTTTCACCGGAAGAATTAGCACAATTTACGCAACAAGGTGGTAATC
ATTCTGCCGAACAAAGTGCGCAAGCTTTTCAACAAGCAGCACTAAGACAACAAGGTCAACAAAGTGGCAATGGCAATTAT
TTAGAACAAATTGGTCGTAACTTAACGCAAGAGGCTCGTGACGGATTATTAGATCCAGTCATCGGTCGTGATAAAGAAAT
CCAAGAAACTGCAGAAGTCTTAAGTAGACGCACTAAAAACAATCCTATCCTAGTCGGAGAAGCTGGAGTTGGTAAAACTG
CGATTGTCGAAGGTTTAGCGCAAGCAATCGTTGAAGGGAACGTACCTGCAGCAATCAAAGATAAAGAAATTATATCTATA
GATATTTCATCGCTTGAAGCTGGAACGCAATATCGTGGCGCCTTTGAAGAAAACATCCAAAAGTTAGTTGAAGGCGTTAA
GTCATCACAAAATGCTGTGCTCTTCTTTGACGAAATTCACCAAATCATCGGTTCCGGTGCCACAGGAAGTGATTCAGGTA
GCAAAGGGTTATCTGATATTTTAAAACCAGCATTAAGTCGTGGTGAAATTTCAATTATAGGTGCAACGACTCAAGATGAA
TATCGCAATAATATCATGAAAGACGCTGCATTAACACGTCGTTTTAACGAGGTACTGGTTAACGAACCAAGCGCAAAAGA
TACGGTTGAAATTTTAAAAGGAATTCGCGAAAAATTTGAAACACACCATCAAGTCAAATTACCTGATGACGTATTAAAGG
CATGTGTAGACTTATCCATTCAATATATTCCACAACGCCTATTACCTGACAAAGCAATCGATGTATTAGATATTACAGCT
GCACATTTATCTGCACAAAGTCCTGCTATTGATAAAGTCACGACTGAAAAACGTATTTCTGAATTGGAACATGATAAGCG
TAAAGCTGTAAGTGCTGAAGAATATAAAAAAGCAGATGACATTCAAAAAGAAATTAAATCTCTACAAGATAAATTAGAAA
ACAGTAATGGTGAACATACTGCAGTAGCAACGGTGCATGATATTTCTGATACCATTCAACGATTAACTGGTATTCCTGTA
TCTCAAATGGATGCCAATGACATTGAACGTTTAAAAAATATTTCTAGTCGTTTAAGAAGTAAAATCATCGGTCAAGATAA
AGCTGTAGAAATGGTTTCTCGTGCCATTCGTCGTAATCGAGCTGGTTTTGATGATGGTAATCGTCCAATTGGTAGCTTCC
TATTTGTCGGTCCTACTGGTGTGGGTAAAACAGAGCTTGCCAAACAGTTAGCCATTGATTTATTTGGTAATAAAGAGGCA
CTGATTCGACTTGATATGAGTGAATATAGTGATACTACTGCTGTTTCTAAAATGATTGGTACAACTGCTGGTTATGTCGG
TTATGACGATAATTCAAATACATTAACTGAAAAAGTACGACGCAATCCATATTCAGTCATTCTATTTGATGAAATTGAAA
AGGCTAATCCACAAATATTAACATTATTACTTCAAGTGATGGATGATGGTAATTTGACTGATGGTCAAGGTAATGTCATC
AACTTTAAAAATACAATTATTATTTGTACATCAAATGCTGGCTTTGGCAATGGCAATGACACTGAAGAAAAAGATATTAT
GCATGAAATGAAAAAATTCTTCCGCCCTGAATTCCTTAACCGCTTCAACGGCATCGTTGAATTCTTACATTTAGATAAAG
ATGCATTACAAGATATCGTCAACTTGTTATTAGACGATGTACAAGTTACATTAGATAAAAAAGGTATTACGATGGACGTT
TCACAAGATGCGAAAGATTGGTTAATTGAAGAAGGTTATGATGAAGAATTAGGCGCACGCCCATTAAGACGTATTGTTGA
ACAACAAGTGCGTGACAAAATAACAGATTATTATTTAGATCATACAGACGTTAAACATGTGGATATAGATGTTGAGGATA
ACGAATTAGTCGTAAAAGGTAAATAA

Domains

Predicted by InterProScan.

• AAA lid domain (AAA_lid_9) (264-363)

• AAA domain (Cdc48 subfamily) (AAA_2) (448-603)

• ATPase family associated with various cellular activities (AAA) (AAA) (123-257)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (611-682)

3D structure

• AlphaFold DB: Q6GDQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	48.607	92.154	0.448
clpE	Streptococcus pneumoniae TIGR4	47.735	88.16	0.421
clpE	Streptococcus pneumoniae R6	47.812	88.017	0.421
clpE	Streptococcus pneumoniae D39	47.812	88.017	0.421
clpE	Streptococcus pneumoniae Rx1	47.812	88.017	0.421
clpC	Lactococcus lactis subsp. cremoris KW2	46.656	89.586	0.418
clpC	Bacillus subtilis subsp. subtilis str. 168	44.122	93.438	0.412
clpC	Streptococcus thermophilus LMD-9	44.96	89.158	0.401
clpC	Streptococcus thermophilus LMG 18311	44.64	89.158	0.398
clpC	Streptococcus pneumoniae TIGR4	43.68	89.158	0.389
clpC	Streptococcus pneumoniae Rx1	43.68	89.158	0.389
clpC	Streptococcus pneumoniae D39	43.68	89.158	0.389
clpC	Streptococcus mutans UA159	43.902	87.732	0.385
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.697	88.873	0.379